Evaluation of genetic variants in IL‐1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population

Abstract

Background: Interleukin (IL)-1β stimulates the proliferation and differentiation of osteoclast precursors into mature osteoclasts. IL-1B polymorphisms may influence the gene and protein expression of IL-1β. The present study aimed to investigate the association of IL-1B variants (rs2853550, rs1143643, rs3136558, rs1143630, rs1143627, rs16944 and rs1143623) and their interaction with osteoporosis risk among the northwestern Chinese Han population. Methods: AN Agena MassARRAY system (Agena, San Diego, CA, USA) was employed for genotyping in 594 osteoporosis patients and 599 healthy controls. The possible association between IL-1B polymorphisms and risks of osteoporosis development was identified with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression models. Haplotype analysis and multifactor dimension reduction analysis were used to explore the potential association between combined single nucleotide polymorphisms (SNPs) and osteoporosis risk. Results: The AA genotype of rs2853550 was a protective factor for osteoporosis occurrence (OR = 0.11, p = 0.038), whereas rs16944 (OR = 1.19, p = 0.037) and rs1143623 (OR = 1.21, p = 0.025) conferred an increased risk of osteoporosis. Moreover, rs1143627, rs16944 and rs1143623 were associated with an elevated susceptibility to osteoporosis, especially in females and individuals aged > 60 years or with a body mass index > 24 kg/m 2. Haplotype G rs1143630 A rs1143627 G rs16944 was a risk factor of osteoporosis occurrence (OR = 1.20, p = 0.032). The best model of SNP-SNP analysis was a four-locus combination of rs1143643, rs3136558, rs1143630 and rs1143623 (testing accuracy = 0.5623). Conclusions: IL-1B polymorphisms and haplotype G rs1143630 A rs1143627 G rs16944 might contribute to susceptibility to osteoporosis. The SNP-SNP interaction of polymorphisms in IL-1B revealed the accumulated effect on osteoporosis risk.

Association between Interleukin-1β Gene Polymorphism and Chronic Periodontitis

“…18 Similar findings have been recorded in various pathological conditions, such as rheumatoid arthritis, where the IL-1β +3954 T allele has been linked with increased IL-1β production and associated with a higher risk for the development of such clinical manifestations. [19][20][21] In the current study, we found that the homozygous CC genotype of IL-1β +3954 was highly prevalent among the controls. However, homozygous TT and heterozygous CT genotype predominantly present in cases (►Table 2).…”

“… 18 Similar findings have been recorded in various pathological conditions, such as rheumatoid arthritis, where the IL-1β +3954 T allele has been linked with increased IL-1β production and associated with a higher risk for the development of such clinical manifestations. 19 20 21 …”

Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models

“…The top three goals for the docking scores were IL1B, RelA, and NFKB1, respectively, since a score (less than −5 kcal/mol) indicated a strong binding activity [ 42 ]. These targets have been shown to play important roles in anti-OP according to the literature [ 43 ]. In terms of IL1B, the inhibition of this target could lead to a reduction in osteoclasts and osteoblastogenesis, thereby affecting bone resorption and bone formation [ 44 ].…”

Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

“…Moreover, the SNV rs16944 G was associated with increased transcriptional activity and clinical conditions such as cardiovascular disease and gastric cancer [ 26 ]. Additionally, He and colleagues [ 30 ] investigated IL-1β genetic variants and predisposition to osteoporosis among the northwestern Chinese Han population. The authors observed an association of the IL-1 β rs16944 G allele with an elevated susceptibility to OP, especially in Chinese women >60 years (OR = 1.19, p = 0.037).…”