Evaluation of Flurandrenolone

Gray, Howard R.

doi:10.1001/archderm.1961.01580130024003

Arch Dermatol

1961

DOI: 10.1001/archderm.1961.01580130024003

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Evaluation of Flurandrenolone

Howard R. Gray¹

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1962

1982

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Cited by 7 publications

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“…Muscle damage including fibrosis and contracture has been reported as a complication of intramuscular drug administration (Todd 1961;Gray 1967;Hagen 1968;Norman et a1 1970;Stark 1970; Mastaglia et a1 1971; Aberfeld et all968; Steiner et a1 1973;Serrano & Wilder 1974). Psychiatric patients frequently receive antipsychotic medication by intramuscular injection.…”

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Muscle fibrosis associated with intramuscular chlorpromazine administration. A preliminary report

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et al. 1982

Journal of Pharmacy and Pharmacology

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COMMUNICATIONSdepression in rats; this did not occur with nalorphine, bremazocine and cyclazocine. Furthermore, in contrast to morphine and EK, these agents had poor efficacy in the rat tail flick test and in inhibiting gastrointestinal transit (unpublished results; Green 1959).Against this background, we have recently learned that EK does not substitute for morphine in rats receiving an i.p. infusion of morphine (Teiger 1974) (Dr M. E. Feigenson, Sterling-Winthrop, personal communication).Taken together, these data show that the in vivo pharmacological profile of EK, in rats, resembles that of morphine far more than the profiles of other proposed K compounds such as nalorphine, bremazocine and cyclazocine. The major difference between morphine and EK is the lack of substitution by EK for morphine inTeiger's rat model. In summary, we call attention to the separation between cross-tolerance and cross-dependence in the rat and pose the following question: what criteria should be used to classify opioids in this species?Generous samples of ethylketocyclazocine and nalox-one were obtained from Sterling-Winthrop and Endo, respectively.Muscle damage including fibrosis and contracture has been reported as a complication of intramuscular drug administration (Todd

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Muscle fibrosis associated with intramuscular chlorpromazine administration. A preliminary report

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Journal of Pharmacy and Pharmacology

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Total Body Inunction as Topical Corticosteroid Therapy

Goldman¹

1962

Arch Dermatol

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Percutaneous Absorption of C14-Labeled Triamcinolone Acetonide

Malkinson¹

1963

Arch Dermatol

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Evaluation of Flurandrenolone

Cited by 7 publications

References 9 publications

Muscle fibrosis associated with intramuscular chlorpromazine administration. A preliminary report

Muscle fibrosis associated with intramuscular chlorpromazine administration. A preliminary report

Total Body Inunction as Topical Corticosteroid Therapy

Percutaneous Absorption of C14-Labeled Triamcinolone Acetonide

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