Evaluation of Immediate Implants Augmented with Autogenous Bone/Melatonin Composite Graft in the Esthetic Zone: A Randomized Controlled Trial

Hazzaa, Hala H.; Elkilani, Naglaa S.; Elsayed, Shadia A.; Massieh, Phoebe M. Abd El

doi:10.1111/jopr.12631

Cited by 12 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melatonin was utilized in this investigation because it has been shown to reduce the generation of free radicals in osteoclasts, a kind of bone cell. Osteoclastogenesis [ 24 ] produces a free radical, which is detoxified by the antioxidant properties of vitamin E. The overall mean marginal bone loss from baseline to nine months in group A is 1.5±0.33 and in group B is 1.37±0.56, which is in accordance with the study conducted by El-Gammal et al [ 25 ] and Hazzaa et al [ 26 ]. Our results show that there is a reduction of crestal bone loss in group B (melatonin placed implants) than in group A (implants without melatonin).…”

Section: Discussionsupporting

confidence: 87%

Evaluation of the Effect of Topical Melatonin Application on Immediately Placed Dental Implants Using Cone Beam Computed Tomography (CBCT)

Kiran¹,

Bammidi²,

Kumar³

et al. 2022

Cureus

View full text Add to dashboard Cite

Aims and objective Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a recently extracted alveolus. To compensate for this, various grafting materials are used. Recently, melatonin has gained significant attention because of its inhibitory action on bone resorption. So, we conducted the study to evaluate the effects of topical melatonin application on immediately placed implants. Methods The present study was conducted to compare the radiographic outcomes of immediately placed dental implants with and without topical application of melatonin using cone beam computed tomography (CBCT) with nine months of follow-up. A total of 14 patients were selected, of which seven were placed without the application of melatonin and seven were placed along with the application of melatonin. Within four months, all the implants were loaded functionally with permanent prostheses. Mean crestal bone levels, bone volume, and bone density are evaluated in both groups. Results There was no statistically significant difference in the amount of crestal bone loss near immediately inserted implants in the melatonin group as compared to the control group. In the bone volumetric analysis and bone density, the overall mean bone volume loss is less in the melatonin group. The statistical significance of the difference was determined. Conclusions The present study seems to support the hypothesis that the topical application of melatonin in immediately placed dental implants provides with better osseointegration and good survival rates.

show abstract

Section: Discussionsupporting

confidence: 87%

Evaluation of the Effect of Topical Melatonin Application on Immediately Placed Dental Implants Using Cone Beam Computed Tomography (CBCT)

Kiran¹,

Bammidi²,

Kumar³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…It was reported that in a one-year randomized controlled trial (RCT), melatonin improved bone mineral density, increased serum bone formation markers, and decreased the fracture risk probability compared with the control group [ 104 ]. Another RCT showed that autogenous bone/melatonin composite graft improves bone density and reduced marginal bone loss in the esthetic zone [ 105 ].…”

Section: Advances In Antiosteoporosis Drugs and Biomaterialsmentioning

confidence: 99%

Insights into the Role of Macrophage Polarization in the Pathogenesis of Osteoporosis

Wang

Liu

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Millions of people worldwide suffer from osteoporosis, which causes bone fragility and increases the risk of fractures. Osteoporosis is closely related to the inhibition of osteogenesis and the enhancement of osteoclastogenesis. In addition, chronic inflammation and macrophage polarization may contribute to osteoporosis as well. Macrophages, crucial to inflammatory responses, display different phenotypes under the control of microenvironment. There are two major phenotypes, classically activated macrophages (M1) and alternatively activated macrophages (M2). Generally, M1 macrophages mainly lead to bone resorption, while M2 macrophages result in osteogenesis. M1/M2 ratio reflects the “fluid” state of macrophage polarization, and the imbalance of M1/M2 ratio may cause disease such as osteoporosis. Additionally, antioxidant drugs, such as melatonin, are applied to change the state of macrophage polarization and to treat osteoporosis. In this review, we introduce the mechanisms of macrophage polarization-mediated bone resorption and bone formation and the contribution to the clinical strategies of osteoporosis treatment.

show abstract

“…Seet et al (2015) was considered unclear for incomplete outcome data and high risk for selective reporting. Other bias was considered the administration of other substances (Chitsazi et al, 2017; Cobo‐Vázquez et al, 2014; Seet et al, 2015; Isik et al, 2008; Ansari et al, 2018; Faghihian et al, 2018; Torun & Yüceer, 2019; Elsabagh et al, 2020; Lozano et al, 2021; El‐Gammal et al, 2016; Hazzaa et al, 2019; Lee & Curtin, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Considering the cellular effects of melatonin, this substance has been used in the medical‐dental area as an adjunctive anti‐inflammatory with the purpose of reducing the inflammation and accelerating the repair after dental procedures (Cutando et al, 2015; Hazzaa et al, 2019). Thus, the purpose of the study was to investigate different outcomes that melatonin can promote on dental conditions or dental procedures, having as a question to be answered “Does the melatonin administered systemically or topically ameliorate patients involved with oral health conditions or dental procedures?”.…”

Section: Introductionmentioning

confidence: 99%

Melatonin as an adjunctive treatment on dental procedures: A systematic review

et al. 2021

View full text Add to dashboard Cite

The systematic review tried to answer the following question: Does the melatonin administered systemically or topically ameliorate patients involved with oral health conditions or dental procedures? The systematic review has been registered in the PROSPERO (2021CRD42021095959). Eligibility criteria included only randomized controlled clinical trials (RCTs) with at least 10 participants that compared patients that received melatonin as a treatment before and/or after their oral intervention topically or systemically, with control patients. A search was performed in PubMed/MEDLINE, Web of Science, Cochrane Library, and Academic Google databases for articles up to February 2021. The Cochrane risk‐of‐bias tool for randomized clinical trials was used and revealed that the studies included presented low risk of bias for the majority of criteria assessed. It was selected 25 articles, of which only six did not demonstrate positive effects and three presented null effects with the use of melatonin. Melatonin has improved the inflammatory response in periodontal disease, dental surgeries, and mucositis of head and neck oncologic irradiated patients. In addition, it showed anxiolytic potential in patients that were submitted to dental procedures. In conclusion, melatonin favored the treatment of oral changes when used topically and systemically.

show abstract

Evaluation of Immediate Implants Augmented with Autogenous Bone/Melatonin Composite Graft in the Esthetic Zone: A Randomized Controlled Trial

Abstract: Within the limitations of this study, immediate implants augmented with ABG/melatonin composite graft would be a valuable option in the esthetic zone.

Cited by 12 publications

References 26 publications

Evaluation of the Effect of Topical Melatonin Application on Immediately Placed Dental Implants Using Cone Beam Computed Tomography (CBCT)

Evaluation of the Effect of Topical Melatonin Application on Immediately Placed Dental Implants Using Cone Beam Computed Tomography (CBCT)

Insights into the Role of Macrophage Polarization in the Pathogenesis of Osteoporosis

Melatonin as an adjunctive treatment on dental procedures: A systematic review

Contact Info

Product

Resources

About