Evaluation of chemical constitute, fatty acids and antioxidant activity of the fruit and seed of sea buckthorn (<i>Hippophae rhamnoides</i>L.) grown wild in Iran

Saeidi, Keramatollah; Alirezalu, Abolfazl; Akbari, Zahra

doi:10.1080/14786419.2015.1057728

Cited by 19 publications

(10 citation statements)

References 14 publications

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“…The present study, however, performed an extensive evaluation of 18 different barberry genotypes native to Iran, in order to provide valuable data and new insights useful for planning breeding strategies, as well as for selecting species with high phenolic contents for producing natural antioxidants for pharma food products. Some researchers suggest that the TPC of plants is influenced by various factors such as genetic background, longitude, sampling location, pre‐harvest and post‐harvest conditions and maturity stage at harvest …”

Section: Resultssupporting

confidence: 82%

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Gholizadeh-Moghadam

Hosseini

Alirezalu

2019

Phytochemical Analysis

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Introduction Recently, there has been a growing interest in the use of edible barberry and their extracts as a source of natural antioxidants in food and pharmaceutical industries. Objective The aim of this study was to evaluate the biochemical constituents of 18 samples of barberry fruits and classification of barberry genotypes by multivariate analysis. Methods Total phenolic, total flavonoid, total anthocyanin, total tannin, total carbohydrate contents and antioxidant activity were determined using Folin–Ciocalteu, aluminum chloride, colorimetric, vanillin, anthron and DPPH (2,2′‐diphenyl‐1‐picrylhydrazyl) assays, respectively. High‐performance liquid chromatography (HPLC) system is used for quantitative determination of phytochemical constituents. The multivariate data analysis (principal component analysis and hierarchical cluster analysis) and heat map data visualisation techniques were performed to classify barberry genotypes using Minitab and GraphPad Prism software, respectively. Results The highest amounts of total phenolics and flavonoids were obtained in fruit extracts of G3 (Berberis vulgaris). The highest total anthocyanin content and antioxidant activity were observed in G8 (B. vulgaris) and G16 (B. vulgaris), respectively. HPLC analysis of phytochemicals (gallic acid, caffeic acid, chlorogenic acid, p‐coumaric acid, cinnamic acid, rutin, apigenin, and quercetin) revealed that gallic acid and p‐coumaric acid were found as the most abundant phytochemical compounds. Based on multivariate analysis and heat map visualisation techniques, Berberis genotypes were classified into three main clusters. Conclusions These results showed that barberry species (especially B. vulgaris and B. carataegina) are promising sources of natural antioxidants and biochemical compounds beneficial to be used in the food industry and that the multivariate analysis was a suitable approach to classify the barberry samples.

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Section: Resultssupporting

confidence: 82%

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Gholizadeh-Moghadam

Hosseini

Alirezalu

2019

Phytochemical Analysis

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“…Hippophae rhamnoides L., is an edible medicinal plant used as a medicinal agent in traditional Chinese medicine and Tibetan medicine. Hippophae rhamnoides L., possesses biological properties of anti-tumor, antiinflammation, anti-oxidation, hypoglycemia and hypotriglyceridemia [21][22][23][24], whereas kaempferol and kaempferide were suggested to be active in anti-cancer, anti-inflammation, anti-oxidation, anti-diabetes, anti-obesity and neuroprotection [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells

Tie

Ding

et al. 2021

IJMS

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases which lacks ideal treatment options. Kaempferol and kaempferide, two natural flavonol compounds isolated from Hippophae rhamnoides L., were reported to exhibit a strong regulatory effect on lipid metabolism, for which the mechanism is largely unknown. In the present study, we investigated the effects of kaempferol and kaempferide on oleic acid (OA)-treated HepG2 cells, a widely used in vitro model of NAFLD. The results indicated an increased accumulation of lipid droplets and triacylglycerol (TG) by OA, which was attenuated by kaempferol and kaempferide (5, 10 and 20 μM). Western blot analysis demonstrated that kaempferol and kaempferide reduced expression of lipogenesis-related proteins, including sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD-1). Expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer binding proteins β (C/EBPβ), two adipogenic transcription factors, was also decreased by kaempferol and kaempferide treatment. In addition, western blot analysis also demonstrated that kaempferol and kaempferide reduced expression of heme oxygenase-1 (HO-1) and nuclear transcription factor-erythroid 2-related factor 2 (Nrf2). Molecular docking was performed to identify the direct molecular targets of kaempferol and kaempferide, and their binding to SCD-1, a critical regulator in lipid metabolism, was revealed. Taken together, our findings demonstrate that kaempferol and kaempferide could attenuate OA-induced lipid accumulation and oxidative stress in HepG2 cells, which might benefit the treatment of NAFLD.

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“…For instance, some studies reported that hexanol and other ma-jor derivatives found in various extracts, such as pomegranates, mung bean, ripe coffee beans and soybeans, are responsible for anti-oxidant properties (54)(55)(56). In the case of saturated fatty acids, extracts of Annona muricata L. Labisia pumila Benth, sea buckthorn, and Trifolium species also exhibited anti-oxidant activity owing to large percentages of n-hexadecanoic acid and octadecanoic acid (57)(58)(59)(60). In addition, fatty acids such as n-hexadecanoic acid and octadecanoic acid were reported to exert effects against oxidative stress (61,62).…”

Section: Resultsmentioning

confidence: 99%

GC-MS profiling, anti-oxidant and anti-diabetic assessments of extracts from microalgae Scenedesmus falcatus (KU.B1) and Chlorella sorokiniana (KU.B2)

et al. 2022

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Microalgae are a potentially valuable source in the food, pharmaceutical and nutraceutical sectors. While biological activities surveys have investigated the pharmaceutical properties of a few microalgae species, there are not many reports covering biological activity studies. This study was carried out to identify the metabolites by gas chromatography-mass spectrometry and evaluate the anti-oxidant, anti-diabetic properties of green algae extracts, Chlorella sorokiniana (KU.B2) and Scenedesmus falcatus (KU.B1). A total of 51 different chemical constituents were detected and tentatively identified. The primary compounds in both microalgae extracts included (R)-2-hexanol (38.67% in C. sorokiniana and 23.53% in S. falcatus), n-hexadecanoic acid (13.58% in C. sorokiniana and 18.94% in S. falcatus) and octadecanoic acid (22.30% in C. sorokiniana and 32.67% in S. falcatus). According to the profiling results, the C. sorokiniana extract exhibited greater anti-oxidant activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (IC50 = 480.30 ±?14.85 µg ml-1), nitric oxide (NO) radical scavenging (562.73 ±?3.52 µg mL-1) and ferric reducing anti-oxidant power (FRAP) of 58.51 ± 2.42 mgTE g-1. Comparatively, the C. sorokiniana extract had higher contents of alpha-glucosidase and alpha-amylase (IC50 = 491.22 ± 78.41 and 2,817.00 ±143.04 µg mL-1, respectively) than the S. falcatus extract. This first report demonstrated anti-diabetic effect of both extracts on diabetic enzymes. The results confirm microalgae's anti-oxidant and anti-diabetic properties and suggest their potential benefits in cosmeceutical, nutraceutical and pharmaceutical applications.

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Evaluation of chemical constitute, fatty acids and antioxidant activity of the fruit and seed of sea buckthorn (Hippophae rhamnoidesL.) grown wild in Iran

Cited by 19 publications

References 14 publications

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells

GC-MS profiling, anti-oxidant and anti-diabetic assessments of extracts from microalgae Scenedesmus falcatus (KU.B1) and Chlorella sorokiniana (KU.B2)

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