Evaluation of caffeine versus codeine for pain and swelling management after implant surgeries: A triple blind clinical trial

Samieirad, Sahand; Afrasiabi, Hadi; Tohidi, Elahe; Qolizade, Mohsen; Shaban, Baratollah; Hashemipour, Maryam Alsadat; Shirvan, Isa Doaltian

doi:10.1016/j.jcms.2017.06.014

Cited by 21 publications

(24 citation statements)

References 42 publications

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“…Several studies have been conducted in PA in dentistry. Most studies focus on third molar extraction surgeries (7-10,12,28) followed by periodontal surgeries (13)(14)(15) and studies on implantology (1,(16)(17)(18). Moreover, in almost all different procedures using PA, the results are conflicting.…”

Section: Discussionmentioning

confidence: 99%

“…Three classes of analgesic drugs [blockages with local anesthetics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids] have been used for this purpose alone or in combination (5,6). Several studies have been conducted in PA, particularly in third molar extraction surgeries (7-12,) periodontal surgeries (13)(14)(15), and few studies in implant dentistry (1,(16)(17)(18), with conflicting results. In addition, different types of drugs have been tested in PA (1,9,(13)(14)(15)(16) however without a consensual definition of the best protocol regarding the drug, posology and period of exposure to the drug.…”

Section: Introductionmentioning

confidence: 99%

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Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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Background: Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods: For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. Results: The IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p< 0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

View full text Add to dashboard Cite

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“…Up to now, the commonly prescribed anti-inflammatory agents mainly include steroidal anti-inflammatory drugs (SAIDs), non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase inhibitors [ 17 – 19 ]. Despite suppressing inflammatory features and so improving the quality of life for arthritis patients, steroids and cyclooxygenase inhibitors are symptom-suppressing drugs by easing pain and diminishing swelling in treating arthritis [ 20 , 21 ]. What's worse, NSAIDs may lead to serious side effects including peptic ulceration [ 22 , 23 ], gastrointestinal damage [ 24 ] and ulcer complications [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects and Mechanisms of Rhein, an Anthraquinone Compound, and Its Applications in Treating Arthritis: A Review

Wang

Yang

et al. 2020

Nat. Prod. Bioprospect.

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Inflammation is a defensive response of living tissues to damaging agents, which exists in two forms, acute inflammation and chronic inflammation, and chronic inflammation is closely related to arthritis. Currently, the commonly prescribed anti-inflammatory medications are greatly limited by high incidence of gastrointestinal erosions in the clinical applications. Rhein, a bioactive constituent of anthraquinone, exhibits excellent anti-inflammatory activities and therapeutic effects on arthritis with less gastrointestinal damages. Although there are numbers of studies on anti-inflammatory effects and mechanisms of rhein in the last few decades, to the best of our knowledge, only a few review articles pay attention to the interactive relationships of rhein on multiple inflammatory signaling pathways and cellular processes from a comprehensive perspective. Herein, we summarized anti-inflammatory effects and mechanisms of rhein and its practical applications in the treatment of arthritis, thereby providing a reference for its basic researches and clinical applications.

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“…On a similar note, in vitro studies showed the presence of coffee extracts on lipopolysaccharide (LPS)-treated murine macrophage-like cells showed a decrease in mRNA levels of TNF-α and IL-6 (Jung et al 2017). Such an anti-inflammatory effect of caffeine correlates with reduced expression of IL-6, IL-3, and IL-12 by LPS-treated murine macrophage cells (Samieirad et al 2017). In another study, 50μM caffeine treatment on LPS-activated cord blood (neonatal) monocytes showed a 20% decrease of TNF-α production (Chavez-Valdez et al 2009) and at a concentration of 100μM caffeine suppressed the TNF-α production by LPS-stimulated human whole blood by approximately 40% (Horrigan et al 2004).…”

Section: Caffeinementioning

confidence: 81%

Potential role of methylxanthines as an adjuvant to COVID-19 treatment: A review of Pentoxifylline and caffeine as the case of any port in the storm

Monji

Siddiquee

Hashemian

2020

Preprint

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COVID-19 pandemic presents an unprecedented challenge to identify effective drugs for treatment. Despite multiple clinical trials using different agents, there is still a lack of specific treatment for COVID-19. Having the possible role in suppressing inflammation, immune modulation, antiviral and improving respiratory symptoms, this review discusses the potential role of methylxanthine drugs like pentoxifylline and caffeine in the management of COVID-19 patients. COVID-19 pathogenesis for clinical features like severe pneumonia, acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), and multi-organ failures are excessive inflammation, oxidation, and cytokine storm by the exaggerated immune response. Drugs like pentoxifylline have already shown improvement of the symptoms of ARDS and caffeine has been in clinical use for decades to treat apnea of prematurity (AOP) in preterm infants and improve respiratory function. Both pentoxifylline and caffeine are well-known anti-inflammatory and anti-oxidative molecules that have already shown to suppress Tumor Necrosis Factor (TNF-α) as well as other inflammatory cytokines in pulmonary diseases, and this may be beneficial for better clinical outcomes in COVID-19 patients. Pentoxifylline enhances blood flow, improves microcirculation and tissue oxygenation, and caffeine also efficiently improves microcirculation, reduces cardiovascular disease, and an effective analgesic. There are significant shreds of evidence that proved the properties of pentoxifylline and caffeine against virus-related diseases as well. Along with the aforementioned evidences and high safety profiles, both pentoxifylline and caffeine offer a glimpse of considerations for future use as a potential adjuvant to COVID-19 treatment. However, additional clinical studies are required to confirm this speculation.

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Evaluation of caffeine versus codeine for pain and swelling management after implant surgeries: A triple blind clinical trial

Cited by 21 publications

References 42 publications

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Anti-inflammatory Effects and Mechanisms of Rhein, an Anthraquinone Compound, and Its Applications in Treating Arthritis: A Review

Potential role of methylxanthines as an adjuvant to COVID-19 treatment: A review of Pentoxifylline and caffeine as the case of any port in the storm

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