Evaluation of behavioral change after adenotonsillectomy for obstructive sleep apnea in children with autism spectrum disorder

Murata, Eiji; Mohri, Ikuko; Kato‐Nishimura, Kumi; Iimura, Jiro; Ogawa, Makoto; Tachibana, Masaya; Ohno, Yuko; Taniike, Masako

doi:10.1016/j.ridd.2017.04.012

Cited by 17 publications

(6 citation statements)

References 45 publications

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“…In one study, adenotonsillectomyin a 5-year-old of ASD child who had OSA was found to enhance the child's social communication, sleep, and attention,and additionally reduced repetitive stereotyped behavior and hypersensitivity [99]. In another study, adenotonsillectomy treatment in ASD children with OSA improved sleep quality which A c c e p t e d M a n u s c r i p t further reduced the severity of behavioral problems [44]. Adenotonsillectomy in ASD children can stimulate anxiety-related problems,but these can be dealt with by following proper guidelines and procedures before the treatment [100].…”

Section: Suggestions For Sleep Hygiene Practicementioning

confidence: 99%

“…ASD children with obstructive sleep apnea (OSA) exhibited symptoms such as snoring with loud sounds, sleeping with an open mouth, apnea and leaning of the head backward during sleep [44]. The presence of sleep-disordered breathing has been shown to coincide with stereotyped activity, social impairment and overall severity in autism [45].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Understanding the role of sleep and its disturbances in Autism spectrum disorder

Ramanujam

Cardinali

Venkat

et al. 2020

International Journal of Neuroscience

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Sleep difficulties are one of the significant complications associated with autism spectrum disorder (ASD). Despite their possible role as contributors to the overall symptoms of ASD, the symptoms of disturbed sleep experienced by many affected patients have only recently started to receive attention from clinicians, caretakers, and family members. Many types of sleep disorders have been reported in ASD individuals, but these have not been categorized under a common terminology. Nevertheless, several studies have established that a positive relationship exists between the occurrence of sleep difficulties and heightenedsymptomatology in ASD children. When ASD children show evidence of sleep problems there is also an increased frequency of A c c e p t e d M a n u s c r i p t behavioral problems such as social impairment, decreased cognitive functioning, aggressiveness, and anxiety. Several hypotheses have been put forward regarding the linkage between disturbed sleep and ASD. These have included suggestions that sleep difficulties and other ASD symptoms are induced by disruption of the circadian clock, the presence of comorbid physical or psychological conditions, elevated anxiety levels, or emotional distress. This article reviews the use of sleep therapies in ASD, among which melatonin has shown promise because of its lack ofsignificant side effects. A better understanding of sleep problems in the etiology of ASD, their impact on the symptoms and behavior of ASD individuals, and their potential use as a secondary aid for treating ASD would represent a significant contribution todevelop strategies to manage the disorder.

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Section: Suggestions For Sleep Hygiene Practicementioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Understanding the role of sleep and its disturbances in Autism spectrum disorder

Ramanujam

Cardinali

Venkat

et al. 2020

International Journal of Neuroscience

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Section: Introductionmentioning

confidence: 99%

“…A recent article proposed a novel view on attention-deficit/hyperactivity disorder, whereby a part of the symptoms of attention-deficit/hyperactivity disorder were linked to chronic sleep disorders, with delayed circadian rhythm suggested as the underlying mechanism [ 14 ]. Furthermore, several studies on children with neurodevelopmental disorders have indicated that improvements in their sleep problems could lead to improvements in their behavioral problems [ 15 - 17 ]. However, in the context of the evidence regarding the association between sleep problems and developmental trajectories, there is a lack of clarity on whether sleep problems and the predictors of developmental disorders originally coexist or whether sleep problems in early childhood impact developmental trajectories [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Improving Children’s Sleep Habits Using an Interactive Smartphone App: Community-Based Intervention Study

Yoshizaki¹,

Murata²,

Yamamoto³

et al. 2023

JMIR Mhealth Uhealth

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Background Sleep problems are quite common among young children and are often a challenge for parents and a hinderance to children’s development. Although behavioral therapy has proven effective in reducing sleep problems in children, a lack of access to professionals who can provide effective support is a major barrier for many caregivers. Therefore, pediatric sleep experts have begun developing apps and web-based services for caregivers. Despite the substantial influence of cultural and familial factors on children’s sleep, little effort has gone into developing cultural or family-tailored interventions. Objective This study aimed to examine the effectiveness of the interactive smartphone app “Nenne Navi,” which provides culturally and family-tailored suggestions for improving sleep habits in young Japanese children through community-based long-term trials. The study also aimed to investigate the association between app-driven improvements in sleep and mental development in children. Methods This study adopted a community-based approach to recruit individuals from the Higashi-Osaka city (Japan) who met ≥1 of the following eligibility criteria for sleep problems: sleeping after 10 PM, getting <9 hours of nighttime sleep, and experiencing frequent nighttime awakenings. A total of 87 Japanese caregivers with young children (mean 19.50, SD 0.70 months) were recruited and assigned to the app use group (intervention group) or the video-only group (control group). Both groups received educational video content regarding sleep health literacy. The caregivers in the intervention group used the app, which provides family-tailored suggestions, once per month for 1 year. Results A total of 92% (33/36) of the caregivers in the app use group completed 1 year of the intervention. The participants’ overall evaluation of the app was positive. The wake-up time was advanced (base mean 8:06 AM; post mean 7:48 AM; F1,65=6.769; P=.01 and sleep onset latency was decreased (base mean 34.45 minutes; post mean 20.05 minutes; F1,65=23.219; P<.001) significantly in the app use group at the 13th month compared with the video-only group. Moreover, multiple regression analysis showed that decreased social jetlag (β=−0.302; P=.03) and increased sleep onset latency SD (β=.426; P=.02) in children predicted a significant enhancement in the development of social relationships with adults. At 6 months after the completion of the app use, all the caregivers reported continuation of the new lifestyle. Conclusions The present findings suggest that the app “Nenne Navi” has high continuity in community use and can improve sleep habits in young Japanese children and that interventions for sleep habits of young children may lead to the enhancement of children’s social development. Future studies must focus on the effectiveness of the app in other regions with different regional characteristics and neuroscientific investigations on how changes in sleep impact brain development.

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“…As in the general pediatric population, 8 adenotonsillectomy may improve daytime behaviors in children with ASD and OSA. 9 Therefore, being able to predict which children with ASD are at risk for OSA is not only important for improving the health of children with ASD but also their daytime functioning and development in social communication.…”

mentioning

confidence: 99%

Can We Predict Which Children With Autism Will Have Obstructive Sleep Apnea?

Singer

Shelton

Malow

2019

Journal of Clinical Sleep Medicine

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Evaluation of behavioral change after adenotonsillectomy for obstructive sleep apnea in children with autism spectrum disorder

Abstract: Behavioral problems were significantly improved following AT in ASD children with OSA. Early detection and treatment of children with OSA is essential to prevent behavioral problems and to support mental development.

Cited by 17 publications

References 45 publications

Understanding the role of sleep and its disturbances in Autism spectrum disorder

Understanding the role of sleep and its disturbances in Autism spectrum disorder

Improving Children’s Sleep Habits Using an Interactive Smartphone App: Community-Based Intervention Study

Can We Predict Which Children With Autism Will Have Obstructive Sleep Apnea?

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