Evaluation of calcium titanate as apatite growth promoter

Coreño, J.; Coreño, Oscar

doi:10.1002/jbm.a.30447

Cited by 64 publications

(49 citation statements)

References 31 publications

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“…The resolution capability of our XPS apparatus was relatively low so that we could not obtain similar results; in our case, however, some Ca on the surface of titanium may also be present as calcium titanate. In addition, the surface of calcium titanate reportedly releases some Ca ions [22]. In this context, the state of surface Ca on the surface of titanium hydrothermally treated with CaCl 2 could be presumed to comprise both ion and stable compounds.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it was reported that calcium titanate releases Ca ions, thereby forming a surface richer in TiO 2 , which would in turn transform TiOH groups. Both surface Ca and TiOH sites then adsorb phosphate ions, which may cause apatite nucleation on its surface [22]. In this context, the surface Ca layer may contribute to protein/ cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

et al. 2012

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In the present study, we investigated the hydrothermal treatment of titanium with divalent cation solutions and its effect in promoting the adhesion of gingival epithelial cells and fibroblasts in vitro. Gingival keratinocyte-like Sa3 cells or fibroblastic NIH3T3 cells were cultured for 1 h on experimental titanium plates hydrothermally-treated with CaCl2 (Ca) or MgCl2 (Mg) solution, or distilled water (DW). The number and adhesive strengths of attached cells on the substrata were then analyzed. The number of Sa3 cells adhering to the Ca- and Mg-treated plates was significantly larger than in the DW group, but the strength of this adhesion did not differ significantly between groups. In contrast, NIH3T3 cell adhesion number and strength were increased in both the Ca and Mg groups compared to the DW group. Fluorescent microscopic observation indicated that, in all groups, Sa3 had identical expression levels of integrin β4 and development of actin filaments, whereas NIH3T3 cells in the Ca and Mg groups displayed much stronger punctate cytoplasmic signals for vinculin and more bundle-shaped actin filaments than cells in the DW group. As a result, it was indicated that the hydrothermal treatment of titanium with Ca or Mg solution improved the integration of soft tissue cells with the substrata, which may facilitate the development of a soft tissue barrier around the implant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

et al. 2012

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“…These powders were mixed homogeneously, shaped and sintered into disc of diameter 5-6 mm and thickness of 1-2 mm. Details of sample preparation are given in our earlier reports [9]. Dielectric and pyroelectric measurements were conducted on these samples.…”

Section: Methodsmentioning

confidence: 99%

“…BaTi03 and CaTi03, belonging to the same perovskite family and being bio-friendly materials, have been tried for the synthesis of HAp:BTO and HAp:CTO composites. The CTO has proven to be a good substrate for the apatite growth since it provides a positive surface charge that interacts with the negatively charged phosphate ions in the fluid [9]. This paper focuses on the measurements of dielectric and pyroelectric current generation characteristics of the synthesized composites as a function of temperature.…”

Section: Introductionmentioning

confidence: 99%

Electrical Properties of Calcium Titanate: Hydroxyapatite Composites

Pal

Dubey

Basu

et al. 2012

Ceramic Transactions Series

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Perovskite BaTi03:hydroxyapatite (HAp) composites have shown promises for possible applications in synthetic bone materials. This paper reports the synthesis and electrical properties of composites of the perovskite family calcium titanate, a well known ferroelastic material that shows quantum paraelectric-like dielectric behavior at temperatures below 50K, with hydroxyapatite. The dielectric and pyroelectric properties of these composites have been studied. The results show that CaTi03 retains its characteristic behavior in the composite with HAp and thus its quantum paraelectric-like behavior is sustained. Results are discussed in view of the standard Barrett equation for the quantum paraelectric or incipient ferroelectric behavior. INTRODUCTIONComposites of ferroelectric BaTi03 and Hydroxyapatite [Caio(P0 4 ) 6 (OH)2] have recently been studied for their potential applications as bone analog material [1]. As an extension of this work, composites of calcium titanate (CTO) and hydroxyapatite have been synthesized and studied for their suitability as a potential material for orthopedic implant applications. The preliminary data on these composites is very promising; the advantages of CTO-HAp composite over HAp have been discussed in details [2]. In this work, we have measured and evaluated the dielectric and pyroelectric properties of these composites. At room temperature, CTO has orthorhombic structure with lattice parameters a = 5.367 A, b = 7.644Ä and c = 5.444Ä. The dielectric constant as a function of temperature behaves more like a quantum paraelectric or incipient ferroelectric materials like SrTi03 and KTa03. In a typical quantum paraelectric (QPE) case, the dielectric constant does not vary with temperature below certain temperature. These temperatures as reported in the literature are ~ 30K for SrTi03 and ~5K for KTa0 3 [3][4]. In this regime, the ferroelectric fluctuations (and polarization) in the paraelectric phase are overtaken by the quantum fluctuations. The dielectric properties of a quantum paraelectric phase C can be well described by the Barrett equation, ε -A + -jry ψ-ρ , where A is the (%)coth(% r )-r 0

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“…TiO 2 -based bioactive ceramic suggests that bone grafting is achieved by supporting the precipitation of calcium (Ca) and phosphorus (P) into a structure similar to the mineral phase of bone. Accordingly, titanium is very promising to develop biomedical materials and devices designed as hard tissue substitutes with improved interface properties (Coreno & Coreno, et al 2005;Hench, 1991;Li, et al, 1996;Kitsugi et al, 1996).…”

Section: Applicationsmentioning

confidence: 99%