volume 273, issue 1-2, P63-73 2004
DOI: 10.1016/j.ijpharm.2003.12.010
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Abstract: The objective of the present study was to develop a suitable method for evaluation of cytotoxicity of the oils used in Self-Emulsified Drug Delivery Systems (SEDDS) using Coenzyme Q10 (Co Q10) as a model compound. For this purpose, three methods of sample preparation were tested, namely (i) suspensions, (ii) homogenization, and (iii) nanoemulsions of oils in Dulbecco's Modified Eagle's Media (DMEM). Studies were carried out by incubating the sample or control with Caco-2 cells grown on transwell insert systems…

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