Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients

Palud, Aurore; Parmentier-Decrucq, Erika; Pastré, Jean; Caires, Nathalie De Freitas; Lassalle, Philippe; Mathieu, Daniel

doi:10.1016/j.cyto.2015.02.013

Cited by 46 publications

(35 citation statements)

References 39 publications

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“…Identical results were found in plasma samples from a cohort of septic shock patients, with a lower risk of ARDS within 72h for patients exhibiting endocan blood levels > 3.55 ng/mL at ICU admission [12].…”

Section: Accepted Manuscriptsupporting

confidence: 56%

“…In the context of severe polytrauma, endocan < 5 ng/mL at admission predicts a high risk of occurrence of ARDS within 72h [11]. A similar profile was found in severe septic patients: endocan < 3.55 ng/mL at admission allows to distinguish with high sensitivity and specificity patients developing ARDS in the first 3 days of ICU, from those who did not develop ARDS [12].…”

Section: Discussionmentioning

confidence: 52%

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Endocan is a stable circulating molecule in ICU patients

Gaudet

Chenevier‐Gobeaux²,

Parmentier

et al. 2017

Clinical Biochemistry

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Section: Accepted Manuscriptsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 52%

Endocan is a stable circulating molecule in ICU patients

Gaudet

Chenevier‐Gobeaux²,

Parmentier

et al. 2017

Clinical Biochemistry

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“…However, a previous study on CKD patients indicated that endocan maintains a good diagnostic performance, even in CKD patients [27]. Secondly, our sample size is small (pilot study), even if comparable to those of other studies on endocan [10,11,13]. We randomly selected 15 patients with an uneventful outcome for the purposes of comparison with the 5 patients with infection as we judged this to be a sufficient number for a pilot study.…”

Section: Discussionmentioning

confidence: 99%

“…Mikkelsen et al [11] evaluated endocan levels in major trauma patients at hospital admission and reported that low endocan levels were predictive of the occurrence of acute lung injury via endocan-mediated leukocyte blockage. Palud et al [10] demonstrated that in patients presenting with septic shock, low endocan levels (<3.55 ng/mL) at admission to the ICU appeared to be predictive of acute respiratory dysfunction, justifying earlier specific therapies such as a protective ventilator strategy and use of antibiotics. We also found lower basal endocan levels in patients developing postoperative pulmonary infection than in patients showing no complications (2.21 ± 1.47 vs. 3.07 ± 2.37 ng/mL), and although the difference did not reach statistical significance, the trend suggests the same biological behavior as that described above by Palud et al [10] and Mikkelsen et al [11].…”

Section: Discussionmentioning

confidence: 99%

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Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Perrotti¹,

Chenevier‐Gobeaux

Ecarnot³

et al. 2017

Cardiorenal Med

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Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD). Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Blood samples were tested at 4 time points (preoperatively and 6, 12, and 24 h after the end of surgery). Endocan, procalcitonin, and C-reactive protein plasma levels were compared between the two groups. Results: At 6 h, the patients with pulmonary infection had significantly higher levels of endocan than the patients without pulmonary infection (24.2 ± 15.6 vs. 6.4 ± 3.2 ng/mL; p = 0.03). A receiver operating characteristic curve analysis showed 80% sensitivity and 100% specificity for endocan to predict pulmonary infection (area under the curve 0.84), with a cutoff value of 15.9 ng/mL. The time saved by assessment of the endocan dosage compared to a clinical diagnosis of pulmonary infection was 47 h. Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.

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Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis

Gaudet

Portier

Mathieu

et al. 2020

Journal of Leukocyte Biology

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Dysregulated leukocyte diapedesis is a major contributor to acute severe inflammatory states like sepsis and acute respiratory distress syndrome, which are common conditions in critically ill subjects. Endocan is a circulating proteoglycan that binds to the leukocyte integrin LFA-1 and blocks its interaction with its endothelial ligand ICAM-1, subsequently leading to the inhibition of leukocyte recruitment. Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patients, as a potential antagonist of endocan, thus participating in the regulation of acute inflammation. We hereby characterize the role of p14 as a biologic competitor of endocan, through assessment of its molecular interactions with LFA-1, endocan, and ICAM-1, as well as its effects on human leukocyte trafficking. Using immunodetection assay, we report that p14 can bind to LFA-1, thus inhibiting the interaction between LFA-1 and endocan, which in turn leads to the restoration of the ICAM-1/LFA-1 interaction. In primary human T cells trafficking assays, we underline the absence of effect of p14 on ICAM-1-dependent adhesion and migration, as well as on transendothelial migration. However, in those models, p14 reverses the antimigratory effect of endocan. To conclude, our study supports the hypothesis of an antagonistic role of p14 versus endocan in its effect on the LFA-1/ICAM-1-dependent human leukocyte recruitment. K E Y W O R D Sacute lung injury, cleaved endocan, endocan, inflammation, leukocyte diapedesis, p14

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Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients

Cited by 46 publications

References 39 publications

Endocan is a stable circulating molecule in ICU patients

Endocan is a stable circulating molecule in ICU patients

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis

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