Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats

Ishii, Yoshiharu; Maki, Mimi; Yamamoto, Hiromi; Sasase, Tomohiko; Kakutani, Makoto; Ohta, Takeshi

doi:10.1538/expanim.59.525

Cited by 14 publications

(15 citation statements)

References 21 publications

(30 reference statements)

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“…Hypertension is known to contribute to the development of diabetic complications, and thus a reduction in blood pressure helps to prevent them [38]. SDT fatty rats also develop hypertension in the first few weeks of age [39], which might accelerate the deterioration of diabetic complications of retinopathy, neuropathy, and nephropathy. Recently, treatment with SGLT2 inhibitors has shown promise in reducing blood pressure [40].…”

Section: Discussionmentioning

confidence: 99%

Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Takakura

Toyoshi²,

Hayashizaki

et al. 2016

Life Sciences

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Section: Discussionmentioning

confidence: 99%

Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Takakura

Toyoshi²,

Hayashizaki

et al. 2016

Life Sciences

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“…The expansion of nodular lesions to mesangial matrix is characteristic in OLETF rats and SDT fatty rats. The reason SDT fatty rats showed a significant nodular lesion might be related with an elevation of blood pressure, one of the characteristics in SDT fatty rats [28, 29]. The tubulointerstitial scaring and inflammation were observed in ZDF rats and SDT fatty rats.…”

Section: Renal Lesionsmentioning

confidence: 99%

Diabetic Complications in Obese Type 2 Diabetic Rat Models

et al. 2014

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We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

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“…An ACE inhibitor also improved autonomic imbalances in diabetic hypertensive db/db mice [3]. Because SDT fatty rat shows both marked dyslipidemia (Table 1) and hypertension [6], these two factors may be deeply involved in the DPN of this animal model. Clarifying the participation of these factors in neuropathies will provide critical information for the development of new drugs for DPN.…”

mentioning

confidence: 82%

Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats

Yamaguchi

Sasase

Mera

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes. KEY WORDS: diabetes, diabetic peripheral neuropathy, nerve conduction velocity, SDT fatty rat.doi: 10.1292/jvms.12-0149; J. Vet. Med. Sci. 74(12): 1669-1673, 2012 Diabetes mellitus (DM) is a major metabolic disease, and the number of diabetics worldwide is estimated at approximately 350 million [5]. More than half of all DM patients have one or more diabetic microvascular complications such as diabetic retinopathy, diabetic nephropathy, or diabetic peripheral neuropathy (DPN). DPN is the most frequent complication, and nearly half of all diabetics suffer some type of nerve damages or symptoms [1]. Moreover, DPN causes foot ulceration, amputation, and chronic pain that reduce quality of life. Large clinical trials have proven that strict control of blood glucose level can delay the onset and progression of diabetic complications, including DPN [16,26].To clarify the pathophysiology of DPN, many diabetic animal models have been reported [2,14,30]. Spontaneously Diabetic Torii (SDT) rat is a model for non-obese type 2 diabetes [24,25] showing pronounced hypoinsulinemia and hyperglycemia due to pancreatic β-cell degeneration from around 20 weeks of age [11]. SDT rat shows all three major diabetic complications in kidneys [17], nerves [21,27], and especially in eyes [19,22,24,25]. Although the SDT rat is a useful model to study diabetic complications, a late onset of hyperglycemia brings disadvantage for laboratory experiments not infrequently. To solve this problem, the SDT fatty rat was established by introducing the fa allele of the Zucker fatty rat into the SDT rat genome [10]. This animal model develops diabetes from 5-6 weeks of age, and the time for progression is much earlier than that of original SDT rat (13-24 weeks, Table 1). The SDT fatty rats showed hyperinsulinemia at early stage of diabetes (4-8 weeks), but the insulin levels decreased to normal levels after 16 weeks of age. Plasma triglyceride (TG) and total cholesterol (TC) levels in SDT fatty rats were significantly higher than those in original SDT rats. These properties mitigate evaluation of diabetic complications. Although the eye and kidney complications in this animal model have been reported previously [12], nerve complications have not been examined. Therefore, in the present study, we evaluated the DPN in SDT fatty...

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Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats

Cited by 14 publications

References 21 publications

Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Diabetic Complications in Obese Type 2 Diabetic Rat Models

Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-<i>Lepr</i><sup><i>fa</i></sup> (SDT Fatty) Rats

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