Evaluation of Co-production of Colistin Resistance and ESBL Genes among Gram-negative Clinical Isolates from Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
Tanko Nuhu,
Sulaiman A Olawale,
Mudasiru I O Raji
Abstract:Study’s Excerpt/Novelty
This study presents a comprehensive evaluation of colistin-resistant and extended-spectrum beta-lactamase (ESBL) gene co-production among Gram-negative clinical isolates from Usmanu Danfodiyo University Teaching Hospital in Sokoto.
Notably, 13.9% of the isolates exhibited phenotypic co-production of colistin resistance and ESBL, with a significant presence of blaCTX-M and CTX-M 8 genes among ESBL producers, although no colistin resistance genes (mcr-1 and mcr-2) were detected via PCR.
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