Evaluation of early and late-term infections after renal transplantation: Clinical experiences of Sanko University Medical Faculty Transplantation Center

Kazımoğlu, Hatem; Harman, Rezan; Mercimek, Mehmet Necmettin; Dokur, Mehmet; Uysal, Erdal

doi:10.5152/tud.2018.09522

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…By examining the number of complications of patients in Group Infected (not cleared before transplant) and Group Clear (cleared before transplant), it was possible to calculate the relative risk for each category of complications (fever, pneumonia, urinary tract infections, systemic infections, rejection, death) within and after 100 days of the transplantation. A study period of 100 days was chosen as the cut off between early and late complications according to what has been described in the literature [ 25 ]. No patient in either group died, but most of the patients examined had urinary tract infections (about 50% of the total had complications).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

et al. 2022

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Background Data regarding the efficacy of the dental clearance required prior to kidney transplantation (KT) for preventing post-transplant complications is controversial. The aim of this retrospective study was to investigate a possible correlation between any untreated oral infectious foci and the onset of systemic complications in KT patients. Methods Patients scheduled for regular check-ups during the post-transplant period were visited at the C.I.R. Dental School in Turin, Italy. Patients were asked to bring orthopantomography (OPT) acquired prior to transplantation to compare the possible presence of untreated infectious foci at the time of transplantation with the time of their post-transplant visit. Patients were then divided, according to the evaluation of the OPT obtained prior to the transplantation, into two groups according to their dental status prior to the transplant. “Group Infected” was comprised of patients with no dental clearance, and “Group Clear” included patients with dental clearance. The medical records were then retrospectively reviewed for the evaluation of any systemic complications that occurred after transplantation. The following medical complications were considered: fever, pneumonia, urinary tract infections, systemic infections, kidney rejection, and death. Complications were divided in two groups: early complications, which occurred within 100 days of transplantation, and late complications, which occurred more than 100 days after transplantation. Results A total of 77 patients were enrolled in the study. Group Infected was composed of 19 subjects (25%), while Group Clear was composed of 58 patients (75%). In Group Infected, 13 (68%) patients developed complications within 100 days of transplantation, and 11 (58%) did so after 100 days. In Group Clear, 31 (53%) patients had complications within 100 days of the transplant, and 23 (40%) did after 100 days. Patients in Group Infected had a statistically significant increase in episodes of fever (p = 0.03), compared to Group Clear, with a higher relative risk (RR) of 3.66 in the first 100 days after transplantation. Conclusion Within the limitations of the present retrospective pilot study, and based on the results, a correlation between the absence of dental clearance prior to KT and a higher RR of developing a fever within the first 100 days post transplantation was highlighted. The present results encourage doctors to continue research on the topic, which remains controversial. Further prospective studies are required to confirm the results of the present study.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

et al. 2022

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“…However, despite the benefits of renal transplantation, recipients encounter several problems including renal toxicity (Walsh & Dinavahi, 2016), hypertension (Severova‐Andreevska, Danilovska, Sikole, Popov, & Ivanovski, 2019), new‐onset diabetes mellitus (Nie et al, 2019), dyslipidemia and hyperuricemia following with the immunosuppressive drugs (Robledo et al, 2018). Furthermore, organ rejection can occur acutely or many years after transplantation to cause graft loss (Roth, 2017), and common complications of transplantation, such as malignancy, cardiovascular disease and infection significantly reduce the life expectancy of recipients (Kazımoğlu et al, 2019; Walsh & Dinavahi, 2016). Worry for the potential loss of the kidney and fear of rejection is the main psychological factors that influence recipients' emotional state (Costa‐Requena, Cantarell, Moreso, Parramon, & Seron, 2017a; Orr, Willis, Holmes, Britton, & Orr, 2007; dos Santos, Viegas, Rodrigues, Dall'Agnol, & Schwartz, 2018).…”

Section: Literature Reviewmentioning

confidence: 99%

Care Needs for Organ Transplant Recipients Scale: Development and psychometric testing

Chang

Lai

Tsai

et al. 2020

Journal of Renal Care

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Background Needs assessment can determine how large the gap is between needs and available services; however, no tools are available to assess the unmet needs of renal transplant recipients. Objectives The aim of this study was to develop the Care Needs for Organ Transplant Recipients Scale (CNOTRS) and examine its psychometric properties. Design A cross‐sectional design for instrument development and psychometric testing. Participants In total, 217 renal transplant recipients were recruited through convenience sampling. Methods An initial 36‐item CNOTRS was developed after a comprehensive literature review. After the CNOTRS was tested through content validity and face validity, the factor structure was explored using exploratory factor analysis (EFA). Convergent validity was examined using Pearson's correlation between the CNOTRS and Hospital Anxiety and Depression Scale (HADS). Known‐group validity was tested by comparing CNOTRS scores of patients grouped based on whether they had experienced complications or rejection. Results Twenty‐eight items with three factors (namely daily care and social interaction needs, psychological needs, and health system and service needs) were identified in EFA by parallel analysis and Velicer's MAP test. The psychological needs domain had a stronger positive correlation with the HADS than the other two domains. The known‐group validity was supported as a significant association between complications or rejection occurrence and unmet needs. The Cronbach's α of the CNOTRS was 0.94. Conclusions The CNOTRS demonstrated satisfactory reliability and validity to assess the care needs for renal transplant recipients and can assist health care professionals to tailor more personalised care for their individual needs.

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“…Early acute rejection (EAR) occurs in less than three months and late acute rejection (LAR) occurs after three months of transplant [9]. The majority of the infections are seen within 1-6 months [10] and found to be a significant problem in developing countries post-transplant [11].…”

Section: Introductionmentioning

confidence: 99%

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

Dashti¹,

Dhrolia²,

Nasir³

et al. 2022

Cureus

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The aim of our study was to evaluate the incidence, causes, risk factors, outcomes, and cost of hospital readmission after live related renal transplantation (LRRT). MethodsWe conducted a cross-sectional study and followed patients' re-admissions for six months whose LRRT was done in our center between September 2019 and June 2020. ResultsWe recruited 53 patients, 40 (75.5%) were male. The mean age was 36.9 ± 11.9 years. Donor gender was similar, and their mean age was 31.6 ± 9.2 years. The mean length of hospital stay after LRRT was 14 ± 2.2 days. A total of 81.1% were readmitted after LRRT within the first six months, with a total of 113 readmissions. The median time of readmission after LRRT was 66 days. The median readmission hospital stay was four days. The causes of readmission were surgical in 11 (9.7%), medical in 89 (78.8%), and combined medical and surgical in 13 (11.5%). Infection was the most common medical cause, followed by rejection. Statistically significant difference between readmission and non-readmission groups was found in estimated glomerular filtration rate (eGFR) at six month 61.3 ± 25.9 vs. 84.3 ± 36.1 mL/min/1.73 m 2 respectively (p = 0.02). The median cost of readmission was PKR 40629, equivalent to USD 261. ConclusionOver three-fourths of the patients were readmitted after LRRT within the first six months. The most common causes were infection and rejection. Readmissions after LRRT are associated with lower graft function at six months and a significant cost burden on the health system.

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Evaluation of early and late-term infections after renal transplantation: Clinical experiences of Sanko University Medical Faculty Transplantation Center

Cited by 6 publications

References 24 publications

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

Care Needs for Organ Transplant Recipients Scale: Development and psychometric testing

Re-Hospitalization in First Six Months After Live Related Renal Transplantation: Risk Factors, Burden, Causes and Outcomes

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