Evaluation of Autologous Platelet Rich Fibrin in Cleft Palate Repair

Soliman, Soliman M.; Mahmoud, Abdelaziz Yehya; Elsayed, Ahmed Abdelaal; Hashish, Mahmoud; Mohammed, Mohammed Fawzy Saleh

doi:10.21608/ejhm.2019.63231

Cited by 4 publications

(9 citation statements)

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“…Rates of fistula formation following primary palatoplasty varies from 3 and 45% and several methods have been developed to limit its incidence. [ 7 ] These methods include: total release of the tensor tendon, relaxing incisions with complete intravelar veloplasty with combination of acellular dermal matrix to achieve complete nasal lining repair. [ 10 ] The closure of oronasal fistulas is often made difficult by the unavoidable mucosal scarring that results from primary attempts at repair and scarcity of adequate soft tissue surrounding the defect.…”

Section: Discussionmentioning

confidence: 99%

“…[ Figure 1 ] showed the defect due to the removal of scar tissue around the fistula which is similar to those reported by Soliman et al . [ 7 ] Early closure of ONF is usually advised to forestall oronasal fluid leakage, halitosis and speech problems.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] Failure of primary defect repair makes it more likely for fistula to recur as a result of fibrosis and decreased vascularization associated with each of the repeated surgeries. [ 7 ] Various aetiologic factors have been linked to the formation of ONF. They include wound breakdown as a result of closure site tension, post-operative flap trauma, infection, hematoma and hypoxemia[ 4 5 6 7 ] This has made the closure of ONF a challenge to both the patient and the surgeon.…”

Section: Introductionmentioning

confidence: 99%

“…[ 7 ] Various aetiologic factors have been linked to the formation of ONF. They include wound breakdown as a result of closure site tension, post-operative flap trauma, infection, hematoma and hypoxemia[ 4 5 6 7 ] This has made the closure of ONF a challenge to both the patient and the surgeon. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

“…They stimulate bone regeneration from undifferentiated mesenchymal cells. [ 7 ] The aim of this article is to share our experience in the repair of ONF using PRF as an adjunct which to the best of our knowledge is the first from our region.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Role of platelet rich fibrin in the closure of oronasal fistula. A case report

Taiwo

Braimah

Ile-Ogendengbe

et al. 2022

J West Afr Coll Surg

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An oronasal fistula is an abnormal opening connecting the oral cavity and the nose. They could occur as complications of oral and maxillofacial procedures. Oronasal fistulas (ONF) are challenging to repair optimally. The repair of a recurrent ONF is more of an enigma in cases where a small defect often requires an extensive surgery to close. Platelet rich fibrin (PRF) was described by Choukroun as a platelet concentrate from autologous blood which forms a single fibrin biomaterial after centrifugation. This haemostatic plug rich in growth factors is easy to prepare, manipulate; and adapt for soft and hard tissue healing. It has been utilized in the various fields of dentistry especially oral and maxillofacial surgery. Reports of role of PRF in the repair of ONF closure are scarce in literature especially in conjunction with other soft tissue flaps. This case report highlights that PRF can be used with success as an adjunct for the closure of ONF fistulas.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of platelet rich fibrin in the closure of oronasal fistula. A case report

Taiwo

Braimah

Ile-Ogendengbe

et al. 2022

J West Afr Coll Surg

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Effect of adjuvant autologous platelet concentrates on secondary repair of alveolar clefts: A systematic review and meta‐analysis

Siddiqui

Sennimalai

Bhatt

et al. 2023

Special Care in Dentistry

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ObjectiveTo review the existing evidence on the adjuvant use of autologous platelet concentrates (APCs) with iliac crest bone graft (ICBG) in the reconstruction of the secondary alveolar cleft.MethodsElectronic databases were searched systematically until November 2022. Clinical trials comparing the three‐dimensional radiological outcomes of patients who underwent secondary alveolar bone grafting (SABG) with ICBG and APCs to those with ICBG alone and the radiological outcomes assessed 6 months after surgery were included. Two authors performed the study selection and the assessment of the risk of bias. Meta‐analysis was performed using the random‐effects model to determine the risk ratio (RR) for developing wound dehiscence and the mean difference (MD) with a 95% confidence interval (CI) for the percentage of newly formed bone.ResultsNine studies (seven RCT and two CCT) were included with a low to high risk of bias. At the 6‐month follow‐up, the study group revealed insignificant results regarding the percentage of newly formed bone (MD = 6.49; 95% CI: −0.97, 13.94; p = .09; χ2 = 0.01; I2 = 71%). In addition, the overall risk of developing wound dehiscence was lower in the study group (RR = 0.34; 95% CI: 0.15, 0.78; p = .01; χ2 = 0.67; I2 = 0%).ConclusionCurrently, there is insufficient evidence to support the adjuvant use of APCs with ICBG on enhanced bone regeneration following secondary alveolar bone grafting. However, combining ICBG and APCs might be beneficial in reducing the risk of developing wound dehiscence.

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Predictors of Success After Furlow Palatoplasty for Repair of Cleft Palate: Does Syndrome Matter?

Evans

Bly

Paulsgrove

et al. 2021

Otolaryngol.--head neck surg.

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Objective To determine predictors of success following Veau 1 and 2 cleft palate repair in patients with and without syndromes. Study Design Retrospective review of prospectively collected data. Setting Tertiary care children’s hospital. Methods All children <18 months of age undergoing Furlow palatoplasty for Veau 1 and 2 cleft repair between 2000 and 2014 with postoperative perceptual speech assessment (PSA). Results In total, 368 consecutive patients were identified; 95 were excluded, resulting in 273 patients. Median age at surgery was 13.0 months (interquartile range [IQR], 11-15 months) with postoperative PSA at a median of 32.3 months (IQR, 26.3-44.5 months). Fifty patients (18.3%) had syndrome diagnosis; 59 patients (21.6%) had nonsyndromic Robin sequence. Velopharyngeal insufficiency (VPI) occurred in 27 patients (10.5%); 13 underwent secondary speech surgery. Cleft-related speech errors occurred in 46 patients (17.6%). Non-cleft-related speech errors occurred in 155 patients (59.6%) and reduced intelligibility in 127 patients (47.9%). Oronasal fistula occurred in 23 patients (8.8%) and was exclusive to Veau 2 clefts. In multivariate analysis, age >13 months at palatoplasty demonstrated a 6-fold higher rate of VPI (hazard ratio [HR], 6.64; P < .01), worse speech outcomes (HR, 6.04; P < .01; HR, 1.60; P < .01; HR, 1.57; P = .02), and greater speech therapy utilization (HR, 2.18; P < .01). Conclusion VPI occurred in 10% of patients undergoing Furlow palatoplasty repair of Veau 1 or 2 clefts. Age <13 months at palatoplasty was associated with improved speech outcomes and lower VPI incidence (2.8% vs 16.2%). Syndromic diagnosis was associated with noncleft speech errors and reduced intelligibility on univariate analysis but not velopharyngeal function after palatoplasty.

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Evaluation of Autologous Platelet Rich Fibrin in Cleft Palate Repair

Cited by 4 publications

References 0 publications

Role of platelet rich fibrin in the closure of oronasal fistula. A case report

Role of platelet rich fibrin in the closure of oronasal fistula. A case report

Effect of adjuvant autologous platelet concentrates on secondary repair of alveolar clefts: A systematic review and meta‐analysis

Predictors of Success After Furlow Palatoplasty for Repair of Cleft Palate: Does Syndrome Matter?

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