Air pollution is simply defined as the presence of any substances such as solids, liquids and gases in the atmosphere, in the adequate amount and time that endangers the life of humans and other living creatures, or damages monuments or properties. In recent years, rapid development of industries including oil and gas industries has led to emit a considerable amount of various gaseous pollutants into the atmosphere. Therefore, developing a reliable model to predict distribution of gaseous pollutants in urban and industrial zones has become an interesting subject among environmental experts. In this study, the distribution of gaseous pollutants emitted from twenty-three stacks of different units located in Shiraz oil refining company is simulated based on the principles of Computational Fluid Dynamics (CFD). To obtain a pattern of pollutants dispersion around the Shiraz refinery, pollutants such as CO, HC, SO 2 and NO are considered. To validate the proposed model, concentration of some pollutants is measured at several points of inside and outside of the refinery area and compared with the corresponding values predicted by the proposed model. Results show that there is a good agreement between the measured data and those obtained from the CFD simulation within 6.3% accuracy. Additionally, the concentrations of SO 2 and HC in outside of refinery are sometimes more than their standard concentrations.