Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia

Ye, Zimeng; Luo, Huaichao; Gong, Bo; Lin, Ying; Shuai, Ping; Wang, Pu; Ye, Changning; Yang, Zhenglin; Wang, Wanjun; Shi, Yi

doi:10.1155/2015/729463

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…This is consistent with a previous understanding of the relationship between genes and myopia [50]. An increasing number of genes associated with high myopia have been found [51][52][53][54]. In the study of myopia among children and adolescents, the prevalence of high myopia was close to 20% in areas with a high prevalence of myopia [55,56].…”

Section: Discussionsupporting

confidence: 90%

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China：a cross-sectional study

Wang

et al. 2019

Preprint

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Background Few studies have investigated the prevalence of myopia in Northwest China. This study aimed to investigate the prevalence and risk factors of myopia and high myopia in adults aged 40-80 years in Han and Yugur ethnicities living in Gansu Province, Northwest China. Methods The cross-section study is part of the China National Health Survey (CNHS), which was conducted in 2016, Gansu Province. We compared the age- and sex-standardized prevalence of myopia, high myopia and hyperopia in Han and Yugur participants. Risk factors for myopia and high myopia were identified using multivariable logistic regression models. Results 3845 participants were included. The overall adjusted prevalence of myopia (spherical equivalent (SE)<-0.5 D), high myopia (SE<-6.0D) and hyperopia (SE>+0.5D) were 16.4%, 0.7% and 26.2% in Yugur, and 34.3%, 5.0% and 19.2% in Han. In the multivariable logistic regression model, Han ethnicity (Odds Ratio(OR),0.56; 95% confidence interval (CI): 0.45-0.69), P<0.001), birth in rural areas (OR,0.69; 95%CI: 0.56-0.85, P<0.001), higher education level (OR,1.48; 95%CI:1.18-1.85, P=0.001for middle/high school group and OR, 3.62; 95%CI:2.73-4.82, P<0.001 for Undergraduate/graduate group), indoor work (OR, 0.64; 95%CI: 0.51-0.80, P<0.001), smoking history (OR, 0.69; 95%CI: 0.52-0.90, P=0.007) and a family history of myopia (OR,2.83; 95%CI: 1.22-6.51, P=0.015 for one patient) were found to be associated with myopia. The risk factors of high myopia included Han ethnicity (OR, 0.33; 95%CI: 0.15-0.73, P=0.006), 50-59 age group (OR, 0.65; 95%CI:0.43-1.0, P=0.049), 60-69 age group (OR,0.49; 95%CI: 0.25-0.97, P=0.039), birth in rural area (OR, 0.61; 95%CI: 0.40-0.94, P=0.025) and a family history of myopia (OR, 4.32; 95%CI: 1.74-10.7, P=0.002 for one patient; OR, 22.3; 95%CI: 2.41-206.1, P=0.006 for both patients). Conclusion The prevalence of myopia and high myopia in Han adults aged 40-80 was significantly higher than that in Yugur. The risk factors of myopia included Han ethnicity, birth in rural area, higher education level, indoor work and a family history of myopia. This study provided valuable information on risk factors of myopia and revealed an ethnic disparity on the susceptibility of myopia, which would be useful in identifying high-risk population and initiating more targeted strategies preventing myopia in China.

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Section: Discussionsupporting

confidence: 90%

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China：a cross-sectional study

Wang

et al. 2019

Preprint

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“…The difference between this study and other studies is that the prevalence of high myopia in boys (3.8%) was higher than that in girls (2.7%), whereas multiple studies have shown that the prevalence of high myopia in girls is higher than that in boys [ 44 – 47 ]. A study [ 48 ] reported that the rs9307551 gene, which is related to high myopia, is highly related to the Han female population. The age range was 6 to 15 years in our study, compared with a large number of studies that reported high myopia rates in older youth (>16 years old); further investigation is needed.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Refractive Error in School Children in Suining City of Sichuan Province, China: A School-Based Cross-Sectional Study

Liu

Tang

et al. 2022

Applied Bionics and Biomechanics

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Objective. To investigate the prevalence of refractive errors among school children in Suining City, Sichuan Province, and to provide a scientific basis for prevention and control of myopia. Methods. This was a school-based cross-sectional study. Children aged 6-15 years were selected from kindergartens, primary schools, and middle schools in the urban setting of Suining City. The children underwent ocular examination including measurement of uncorrected visual acuity (UCVA), visual acuity when wearing glasses, and noncycloplegic autorefractometry. Results. Of the 1200 eligible students, 1138 children (94.8%), 553 of them girls (47.4%), participated. The mean age was 10.64 ± 2.89 years. The prevalence of myopia, hyperopia, astigmatism, and emmetropia was 59.1% (95% confidence interval (CI): 57.6, 60.5), 5.0% (95% CI: 4.7, 6.1), 38.4% (95% CI: 55.5, 58.5), and 25% (95% CI: 23.7, 26.2), respectively. In univariate analysis, the prevalence of myopia was correlated with age, female gender, and learning stage. The prevalence of hyperopia and astigmatism was correlated with age and learning stage. The prevalence of mild myopia, moderate myopia, and high myopia in the 1138 students was 17.7%, 41.4%, and 3.3%, respectively. The prevalence of mild, moderate, and high myopia all increased with age and learning stage. The prevalence of myopia differed by gender. The mean spherical equivalents of the right and left eyes were − 1.40 ± 1.99 diopters (D) and − 1.29 ± 1.93 D , respectively, and the median values were -0.75 D and -0.6 D, respectively. The mean spherical equivalent increased with age, learning stage, and female gender. Conclusions. The most common type of refractive error was myopia which was associated with higher age, female gender, and higher learning stage. This study provides new data and recommendations for myopia-control in school-aged children in Sichuan province.

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“…High myopia of genetic etiology tends to be early in onset and severe. Although an increasing number of genes associated with high myopia have been found [57][58][59][60] , previous studies have indicated that the epidemic of high myopia is caused by environmental factors 56 . "Acquired" high myopia is associated with the early onset of myopia because of the early imposition of severe study pressure, which gives myopia more time to progress before it stabilizes 56,61 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China: a cross-sectional study

Wang

et al. 2020

Sci Rep

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few studies have investigated the prevalence of myopia in northwest china. this cross-sectional study aimed to investigate the prevalence and associated factors of myopia and high myopia in adults aged 40-80 years in the Han and Yugur populations living in Gansu Province, Northwest China. A total of 3,845 participants were included. The overall age-and sex-adjusted prevalence of myopia (spherical equivalent (SE) < −0.5 D), high myopia (SE < −6.0 D) and hyperopia (SE > + 0.5 D) were 16.4%, 0.7% and 26.2% in Yugur participants, respectively, and 34.3%, 5.0% and 19.2% in Han participants, respectively. The prevalence of myopia and high myopia in Han participants was significantly higher than that in Yugur participants (both P < 0.001). Yugur population, birth in rural areas, smoking history and outdoor work were found to be negatively associated with myopia. Higher education level and a family history of myopia were found to be positively associated with myopia in the study population. High myopia was negatively associated with Yugur population, aging, birth in rural areas and was positively associated with a family history of myopia. This study provided valuable information regarding the environmental risk factors of myopia and revealed an ethnic disparity in the prevalence of myopia in Gansu province, northwest china. Refractive error, especially myopia, is a common ocular abnormality. Complications associated with high myopia have become an important cause of low vision in adolescents and adults 1,2. The prevalence of myopia differs by region. Many studies have shown that the prevalence of myopia is high in East Asia 3-6. In China, the prevalence of myopia among school-age children in urban areas is 12.7-35.8% 7,8 and 70-87.7% 8-10 in people aged over 17. Although some studies explored that the prevalence of myopia among Chinese immigrants was the highest than other ethnicities of their place of residence 11-13 , the genetic susceptibility on the high prevalence of myopia in Chinese population is not sufficient as their cultural attitudes to education sustained impact the learning pressure. Previous studies have also indicated that myopia was more related to environmental factors (early learning 14 , near work 15 , and lack of outdoor activities 16,17) than genetic factors. China is a multiethnic country composed of the Han ethnicity and 55 other populations, which results in differences in health and clinical profiles. The disparities in the prevalence of myopia in different populations in China have been studied in teenagers 18,19. The prevalence of myopia among subjects aged 4-19 years of the Han population (27%) was significantly higher than those of the Hui (18%) and Uyghur (13%) living in Turpan, China 19. One study among Han and Yi adults in Yunnan Province showed that the Yi population had a lower prevalence of myopia (8.1% vs. 10.3%; P = 0.02) 20. Disparities in myopia susceptibility may be attributed to

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Evaluation of Four Genetic Variants in Han Chinese Subjects with High Myopia

Cited by 12 publications

References 25 publications

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China：a cross-sectional study

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China：a cross-sectional study

Prevalence of Refractive Error in School Children in Suining City of Sichuan Province, China: A School-Based Cross-Sectional Study

Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China: a cross-sectional study

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