volume 70, issue 1, P15-24 2001
DOI: 10.5025/hansen.70.15
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Abstract: The cell activation depends on T cell antigen receptor binding to antigen plus MHC and costimulation. The binding of CD28, expressed on the T cell surface to B7 (B7-1 or CD80 / B7-2 or CD86) present on the antigen presenting cells (APCs), determines , in several T cell function models, if activation or anergy follows antigenic stimulation. In leprosy, the role of CD80 and CD86 as costimulatory signal in M. leprae specific cellular immunity has not yet been defined. We investigated the role of B7-CD28 pathway o…

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