2001
Evaluation of Esterified Hyaluronic Acid as Middle Ear–Packing Material
Abstract: Objective: To evaluate the efficacy of esterified hyaluronic acid (MeroGel) as a middle ear (ME)-packing material.Design: Randomized controlled trial.Material: Twenty-four guinea pigs.Intervention: Group 1, MeroGel-treated animals (n=10), bilateral wounding of ME mucosa with 5 of the animals receiving the MeroGel packing in the left ME and 5 of the animals receiving MeroGel in the right ME; group 2, absorbable gelatin sponge-treated animals (n=10), with the same experimental protocol as in group 1 except that …
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Cited by 40 publications
(40 citation statements)
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“…In the MeroGel group, the elevated postoperative ABR threshold, as compared with the preoperative threshold, had a full recovery by postoperative week 6. This was similar to Li et al's report [11].…”
Section: Discussionsupporting
confidence: 92%
“…In the MeroGel group, the elevated postoperative ABR threshold, as compared with the preoperative threshold, had a full recovery by postoperative week 6. This was similar to Li et al's report [11].…”
Section: Discussionsupporting
confidence: 92%
“……”
Section: Discussionsupporting
confidence: 89%
“…The major concern of using AGS in otologic surgery is with retained material, fibrosis, and even complications such as osteoneogenesis. This has been well detailed in previous reports both in otologic surgery 8 and in animal models 2 – 3 , 9 – 11 . In our study, a quarter of the AGS‐packed temporal bones had an exuberant inflammatory reaction that led to osteoneogenesis.…”
Section: Discussionsupporting
confidence: 83%
