Evaluation of extracorporeal shock wave therapy in Peyronie’s disease

Manikandan, Ramaswamy; Islam, Waliul; Srinivasan, V.; Evans, Christine M.

doi:10.1016/s0090-4295(02)01970-2

Cited by 45 publications

(30 citation statements)

References 18 publications

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“…[52][53][54][55] The rationale for this approach is not yet known, but has been suggested to have several possible mechanisms including (1) direct damage to the plaque resulting in an inflammatory reaction with increased macrophage activity yielding plaque lysis, (2) as a result of changes in plaque configuration and inflammatory response following ESWT, there may be improved vascularity with plaque resorption, and (3) repeated trauma to the area of plaque and deformity results in a contralateral scarring, which may shorten the contralateral side and result in a false straightening of the penis. There have been limited studies on ESWT to soft tissue.…”

Section: External Energy Therapymentioning

confidence: 99%

Review of current nonsurgical management of Peyronie's disease

Levine

2003

Int J Impot Res

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The current nonsurgical treatment options for men with Peyronie's disease is reviewed. The treatments currently employed and published in the English literature are discussed. A wide variety of nonsurgical treatment options are available to the practicing physician, including oral and topical medications, intralesional injection therapy, as well as employing external energy sources to drive medicine into the tunica albuginea by iontophoresis or direct stimulation of plaque change by shock wave therapy. Nonsurgical treatment of Peyronie's disease clearly has a place in the armamentarium of the practicing urologist. Oral therapy appears to have little therapeutic benefit. Injection and topical approaches deserve further attention. Yet, no single treatment stands out as the most effective remedy for all men with Peyronie's disease. Further controlled, large-scale studies are necessary to establish the benefits of these nonsurgical approaches. In the meantime, combination therapy appears to make sense in the nonsurgical treatment of men with Peyronie's disease.

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Section: External Energy Therapymentioning

confidence: 99%

Review of current nonsurgical management of Peyronie's disease

Levine

2003

Int J Impot Res

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“…[2][3][4][5][6][7][8][9][10][11] Many of the studies have been criticized for their lack of objectivity and relatively short follow-up periods (mean follow-up 1-9 months), and there is, therefore, a paucity of longterm data with regard to therapy effectiveness and safety. There also is a lack of information regarding the long-term durability of the response after initial success.…”

Section: Srirangam Et Al 882mentioning

confidence: 99%

“…The use of extracorporeal shockwave therapy (ESWT) for Peyronie's disease was introduced by Bellorofonte and associates 1 as a conservative option, and since then, numerous reports have addressed the efficacy of this treatment. [2][3][4][5][6][7][8][9][10][11] Reported results have been discordant, with some showing promising responses to ESWT with reductions in deformity, plaque size, and pain and concurrent improvement in sexual function, whereas others demonstrate no significant benefit. 8,10,11 In spite of reports of success and low complication rates, previous studies have been criticized for small patient numbers, absence of a control arm, use of subjective outcome measures, and lack of long-term follow-up.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Results of Extracorporeal Shockwave Therapy for Peyronie's Disease

Srirangam

Manikandan

Hussain

et al. 2006

Journal of Endourology

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Although a quarter of ESWT patients resorted to surgery, in the absence of other effective nonsurgical treatments, ESWT may provide a useful, safe, conservative management option. Extracorporeal shockwave therapy cannot yet be recommended as standard for Peyronie's disease, and randomized controlled studies are required to validate its efficacy and identify the subset of patients most likely to benefit.

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“…More recently, several uncontrolled studies have shown beneficial effects of ESWT. One study that included 42 patients treated with at least three sessions of ESWT (3000 shock waves, 0.11-0.17 mJ/mm 2 ) reported subjective improvement in 81% of the subjects [37]. A case-controlled study comparing ESWT with oral placebo showed those patients undergoing ESWT experienced a significant decrease in penile curvature [38••].…”

Section: Energy Therapymentioning

confidence: 99%

Conservative management options for peyronie’s disease

Jack¹,

González‐Cadavid²,

Rajfer

2005

Curr Urol Rep

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Peyronie's disease is an acquired condition that presents clinically with a palpable induration, a distinct plaque, or a curvature of the erect penis. At times, the erections are painful. Erectile dysfunction (ED) often is associated with Peyronie's disease. The current era of phosphodiesterase therapy for the treatment of ED seems to have increased the number of patients presenting for treatment of Peyronie's disease. During the past decade, significant advances have been made in understanding the pathophysiology of the disease, resulting in numerous nonsurgical therapies proposed for the treatment of Peyronie's disease. These medical treatments can be administered systemically, locally, or intralesionally. Unfortunately, there are few randomized, placebo-controlled trials to evaluate most of these proposed therapies. In evaluating therapies for Peyronie's disease, it must be remembered that the natural disease history includes spontaneous resolution of pain and even a small improvement in penile curvature in some men. This article reviews the natural history, scientific understanding, and nonsurgical treatment options for the mild to moderate Peyronie's deformities. Surgical therapy remains the mainstay of treatment for severe and refractory cases of Peyronie's disease that result in a physical or psychologic dysfunction.

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Evaluation of extracorporeal shock wave therapy in Peyronie’s disease

Cited by 45 publications

References 18 publications

Review of current nonsurgical management of Peyronie's disease

Review of current nonsurgical management of Peyronie's disease

Long-Term Results of Extracorporeal Shockwave Therapy for Peyronie's Disease

Conservative management options for peyronie’s disease

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