2021
DOI: 10.1001/jamanetworkopen.2020.21869
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Abstract: IMPORTANCE There exists considerable biological and clinical variability between histologic variants of metastatic renal cell carcinoma (mRCC). Data reporting on patterns of metastasis in histologic variants of mRCC are sparse.OBJECTIVE To characterize sites of metastasis and their association with survival across the 3 most common histologic variants of mRCC: clear cell (ccRCC), papillary (pRCC), and chromophobe (chrRCC). DESIGN, SETTING, AND PARTICIPANTSIn this multicenter, international cohort study, the In… Show more

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Cited by 109 publications
(74 citation statements)
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“…Brain metastases (BM) is generally associated with a very poor prognosis and high degree of morbidity, requiring urgent multidisciplinary care, and is relatively unresponsive to conventional systemic therapy [11,[16][17][18][19][20][21][22][23][24][25]. BM is also a serious condition that causes headaches, focal neurological deficits, altered mental status or gradual cognitive impairment, epileptic seizures driven by increased intracranial pressure by vasogenic edema, or alterations in cerebrospinal fluid (CSF) flow, thereby impairing the quality of life (QOL) [11,[17][18][19][25][26][27]. Unfortunately, BM is not a rare finding in mRCC (8%-15%), and its prevalence has increased in the past two decades [16][17][18][19][20][21][22].…”
Section: Clinical Implications and Unmet Needs Of Brain Metastases From Rccmentioning
confidence: 99%
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“…Brain metastases (BM) is generally associated with a very poor prognosis and high degree of morbidity, requiring urgent multidisciplinary care, and is relatively unresponsive to conventional systemic therapy [11,[16][17][18][19][20][21][22][23][24][25]. BM is also a serious condition that causes headaches, focal neurological deficits, altered mental status or gradual cognitive impairment, epileptic seizures driven by increased intracranial pressure by vasogenic edema, or alterations in cerebrospinal fluid (CSF) flow, thereby impairing the quality of life (QOL) [11,[17][18][19][25][26][27]. Unfortunately, BM is not a rare finding in mRCC (8%-15%), and its prevalence has increased in the past two decades [16][17][18][19][20][21][22].…”
Section: Clinical Implications and Unmet Needs Of Brain Metastases From Rccmentioning
confidence: 99%
“…BM is also a serious condition that causes headaches, focal neurological deficits, altered mental status or gradual cognitive impairment, epileptic seizures driven by increased intracranial pressure by vasogenic edema, or alterations in cerebrospinal fluid (CSF) flow, thereby impairing the quality of life (QOL) [11,[17][18][19][25][26][27]. Unfortunately, BM is not a rare finding in mRCC (8%-15%), and its prevalence has increased in the past two decades [16][17][18][19][20][21][22]. The median OS of RCC patients with BM (RCC-BM) is only 5-8 months [16][17][18][19][20][21][22].…”
Section: Clinical Implications and Unmet Needs Of Brain Metastases From Rccmentioning
confidence: 99%
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