Evaluation of cancer risk in patients with periodontal diseases

Abstract

In this study, we aimed to assess the cancer risk among patients with periodontal disease. Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age-and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data. Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; 95% CI: 1.04-1.3, P = 0.006). The increased cancer risk was statistically significant in women (SIR: 1.24; 95% CI: 1.05-1.45, P = 0.008) but not in men. Among women with periodontal disease, the risks of breast cancer (SIR: 2.19) and head and neck cancer (SIR: 4.71) were significantly increased. Among men, the risks of prostate cancer (SIR: 1.84), head and neck cancer (SIR: 3.55), and hematological cancers (SIR: 1.76) were significantly increased. Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other wellknown benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure.

PD-L1 Up-Regulation in Prostate Cancer Cells by Porphyromonas gingivalis

“…Another study on 5,199 patients with 7 years of follow-up even demonstrated an increase in the risk of cancer to 17% in subjects with active periodontal diseases. Furthermore the risk of prostate cancer is significantly enhanced among men with periodontal diseases ( Guven et al., 2019 ). Increased levels of prostate specific antigen (PSA), a marker used for prostate cancer screening, were found in patients with chronic periodontal disease ( Lee et al., 2017b ).…”

Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases

“…Corbella et al (2018) reported a trend of increased cancer risk in patients with PDs but could not conclude because of the small number of studies [ 183 ]. Güven et al (2019) reported a negative association between PDs and cancers in an observational study, including 5199 patients [ 184 ]. With a follow-up of 7.2 years, patients with PDs had a 17% higher risk of cancer compared with those without PDs, for the same age groups and gender.…”

Subgingival Periopathogens Assessment and Clinical Periodontal Evaluation of Gastric Cancer Patients—A Cross Sectional Pilot Study

“…The risk of developing cancer rose to 17% in patients suffering from PD, and it was found that in patients with moderate or severe periodontitis, the risk of neoplastic tissues is higher than in patients with milder forms, although their risk is not negligible [ 41 ]. In a recent review from 2020, Nwizu et al pointed out a positive association between PD and cancer risk and hypothesized that, regarding PD, certain anatomic sites may be at higher risk for developing neoplasia, especially the esophagus and upper gastro-intestinal tract, which are adjacent to the oral cavity [ 42 ].…”