Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission

Aghdasi-Bornaun, Helen; Kutluk, Günsel; Keskindemirci, Gonca; Öztarhan, Kazım; Dedeoğlu, Reyhan; Yılmaz, Nuh; Tosun, Öykü

doi:10.24953/turkjped.2018.04.008

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…Heart Rate Variability (HRV) is one of the reliable and non-invasive approaches to evaluate the autonomic control of the cardiovascular system in healthy individuals as well as patients with the cardiovascular disorder [25]. Although the correlation of the sympathovagal modulation is not a consensus on chronic inflammatory processes, the vagus nerve may be correlated with inflammation using two pathways.…”

Section: Diseasesmentioning

confidence: 99%

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis

Ribeiro

Araújo

Bueno

et al. 2019

Preprint

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Background The Denture-related stomatitis (DS) is a chronic multifactorial inflammation, strongly related to the presence of the biofilm. This oral condition has recently been correlated with deleterious cardiovascular alterations. The potential effect of hygiene protocols in the control of DS and Randomized clinical trials that address this oral condition with cardiovascular complications are necessary for clinical decision-making. Material/design A clinical trial, randomized, double-blind, of parallel groups, will be conducted in Brazil and the sample will be composed of 100 total edentulous individuals bi-maxillary, users of at least maxillary complete dentures, diagnosed with DS that will be allocated according to the different hygiene protocols: (1) brushing of the palate and immersion of the prosthesis in 0.25% sodium hypochlorite solution (positive control); (2) brushing of the palate and immersion of the prosthesis in 0.15% Triclosan solution; (3) brushing of the palate and immersion of the prostheses in lactose monohydrate; (4) brushing the palate with citric acid and immersing the prosthesis in lactose monohydrate. The response variables will be: heart rate variability and alteration of blood pressure (systemic level), remission of Denture-related Stomatitis, removal of biofilm, reduction of microbial load (CFU), mouth and prosthesis odor level, expression of MUC1, proinflammatory cytokines, C-reactive protein level -CRP, viscosity, pH and salivary flow (locally).Measurements will be performed in the Baseline and ten days after the interventions. The results obtained will be submitted to the pertinent statistical analysis with a level of significance of 0.05.Discussion This study will provide a guideline of clinical practice regarding the use of hygiene protocols in the treatment of oral diseases mediated by biofilm. Also, it may provide evidence of correlation of oral manifestation with cardiac risk.

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Section: Diseasesmentioning

confidence: 99%

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis

Ribeiro

Araújo

Bueno

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Heart rate variability (HRV) is one of the reliable and non-invasive approaches used to evaluate the autonomic control of the cardiovascular system in healthy individuals and in patients with the cardiovascular disorder [25]. Although there is no consensus on correlation between sympathovagal modulation and chronic inflammatory processes, there might be correlation between the vagus nerve and inflammation through two pathways.…”

Section: Introductionmentioning

confidence: 99%

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol

Ribeiro

Araújo

Silva

et al. 2019

Trials

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BackgroundDenture-related stomatitis (DS) is chronic multifactorial inflammation, strongly related to the presence of the biofilm that is the complex structure formed by microorganisms held together by a mucus-like matrix of carbohydrate that adheres to different surfaces, including the denture surface. DS has recently been correlated with deleterious cardiovascular alterations. The potential effect of hygiene protocols in the control of DS and randomized clinical trials that address this oral condition with cardiovascular complications are important in clinical decision-making.Material/designA clinical trial, randomized, double-blind, and with parallel groups, will be conducted in Brazil The sample will consist of 100 patients without teeth in both arches, users of at least maxillary complete dentures, and diagnosed with DS, who will be allocated to groups (n = 25 per group) according to the different hygiene protocols: (1) brushing of the palate and immersion of the prosthesis in 0.25% sodium hypochlorite solution (positive control); (2) brushing of the palate and immersion of the prosthesis in 0.15% triclosan solution; (3) brushing of the palate and immersion of the prosthesis in lactose monohydrate; or (4) brushing the palate with citric acid and immersing the prosthesis in lactose monohydrate. The response variables will be heart rate variability and alteration of blood pressure (systemic level), remission of DS, removal of biofilm, reduction of microbial load (colony-forming units (CFU)), mouth and prosthesis odor level, expression of MUC1, proinflammatory cytokines, C-reactive protein (CRP), viscosity, pH and salivary flow (locally); patient-centred qualitative analysis will also be undertaken. Measurements will be performed at baseline and 10 days after the interventions. The results obtained will be statistically analyzed as pertinent, with a level of significance of 0.05.DiscussionThis study will provide a guideline for clinical practice regarding the use of hygiene protocols in the treatment of oral diseases (DS) mediated by biofilm. Also, it may provide evidence of correlation of oral manifestation with cardiac risk.Trial registrationBrazilian Registry of Clinical Trials, RBR-4hhwjb. Registered on 9 November 2018.

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Urbanization Effect on Children’s Autonomic Nervous System

Berezhanskiy

Tataurschikova

2021

Springer Geography

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Evaluation of autonomic nervous system functions in frame of heart rate variability in children with inflammatory bowel disease in remission

Cited by 8 publications

References 18 publications

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis

Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis - a randomized, double-blind trial protocol

Urbanization Effect on Children’s Autonomic Nervous System

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