Evaluation of Bisphenol A influence on endocannabinoid system in pregnant women

Zbucka-Krętowska, Monika; Zbucki, Robert; Parfieniuk, Ewa; Masłyk, Maciej; Lazarek, Urszula; Miltyk, Wojciech; Czerniecki, Jan; Wołczyński, S; Krętowski, Adam; Ciborowski, Michał

doi:10.1016/j.chemosphere.2018.03.195

Cited by 25 publications

(15 citation statements)

References 35 publications

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“…The adverse health effects of exposure to BPA are far reaching as it has been linked to various hormonal, metabolic, reproductive, and developmental defects. BPA has been implicated in several reproductive disorders including infertility [36,37], reduced sperm count and motility [38], and increased risk for miscarriages and genital birth defects [32,39], as well as other health issues such as asthma and Autism spectrum disorder [20,[40][41][42]. Even low-dose exposure to BPA has been associated with increased rates of breast and prostate cancer [43][44][45], brain and behavioral abnormalities, metabolic disorders, and obesity [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity

Cohen

Cohenour

Harnett

et al. 2021

IJMS

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Bisphenol A (BPA) is an endocrine-disrupting chemical used in the production of plastics, and is linked to developmental, reproductive, and metabolic disorders including obesity. Manufacturers have begun using ‘BPA-free’ alternatives instead of BPA in many consumer products. However, these alternatives have had much less testing and oversight, yet they are already being mass-produced and used across industries from plastics to food-contact coatings. Here, we used human female adipose-derived stem cells (hASCs), a type of adult mesenchymal stem cell, to compare the effects of BPA and BPA alternatives on adipogenesis or fat cell development in vitro. We focused on two commonly used BPA replacements, bisphenol AF (BPAF) and tetramethyl bisphenol F (TMBPF; monomer of the new valPure V70 food-contact coating). Human ASCs were differentiated into adipocytes using chemically defined media in the presence of control differentiation media with and without 17β-estradiol (E2; 10 μM), or with increasing doses of BPA (0, 0.1 and 1 μM), BPAF (0, 0.1, 1 and 10 nM), or TMBPF (0, 0.01 and 0.1 μM). After differentiation, the cells were stained and imaged to visualize and quantify the accumulation of lipid vacuoles and number of developing fat cells. Treated cells were also examined for cell viability and apoptosis (programmed cell death) using the respective cellular assays. Similar to E2, BPA at 0.1 μM and BPAF at 0.1 nM, significantly increased adipogenesis and lipid production by 20% compared to control differentiated cells (based on total lipid vacuole number to cell number ratios), whereas higher levels of BPA and BPAF significantly decreased adipogenesis (P < 0.005). All tested doses of TMBPF significantly reduced adipogenesis and lipid production by 30–40%, likely at least partially through toxic effects on stem cells, as viable cell numbers decreased and apoptosis levels increased throughout differentiation. These findings indicate that low, environmentally-relevant doses of BPA, BPAF, and TMBPF have significant effects on fat cell development and lipid accumulation, with TMBPF having non-estrogenic, anti-adipogenic effects. These and other recent results may provide a potential cellular mechanism between exposure to bisphenols and human obesity, and underscore the likely impact of these chemicals on fat development in vivo.

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Section: Introductionmentioning

confidence: 99%

BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity

Cohen

Cohenour

Harnett

et al. 2021

IJMS

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“…Positive correlations were observed between fatty acid amides and free and total BPA concentrations whereas OEA was positively correlated with conjugated BPA and lysophosphatidylethanolamine (LPE) with free BPA. Interestingly, in vitro study revealed that BPA caused a 15% inhibition of FAAH activity, therefore resulting in a competitive inhibitor capable of blocking FAAH catalytic residues [181]. Since FAAH activity is critical for regulating both the magnitude and duration of AEA signaling, this study has particular relevance in that BPA exposure may lead to a rise in circulating endocannabinoids, a well-known risk factor for miscarriage.…”

Section: Es and Ecs Modulation By Estrogens-like Substances Affecting Cns And Gonadsmentioning

confidence: 88%

“…Recently the effects of BPA on ECS have been evaluated in pregnant women, providing evidence of BPA interference in ECS signaling and hypothesizing that BPA may induce adverse pregnancy outcomes modulating the activity of the ECS [181]. In this study liquid chromatography-mass spectrometry (LC-MS)-based plasma metabolomics was performed in pregnant women with known concentrations of free, conjugated, and total BPA.…”

Section: Es and Ecs Modulation By Estrogens-like Substances Affecting Cns And Gonadsmentioning

confidence: 99%

The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery

Mele

Marino

Viggiano

et al. 2021

IJMS

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The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hormones, regulate growth, differentiation, and many other functions in a broad range of target tissues and both sexes through the activation of nuclear and membrane estrogen receptors (ERs), which leads to genomic and non-genomic cell responses. Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer.

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“…Indeed, numerous association studies have linked BPA and analogs to human reproductive diseases and disorders including increased miscarriage rates ( Sugiura-Ogasawara et al, 2005 , Zbucka-Kretowska et al, 2018 ), low fetal birth weight ( Huo et al, 2015 ), birth defects such as male hypospadias ( Pallotti et al, 2020 ), endometriosis ( Buck Louis et al, 2013 , Simonelli et al, 2017 ), polycystic ovary syndrome ( Rutkowska and Rachon, 2014 ), breast and prostate cancer ( Jenkins et al, 2009 , Moral et al, 2008 , Shafei et al, 2018 , Zhang et al, 2014 ), and precocious puberty ( Leonardi et al, 2017 ), in addition to many neurological, immune, and metabolic disorders ( Robinson and Miller, 2015 , Kardas et al, 2016 , Thongkorn et al, 2019 , Li et al, 2018 , Tewar et al, 2016 , Legeay and Faure, 2017 , Wang et al, 2012 , Wang et al, 2019 , Yang et al, 2020 , Youssef et al, 2018 ). Further, several large studies have reported that in couples undergoing in vitro fertilization (IVF) there were significant correlations between higher urinary BPA concentrations and reduced sperm counts, and abnormal sperm motility and morphology in men, reduced oocyte yield and peak serum estradiol in women, and reduced success with IVF ( Joint and WHO, 2011 , Matuszczak et al, 2019 , Mok-Lin et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

Harnett

Moore

Chin

et al. 2021

Current Research in Toxicology

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Evaluation of Bisphenol A influence on endocannabinoid system in pregnant women

Cited by 25 publications

References 35 publications

BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity

BPA, BPAF and TMBPF Alter Adipogenesis and Fat Accumulation in Human Mesenchymal Stem Cells, with Implications for Obesity

The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery

Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

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