Evaluation of In vitro predictive tests for irritation and allergic sensitization

Molecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants

“…Clostridium perfringens and Clostridium difficile are pathogenic clostridia potentially associated with gastrointestinal infections and allergy in infants [ 8 ]. In the 1980s, studies reported the testing of sensitization and oral tolerance to ovalbumin and chemicals with Clostridium perfringens toxins [ 14 , 15 ], but the relationship between intestinal colonization by Clostridium perfringens and food allergies has not been previously reported. Prior studies have demonstrated that Clostridium perfringens colonization may cause a wide variety of pathological conditions ranging from asymptomatic infections to severe life-threatening septic shock, such as gas gangrene, food poisoning, necrotic enteritis, antibiotic-associated diarrhoea, bacteraemia, enterotoxaemia and severe intravascular haemolysis [ 16 – 21 ].…”

Molecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants

“…Clostridium perfringens and Clostridium difficile are pathogenic clostridia potentially associated with gastrointestinal infections and allergy in infants [ 8 ]. In the 1980s, studies reported the testing of sensitization and oral tolerance to ovalbumin and chemicals with Clostridium perfringens toxins [ 14 , 15 ], but the relationship between intestinal colonization by Clostridium perfringens and food allergies has not been previously reported. Prior studies have demonstrated that Clostridium perfringens colonization may cause a wide variety of pathological conditions ranging from asymptomatic infections to severe life-threatening septic shock, such as gas gangrene, food poisoning, necrotic enteritis, antibiotic-associated diarrhoea, bacteraemia, enterotoxaemia and severe intravascular haemolysis [ 16 – 21 ].…”

Methyl Green-Pyronine Staining of Porcine Organotypic Skin Explant Cultures: An Alternative Model for Screening for Skin Irritants

“…However, the pOSEC-MGP may underestimate the irritation potential of dilutions of acids and bases. Although 10% sodium hydroxide was classified as an irritant, 1% sodium hydroxide was not (Tables (41).…”

Assessment of surfactant cytotoxicity: comparison with the Draize eye test

“…Several cell culture systems have been widely used to assess cellular toxicity as predictive tests for eye irritation (17). Among them, many investigators have proposed in vitro tests to predict the irritation potential of surfactants or shampoos (18)(19)(20).…”

Molecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants

“…Clostridium perfringens and Clostridium difficile are pathogenic clostridia potentially associated with gastrointestinal infections and allergy in infants [ 8 ]. In the 1980s, studies reported the testing of sensitization and oral tolerance to ovalbumin and chemicals with Clostridium perfringens toxins [ 14 , 15 ], but the relationship between intestinal colonization by Clostridium perfringens and food allergies has not been previously reported. Prior studies have demonstrated that Clostridium perfringens colonization may cause a wide variety of pathological conditions ranging from asymptomatic infections to severe life-threatening septic shock, such as gas gangrene, food poisoning, necrotic enteritis, antibiotic-associated diarrhoea, bacteraemia, enterotoxaemia and severe intravascular haemolysis [ 16 – 21 ].…”

Methyl Green-Pyronine Staining of Porcine Organotypic Skin Explant Cultures: An Alternative Model for Screening for Skin Irritants

“…However, the pOSEC-MGP may underestimate the irritation potential of dilutions of acids and bases. Although 10% sodium hydroxide was classified as an irritant, 1% sodium hydroxide was not (Tables (41).…”

Assessment of surfactant cytotoxicity: comparison with the Draize eye test

“…Several cell culture systems have been widely used to assess cellular toxicity as predictive tests for eye irritation (17). Among them, many investigators have proposed in vitro tests to predict the irritation potential of surfactants or shampoos (18)(19)(20).…”

Molecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants

“…Clostridium perfringens and Clostridium difficile are pathogenic clostridia potentially associated with gastrointestinal infections and allergy in infants [ 8 ]. In the 1980s, studies reported the testing of sensitization and oral tolerance to ovalbumin and chemicals with Clostridium perfringens toxins [ 14 , 15 ], but the relationship between intestinal colonization by Clostridium perfringens and food allergies has not been previously reported. Prior studies have demonstrated that Clostridium perfringens colonization may cause a wide variety of pathological conditions ranging from asymptomatic infections to severe life-threatening septic shock, such as gas gangrene, food poisoning, necrotic enteritis, antibiotic-associated diarrhoea, bacteraemia, enterotoxaemia and severe intravascular haemolysis [ 16 – 21 ].…”

Methyl Green-Pyronine Staining of Porcine Organotypic Skin Explant Cultures: An Alternative Model for Screening for Skin Irritants

“…However, the pOSEC-MGP may underestimate the irritation potential of dilutions of acids and bases. Although 10% sodium hydroxide was classified as an irritant, 1% sodium hydroxide was not (Tables (41).…”

Assessment of surfactant cytotoxicity: comparison with the Draize eye test

“…Several cell culture systems have been widely used to assess cellular toxicity as predictive tests for eye irritation (17). Among them, many investigators have proposed in vitro tests to predict the irritation potential of surfactants or shampoos (18)(19)(20).…”