Evaluation of biochemical and production parameters of broiler chicks fed ammonia treated aflatoxin contaminated maize grains

Allameh, Abdolamir; Safamehr, A R; Mirhadi, S A; Shivazad, M; Razzaghi-Abyaneh, Mehdi; Afsharnaderi, Azam

doi:10.1016/j.anifeedsci.2005.03.005

Cited by 68 publications

(46 citation statements)

References 21 publications

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“…Use of ALT as predictive marker of AFB1 liver toxicity can find support in the recent work of Yang et al (14) in which the elevated level of serum ALT was one of the cascade three steps model of liver injury induced by total saponins of plant origin. On the other hand, the non-significant elevation of AST in response to AFB1 toxicity, reported in the present study, is not in good agreement with the previous study of Allameh et al (15) which showed that serum lactate dehydrogenase (LDH) and AST demonstrate more dependency on the exposure duration and concentration of aflatoxins. Tables 2 together with figures 2 and 3 demonstrate Pearson's correlations between ALT, AST, age and AFB1 as the four measured variables in this study It can be easily noticed that AFB1was positively correlated (P˂0.001) with AST and ALT.…”

Section: Discussioncontrasting

confidence: 53%

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Farag

Alayobi²,

Alsaleh

et al. 2016

Preprint

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Abstract:Background: Exposure to chronic low levels of aflatoxin B1 (AFB1) contamination can lead to immune suppression and nutritional consequences that might greatly contributed in the increase of hepatocellular carcinoma (HCC). The toxicity of AFB1 is greatly vary between different population, affected by age, gender, and environmental factors. Material and subjects: Aflatoxin B1 (AFB1) was measured in 50 blood samples collected from non B, C hepatitis viruses and non CMV-Ab liver disease patients from different general hospitals and polyclinic in KSA during period 01-2013 to 06-2014. All Patients demonstrate elevation of ALT and AST with unknown etiology. Serum samples were obtained and kept at −20 °C for AFB1detection. Results: Out of the 50 blood samples, 38 demonstrate a detectable serum level of AFB1 while the remaining 12 patients were AFB1 negative and used as control participants. While AST was non-significantly different in AFB1 exposed patients, ALT was significantly higher in AFB1 positive samples compared to control AFB1-negative. AFB1 was positively correlated with AST and ALT as liver function enzymes and with age as a risk factor of long duration of AFB1 chronic exposure. Multiple linear regression analysis ascertained the association between AFB1 chronic exposure and ALT increase in liver dysfunction Saudi patients. Conclusion: Measurement of elevated ALT as marker of liver injury in AFB1 chronically exposed Saudi patients can help to avoid the future development of HCC. Moreover, early detection of AFB1 exposure, together with early vaccination against HBV and HCV can remove the synergistic effects of these two etiological factors and thus decrease the risk of developing liver cancer.

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Section: Discussioncontrasting

confidence: 53%

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Farag

Alayobi²,

Alsaleh

et al. 2016

Preprint

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“…However, Allameh et al (2005) reported that unlike non-enzymatic parameters, marker enzymes, particularly lactate dehydrogenase, and ALT showed more dependency on the concentration and duration of the exposure to aflatoxins. Therefore, in the present study, consumption of diet contaminated to 3 ppm aflatoxin for 4 weeks can be the reason for the elevation of ALT and AST.…”

Section: Discussionmentioning

confidence: 99%

“…Although in previous studies (Allameh et al, 2005;Kubena et al, 1998) expressed ALT and AST activities were considered sensitive indicators of liver lesions, but it seems that the level of these enzymes in serum mostly varied in aflatoxin-treated chickens and maybe found reduction or elevation ALT or AST in experimental aflatoxicosis. However, Allameh et al (2005) reported that unlike non-enzymatic parameters, marker enzymes, particularly lactate dehydrogenase, and ALT showed more dependency on the concentration and duration of the exposure to aflatoxins.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of turmeric (Curcuma longa) effect on biochemical and pathological parameters of liver and kidney in chicken aflatoxicosis

Gholami‐Ahangaran

Rangsaz

Azizi

2015

Pharmaceutical Biology

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Context: Aflatoxins as potent mycotoxins can influence vital parameters in chickens. Turmeric was used in decreasing toxic effect of mycotoxins on vital organs, traditionally. Objective: The study compared the protective effect of turmeric and Mycoad TR in broilers exposed to aflatoxin. Materials and methods: Chickens (270) were divided into six groups. The chickens were fed a basal diet, turmeric extract (5 mg/kg diet), Mycoad TR (25 mg/kg diet), productive aflatoxin (3 mg/kg diet), aflatoxin plus turmeric extract (3 versus 5 mg/kg diet), and aflatoxin plus Mycoad TR (3 versus 25 mg/kg diet) in basal diet. At 28 d old, we determined plasma concentration of total protein, albumin, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), calcium, potassium, phosphorous, uric acid, aspartate transferase (AST), and alanine aminotransferase (ALT). Furthermore, liver and kidney were sampled for pathological examination. Results: Chickens fed turmeric with aflatoxin had significant lower ALT, AST, and uric acid than chickens fed aflatoxin (11.4 ± 0.79, 228 ± 9, and 6 ± 0.4 versus 17.2 ± 1.7, 283 ± 5, and 7.7 ± 0.1) whereas, total protein, calcium, and HDL values in chickens fed aflatoxin plus turmeric increased significantly (2.66 ± 0.16, 8.4 ± 0.2, and 920 ± 4.1 versus 1.7 ± 0.17, 7 ± 0.2, and 690 ± 4.8). Pathological examination revealed severe congestion, degeneration, and necrosis in liver and kidney in chickens that received aflatoxin. Discussion and conclusion: The study showed that turmeric may provide protection against the toxic effects of aflatoxin on liver and kidney.ARTICLE HISTORY

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“…Chemical treatments using solvents are able to extract these compounds causing minimal effect on nutritional quality, however, this technology is still impractical and expensive, besides inducing odors and flavors. Ammoniation is also used as an effective and practical application for decontamination of agricultural products containing aflatoxins (Allameh et al, 2005). Ozonation is the chemical method that has been most studied for the decontamination of aflatoxins in foods, once ozone has been recognized as safe by the Food and Drug Administration in 2001 (Zorlugenç et al, 2008).…”

Section: Legislation Desintoxication and Controlmentioning

confidence: 99%

Aflatoxins: Contamination, Analysis and Control

Dors¹,

Caldas²,

Feddern³

et al. 2011

Aflatoxins - Biochemistry and Molecular Biology

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Evaluation of biochemical and production parameters of broiler chicks fed ammonia treated aflatoxin contaminated maize grains

Cited by 68 publications

References 21 publications

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Evaluation of turmeric (Curcuma longa) effect on biochemical and pathological parameters of liver and kidney in chicken aflatoxicosis

Aflatoxins: Contamination, Analysis and Control

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