Evaluation of Intra-Articular Mesenchymal Stem Cells to Augment Healing of Microfractured Chondral Defects

McIlwraith, C. Wayne; Frisbie, David D.; Rodkey, William G.; Kisiday, John D.; Werpy, Natasha M.; Kawcak, Christopher E.; Steadman, J. Richard

doi:10.1016/j.arthro.2011.06.002

Cited by 236 publications

(210 citation statements)

References 25 publications

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“…Similarly, in the other eight horses, defects treated with microfracture were paired with defects treated with microfracture followed by KLD filling, varying the placement between left and right knees. These pairings were chosen on the basis of experience with horseto-horse variation in the response to microfracture [14][15][16] .…”

Section: Methodsmentioning

confidence: 99%

Effects of the Combination of Microfracture and Self-Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model

Miller

Grodzinsky

Barrett

et al. 2014

The Journal of Bone and Joint Surgery

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Section: Methodsmentioning

confidence: 99%

Effects of the Combination of Microfracture and Self-Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model

Miller

Grodzinsky

Barrett

et al. 2014

The Journal of Bone and Joint Surgery

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“…For example, Sekiya and colleagues demonstrated that synovial stem cells inhibited the fibrillation of cartilage surface at 12 weeks postsurgery [10]. Injection of BMSCs also reduced the degree of cartilage degeneration, osteophyte formation, and subchondral sclerosis [7,[36][37][38]. MSCs may have a direct role in cartilage protection by direct remodeling of the articular cartilage surface or by acting to preserve subchondral or trabecular bone based on the relationship between early bone changes and the development of OA [39][40][41].…”

Section: Figmentioning

confidence: 99%

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Shen

Chen

Zhu

et al. 2013

Stem Cells and Development

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Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term. Here, this study aimed to identify and characterize a novel population of meniscus-derived stem cells (MeSCs) and develop a new strategy of articular cartilage protection by intra-articular injection of these cells. The ''stemness'' and immune properties of MeSCs were investigated in vitro, while the efficacy of intra-articular injection of MeSCs for meniscus regeneration and OA prevention were investigated in vivo at 4, 8, and 12 weeks postsurgery. MeSCs displayed typical stem cell characteristics such as low immunogenicity and even possessed immunosuppressive function. In a rabbit meniscus injury model, transplantation of allogenous MeSCs did not elicit immunological rejection, but promoted neo-tissue formation with better-defined shape and more matured extracellular matrix. In a rabbit experimental OA model, transplantation of MeSCs further protected joint surface cartilage and maintained joint space at 12 weeks postsurgery, whereas extensive joint surface irregularities and joint space stenosis were observed in the control group. This study thus evoked a new strategy for articular cartilage protection and meniscus regeneration by intra-articular injection of MeSCs for patients undergoing meniscectomy.

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“…In addition, use of allogenic MSC and xenoimplantation of human umbilical cord bloodderived MSC were tested in this animal model, showing induction of cartilage healing by those cell types [42,44]. Efficacy of MSC/scaffold constructs have been shown in other large animals such as sheep, horse, and goats [45][46][47][48][49]. In regards the cell delivery method, enhancement of cartilage healing after bone marrow stimulation techniques (microfracture or drilling) by postoperative intraarticular injection of MSCs was shown in horse and goat models [48,49].…”

Section: Large Animal Studiesmentioning

confidence: 99%

“…With the intent of evaluation with models that is more relevant to clinical condition in humans, large animals such as pig and sheep have been used as experimental subjects [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]. Among those, a (mini)pig model has been most frequently employed in previous studies [37][38][39][40][41][42][43][44].…”

Section: Large Animal Studiesmentioning

confidence: 99%

Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.

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Evaluation of Intra-Articular Mesenchymal Stem Cells to Augment Healing of Microfractured Chondral Defects

Cited by 236 publications

References 25 publications

Effects of the Combination of Microfracture and Self-Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model

Effects of the Combination of Microfracture and Self-Assembling Peptide Filling on the Repair of a Clinically Relevant Trochlear Defect in an Equine Model

Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells

Cartilage repair techniques in the knee: stem cell therapies

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