Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: Comparisons of normal skin and chronologically aged skin

Hung, Chi Feng; Fang, Chia Lang; Al‐Suwayeh, Saleh A.; Yang, Shih Yung; Fang, Jia You

doi:10.1016/j.jdermsci.2012.09.005

Cited by 52 publications

(31 citation statements)

References 54 publications

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“…The measurements of transepidermal water loss (TEWL) are useful for understanding the skin damage caused by some chemicals, pathological conditions, or environmental conditions, because the TEWL rate increases in proportion to the level of skin damage [35]. In the current study, UVB exposure of mice considerably enhanced the TEWL.…”

Section: Resultsmentioning

confidence: 74%

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

Huang

Yin

et al. 2017

IJMS

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Coffea arabica extract (CAE) containing 48.3 ± 0.4 mg/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB/c hairless mice. The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46.4%, and hydroxyl radical scavenging activity of 20.3%. The CAE dose dependently reduced UVB-induced reactive oxygen species (ROS) generation in fibroblasts. Furthermore, CAE inhibited the UVB-induced expression of cyclooxygenase-2 and p-inhibitor κB, and the translocation of nuclear factor-kappa B (NF-κB) to the nucleus of fibroblasts. In addition, CAE alleviated UVB-induced photoaging and photodamage in BALB/c hairless mice by restoring the collagen content and reduced UVB-induced epidermal hyperplasia. CAE also inhibited UVB-induced NF-κB, interleukin-6, and matrix metalloproteinase-1 expression in the hairless mouse skin. The results indicated that CAE exhibits antiphotodamage activity by inhibiting UV-induced oxidative stress and inflammation. Therefore, CAE is a candidate for use in antioxidant, antiinflammatory, and antiphotodamage products.

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Section: Resultsmentioning

confidence: 74%

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

Huang

Yin

et al. 2017

IJMS

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“…Another probability was the water loss of the SC by 1649b. SC dehydration can incur the increase of SC lipophilicity [43]. Therefore the SC partitioning of lipophilic tretinoin might be increased.…”

Section: Discussionmentioning

confidence: 99%

The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Pan

Wang

Aljuffali

et al. 2015

Journal of Dermatological Science

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128

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“…Both UVB and OVX could induce the elevation of TEWL. The loss of water results in increased SC lipophilicity (Hung et al 2012). Dextran can be classified as a hydrophilic permeant.…”

Section: Discussionmentioning

confidence: 99%

“…Viable skin offers a pronounced barrier for extremely lipophilic molecules (Hung et al 2012). We selected tretinoin (log P=6.30) as a model permeant since both the SC and the epidermis provide resistance against tretinoin diffusion .…”

Section: Introductionmentioning

confidence: 99%

Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy

Hung

Chen

Aljuffali

et al. 2015

AGE

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Ultraviolet (UV) exposure and menopause are known as the inducers of damage to the skin structure. The combination of these two factors accelerates the skin aging process. In this study, we aimed to evaluate the influence of UVand ovariectomy (OVX) on the permeation of drugs through the skin. The role of tight junctions (TJs) and adherens junctions (AJs) in the cutaneous absorption of extremely lipophilic permeants and macromolecules was explored. The OVX nude mouse underwent bilateral ovary removal. Both UVA and UVB were employed to irradiate the skin. The physiological and biochemical changes of the skin structure were examined with focus on transepidermal water loss (TEWL), skin color, immunohistochemistry, and mRNA levels of proteins. UVB and OVX increased TEWL, resulting in stratum corneum (SC) integrity disruption and dehydration. A hyperproliferative epidermis was produced by UVB. UVA caused a pale skin color tone due to keratinocyte apoptosis in the epidermis. E-cadherin and β-catenin showed a significant loss by both UVA and UVB. OVX downregulated the expression of filaggrin and involucrin. A further reduction was observed when UV and OVX were combined. The in vitro cutaneous absorption demonstrated that UV AGE (2015) increased the skin permeation of tretinoin by about twofold. However, skin accumulation and flux of estradiol were not modified by photoaging. OVX basically revealed a negligible effect on altering the permeation of small permeants. OVX increased tretinoin uptake by the appendages from 1.36 to 3.52 μg/cm 2 . A synergistic effect on tretinoin follicular uptake enhancement was observed for combined UV and OVX. However, the intervention of OVX to photoaged skin resulted in less macromolecule (dextran, molecular weight=4 kDa) accumulation in the skin reservoir because of retarded partitioning into dry skin. The in vivo percutaneous absorption of lipophilic dye examined by confocal microscopy had indicated that the SC was still important to controlling topical delivery, although the role of epidermal junctions could not be simply ignored.

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Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: Comparisons of normal skin and chronologically aged skin

Cited by 52 publications

References 54 publications

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy

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