Evaluation of cardiac function and myocardial viability with 16- and 64-slice multidetector computed tomography

Kopp, Andreas F.; Heuschmid, Martin; Reimann, Anja; Kuettner, Axel; Beck, Thorsten; Ohmer, M.; Burgstahler, C; Brodoefel, Harald; Claussen, Claus D.; Schroeder, Stephen

doi:10.1007/s10406-005-0133-6

Cited by 25 publications

(12 citation statements)

References 24 publications

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“…In contrast, previous comparative studies on 16-slice and 64-slice CT systems versus MRI revealed a systematic deviation between −3.9±7.5% to 1.8± 4.7% for left-ventricular ejection fraction [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][22][23][24][25]. A recent meta-analysis on studies on MDCT left-ventricular function analysis versus MRI in 252 patients revealed a (weighted) average difference of -1.7±3.1% in left-ventricular ejection fraction [35].…”

Section: Discussioncontrasting

confidence: 63%

“…Those single-centre studies revealed a systematic overestimation of left-ventricular end-systolic volumes (ESV), most likely due to limited temporal resolution of the CT system used ranging between 125 to 250 ms [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Recently, phantom measurements as well as initial clinical experience on left-ventricular function assessment with 64-slice CT [21][22][23][24] and dual-source multidetector CT systems [26,27] have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

et al. 2008

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The purpose was to compare global left-ventricular (LV) function parameters measured with cine MRI with results from multiphase dual-source CT (DSCT) using 10 and 20 reconstruction phases. Twenty-eight patients with suspected or known CAD underwent DSCT coronary angiography. LV end-diastolic (EDV), end-systolic (ESV) and stroke volumes (SV), and ejection fraction (EF) were determined using LV segmentation and selection of specific phases from DSCT image sets reconstructed either at 5% or 10% steps through the R-R interval. Cine MRI served as the reference investigation. Threshold-based 3D-segmentation was feasible in all DSCT data sets. EDV and ESV were underestimated by DSCT, but showed excellent correlation (Pearson's correlation coefficient 0.95/0.97) to values obtained with MRI. Using data from 5% DSCT image reconstructions instead of 10% phase reconstructions, the position of the ED and ES phase was changed in 16 of 28 patients; ESVs were to found to be slightly smaller, whereas EDV were slightly larger, resulting in a systematic overestimation of LV EF by 1.9% (p=0.56). Threshold-based 3D segmentation enables accurate and reliable DSCT determination of global LV function with excellent correlation to cine MRI. Minor differences in LV EF indicate that both modalities are virtually interchangeable, even if the number of reconstructed phases is limited to 10% phase reconstructions.

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Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

et al. 2008

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“…[1][2][3][4][5][6] Using the same data for coronary CTA, two-dimensional/threedimensional (2D/3D) animation of the pulsating heart can be produced when multiple phases (e.g., 10 phases) are reconstructed. 7,8 Quantitative assessment of wall motion and systolic thickening can be evaluated and displayed with a bull's-eye map and can be pasted onto the left ventricular surface. 9 Coronary veins 10 and heart valves 11 have also become targets of multislice CT. Myocardial perfusion can also be evaluated both visually and quantitatively with Hounsfi eld units (HU), detecting hypoperfusion of the ischemic or enhanced area of the acute myocardium in a delayed scan of a contrast-enhanced study.…”

Section: Introductionmentioning

confidence: 99%

Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report

et al. 2007

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“…Previous studies have also shown only a moderate agreement between MDCT and two-dimensional imaging techniques, such as LV angiography and echocardiography (11)(12)(13), but an excellent agreement with three-dimensional methods, such as magnetic resonance imaging (1,2,4,13). Because MDCT is a true three-dimenional imaging modality with excellent spatial and contrast resolutions, it is not surprising that functional analysis with MDCT is more accurate than two-dimensional methods compared with magnetic resonance imaging, as found by Yamamuro et al (13).…”

Section: Discussionmentioning

confidence: 97%

Accuracy of the long-axis area-length method for the measurement of left ventricular volumes and ejection fraction using multidetector computed tomography

Lessick¹,

Ghersin²,

Abadi³

et al. 2008

Canadian Journal of Cardiology

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M ultidetector computed tomography (MDCT) is a versatileimaging technique, which, in a single scan, permits the evaluation of coronary anatomy, as well as ventricular function (1) as an accessory finding. A thorough evaluation, however, is rather timeconsuming, because each study involves a huge number of images at different cardiac phases, and processing the images just to calculate left ventricular (LV) ejection fraction (EF) can require up to 20 min by a dedicated technician or physician (2). A simpler method, the long-axis area-length (AL) method, which is regularly used to calculate LV volumes and EF by echocardiography, invasive LV angiography and magnetic resonance imaging (3) has, to the best of our knowledge, yet to be validated for MDCT. We aimed to compare the accuracy of LV volumes and EF calculated by the AL method with the more exact and previously validated Simpson's method (2,4) in a group of patients with a high prevalence of regional LV dysfunction. We also compared these results with right anterior oblique LV angiography, which is a routine clinical standard used for the estimation of EF. In addition, we aimed to compare single-plane with biplane results and assess interuser variability when the method is performed by users of varying experience. We hypothesized that the biplane long-axis AL method gives clinically valid results relative to the gold standard, the Simpson's method. CLINICAL STUDIES©2008 Pulsus Group Inc. All rights reserved J Lessick, E Ghersin , S Abadi, S Yalonetsky. Accuracy of the longaxis area-length method for the measurement of left ventricular volumes and ejection fraction using multidetector computed tomography. Can J Cardiol 2008;24(9):685-689.BACKGROUND: Multidetector computed tomography (MDCT) is useful for assessing left ventricular (LV) volumes and function. Validation has mainly been carried out using Simpson's method of summing up consecutive short-axis areas. Because the latter method is time-consuming, many users prefer using a quicker method, based on a single view or a pair of views. OBJECTIVES: To evaluate the accuracy of the long-axis area-length method (AL), which has not been validated for MDCT, using Simpson's method as the gold standard, as well as right anterior oblique LV angiography as a clinical standard. METHODS: Twenty-three patients admitted with acute chest pain were clinically evaluated with electrocardiogram-gated MDCT and invasive LV angiography. MDCT-based end-diastolic, end-systolic and stroke volumes, and ejection fraction (EF) were calculated using Simpson's method, biplane AL and single-plane AL. For LV angiography, EF was calculated using single-plane AL. RESULTS: A Bland-Altman analysis showed a close agreement between biplane AL and Simpson's method for EF, with 1% underestimation, 95% CI of ±11% and a correlation of 0.89. For end-diastolic, end-systolic and stroke volumes, overestimations of 7 mL, 4 mL and 2 mL, and 95% CI of ±27 mL, ±15 mL and ±26 mL, respectively were found. Correlation coefficients were 0.95, 0.97 and 0.82, respe...

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Evaluation of cardiac function and myocardial viability with 16- and 64-slice multidetector computed tomography

Cited by 25 publications

References 24 publications

Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report

Accuracy of the long-axis area-length method for the measurement of left ventricular volumes and ejection fraction using multidetector computed tomography

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