Evaluation of Institut Georges Lopez-1 Preservation Solution in Pig Pancreas Transplantation

García-Gil, Francisco A.; Fuentes-Broto, Lorena; Calleja, Carlos David Albendea; Serrano, M.T.; Roselló‐Catafau, Joan; Lampreave, Fermı́n; López-Pingarrón, Laura; Escartín, Jorge; Soria, Joaquín; García, Joaquín J.; Fernández‐Cruz, Laureano

doi:10.1097/tp.0000000000000050

Cited by 18 publications

(14 citation statements)

References 59 publications

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“…[27] A pilot study published by Garcia-Gil et al reports on a model of vascular pancreas allotransplantation in pigs where pancreata were transplanted after 16 hours of cold ischemia, stored in either IGL-1 (n = 8) or UW (n = 8). [8] Outcomes were: graft function (defined as normoglycemia for at least 5 days) and peak amylase / lipase levels. All grafts of the IGL-1 group functioned (8/8, 100%) whereas only six did in the UW group (6/8, 75%) as a results of vascular thrombosis.…”

Section: Plos Onementioning

confidence: 99%

“…When IGL-1 was compared to UW in a model of pig pancreas transplantation, it offered the same degree of safety and effectiveness as UW. [8] There are no reports on the long-term outcomes of pancreas transplantation after preservation with IGL-1.…”

Section: Plos Onementioning

confidence: 99%

“…[7] Hydroxyethyl starch, UW's impermeant, is associated with aggregation of red blood cells and this, in combination with its high viscosity, could lead to poor flush out of donor organs during procurement. [8][9][10] The viscosity of IGL-1 is lower than that of UW though still higher than the nonviscous HTK, so that lower volumes of IGL-1 are sufficient to ensure its efficacy as a flush-out solution during donor procedures. [8,11] PEG also has been shown to reduce influx of CD4 + and CD8+ inflammatory T-cells after perfusion.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] The viscosity of IGL-1 is lower than that of UW though still higher than the nonviscous HTK, so that lower volumes of IGL-1 are sufficient to ensure its efficacy as a flush-out solution during donor procedures. [8,11] PEG also has been shown to reduce influx of CD4 + and CD8+ inflammatory T-cells after perfusion. [12,13] PEG might even reduce ROSinduced damage as reduced lipid peroxidation was observed in isolated hepatocytes and in an isolated kidney perfusion model.…”

Section: Introductionmentioning

confidence: 99%

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IGL-1 preservation solution in kidney and pancreas transplantation: A systematic review

2020

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We aimed to systematically review published data on the effectiveness of Institut Georges Lopez-1 (IGL-1) as a preservation solution for kidney and pancreas grafts. A systematic literature search of PubMed, Embase, Web of Science, and the Cochrane Library databases was performed. Human studies evaluating the effects of IGL-1 preservation solution in kidney and/or pancreas transplantation were included. Outcome data on kidney and pancreas graft function were extracted. Of 1513 unique articles identified via the search strategy, four articles could be included in the systematic review. Of these, two retrospective studies reported on the outcome of IGL-1 compared to University of Wisconsin (UW) solution in kidney transplantation. These show kidneys preserved in IGL-1 had improved early function (2 weeks post-transplant) compared to UW. Follow-up was limited to 1 year and showed similar graft and patient survival rates when reported. Two case series described acceptable early outcomes (up to 1 month) of simultaneous kidney pancreas transplantation after storage in IGL-1. As only four clinical papers were identified, we widened our search to include four eligible large animal studies. Three compared IGL-1 with UW in pig kidney transplant models with inconclusive or mildly positive results. One pig pancreas transplant study suggested better early outcome with IGL-1 compared to UW. Too few published data are available to allow any firm conclusions to be drawn on the effectiveness of IGL-1 as a preservation solution of kidney and pancreas grafts. The limited available data show satisfactory early outcomes though no medium to long-term outcomes have been described. Further well-designed clinical studies are needed.

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Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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IGL-1 preservation solution in kidney and pancreas transplantation: A systematic review

2020

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“…The potassium concentration is low and it uses polyethylene glycol as opposed to the hydroxyethyl starch included in University of Wisconsin solution [28]. Its composition is based on University of Wisconsin solution with two key changes.…”

Section: Cold Preservation Solutionsmentioning

confidence: 99%