Evaluation of Gene Expression of TGF-B and FOXP3 in Individuals Chronically Infected with Trypanosoma Cruzi

Abstract

Chagas diseases till poses a serious endemic problem despite the fact that it was discovered over 100 years ago. The mechanisms that lead to the development of clinical manifestations may be attributed to the host immune response against the parasite. Individuals with the in Determinate (IND) form have regulatory mechanisms that limit pathology development. The aim of the present study was to assess the gene expression of TGF-β, a cytokine with an immuno regulatory profile, and FOXP3, a transcription factor, in patients with chronic Chagas disease after in vitro stimulation of Peripheral Blood Mononuclear Cells (PBMCs) with the recombinant antigens Cytoplasmatic Repetitive Antigen (CRA) and the Flagellar Repetitive Antigen (FRA) from Trypanosoma cruzi. We selected 37 patients with Chagas disease