Evaluation of autoimmune thyroid disease in melasma

Mogaddam, Majid Rostami; Alamdari, Manouchehr Iranparvar; Maleki, Nasrollah; Ardabili, Nastaran Safavi; Abedkouhi, Selma

doi:10.1111/jocd.12138

Cited by 18 publications

(15 citation statements)

References 17 publications

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“…Just two studies had investigated the relationship between FT3 and melasma, both of which were performed among women. The pooled mean difference of FT3 was estimated to be 0.16 (−0.10, 0.42) (table ) . In addition, there was no heterogeneity between the results of these primary studies ( I ‐squared = 0, Q = 0.14, P = 0.704).…”

Section: Resultsmentioning

confidence: 95%

“…performed a study characterized by representative and well‐defined cases. Controls were also well‐defined and disease‐free but had no clear origin . Groups were age‐matched …”

Section: Resultsmentioning

confidence: 99%

“…There was no heterogeneity between the results of the primary studies regarding the association between melasma and TSH ( I ‐squared = 0, Q = 3.86, P = 0.695). Among these primary studies, five studies had been carried out among women . The combined mean difference of TSH in these five studies was estimated to be 0.35 (0.17, 0.52) ( I ‐square = 0, Q = 3.25, P = 0.517).…”

Section: Resultsmentioning

confidence: 99%

“…Coherently with its poor pathogenetic understanding and its tendency to relapse, melasma treatments are challenging and often followed by low patient satisfaction . Recent findings suggest that thyroid hormones may play a key role in melasma; this idea has also been sustained by a few epidemiological studies . In literature, thyroid disorders are associated with several disorders affecting the pigmentation, as vitiligo and leukoderma, or inflammatory, as eczema …”

Section: Introductionmentioning

confidence: 99%

“…Thyroid disorder is a clinical situation following reduction or elevation of the serum thyroid hormones. Several studies have been published regarding the association between melasma and thyroid hormones reporting different results . For example, Cakmak et al .…”

Section: Introductionmentioning

confidence: 99%

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Melasma and thyroid disorders: a systematic review and meta‐analysis

et al. 2019

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AbstractsBackground Thyroid hormones may play a key role in melasma; however, melasma link with thyroid disorders remains controversial.Objectives To compare the serum levels of thyroid-stimulating hormone (TSH), T4, T3, anti-thyroid peroxidase (anti-TPO), and antithyroglobulin between patients with melasma and control group using meta-analysis.Methods We screened 10 databanks and search engines, searched mesh and nonmesh terms. The identified evidences were reviewed and quality assessed using the Newcastle-Ottawa Scale (NOS). The heterogeneity between the primary results was investigated using Cochrane and I-square indices. Random effect model was applied to combine the standardized mean differences of thyroid function indicators between patients with and without melasma. P values meta-analysis was used to investigate the association between anti-TPO and melasma. ResultsWe included seven studies, 473 cases, and 379 controls that had been investigated. The total standardized mean differences (95% confidence intervals) of TSH, T3, T4, and antithyroglobulin antibody between cases and controls were estimated to be 0.33 (0.18, 0.47), À0.01 (À0.20, 0.19), À1.50 (À2.96, À0.04), and 0.62 (0.14, 1.11), respectively. The corresponding figures among women were 0.35 (0.17, 0.52), 0.10 (À0.17, 0.38), À2.75 (À6.30, 0.81), and 0.99 (0.14, 1.83), respectively. P value of metaanalysis showed a significant relationship between anti-TPO serum level and melasma (Fisher = 26.80, P = 0.020).Conclusion Serum levels of TSH, anti-TPO, and antithyroglobulin antibody were significantly higher in patients with melasma than those without melasma. Moreover, these differences were more severe among women with melasma. What is new?• Melasma is an acquired type of hyperpigmentation and might be associated with thyroid disorders.• Results of the present study showed that serum levels of TSH, anti-thyroid peroxidase (anti-TPO), and antithyroglobulin antibody were significantly higher in patients with melasma than those without melasma. Moreover, these differences were more severe among women with melasma.• Serum levels of TSH, anti-TPO, and antithyroglobulin antibodies are associated with melasma, especially among women. Risk of biasThe Newcastle-Ottawa Scale (NOS) checklist was applied to determine the risk of bias in primary studies. This checklist evaluates the studies in three section including selection (four scores), comparability (two scores), and exposure (three scores). Each study was achieved between 0 and 9 scores, and studies with less than five scores were removed from the metaanalysis. The quality assessment was performed by two independent methodologists. 20

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Section: Resultsmentioning

confidence: 95%

“…performed a study characterized by representative and well‐defined cases. Controls were also well‐defined and disease‐free but had no clear origin . Groups were age‐matched …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melasma and thyroid disorders: a systematic review and meta‐analysis

et al. 2019

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Fractional 1064 nm Picosecond Laser in Treatment of Melasma and Skin Rejuvenation in Asians, A Prospective Study

et al. 2021

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Background and Objectives Facial melasma is a disfiguring pigmentation and occurs frequently with aging skin. Topical treatment alone was often suboptimal. A recent study showed that fractional picosecond laser has promising result in benign pigmentary lesions. This study aims to investigate the efficacy and safety of 1064 nm picosecond laser in treatment of facial melasma and skin rejuvenation in Asian skin. Study Design/Materials and Methods Patients of Asian descent seeking treatment for facial melasma and skin rejuvenation were screened and recruited. Each patient received up to nine laser treatments at 4–6 weeks intervals with a fractionated nonablative 1064 nm picosecond laser. Baseline and posttreatment modified Melasma Area Severity Index (mMASI) and Global Aesthetic Improvement Scale (IGAS) were assessed by blinded investigators based on the clinical photographs. Subject overall satisfaction was assessed by the questionnaires after treatment. All adverse events were documented. Results Twenty patients were recruited with a median age of 52.7 ± 8.2 years. Three subjects had Fitzpatrick skin type III and 17 had skin type IV. All subjects received nine laser sessions. Over 70% of patients were satisfied with the treatment outcomes. There was a statistically significant improvement in mMASI which reduced from 10.8 at baseline to 2.7 and 3.6 at 6 and 12 weeks post‐treatment, respectively (both P < 0.01). For skin rejuvenation, 70% reported at least a moderate improvement at 6 weeks of post‐treatment. No major side‐effect was reported. Erythema was the most frequent transient response, while some reported edema (1.1%). Both resolved spontaneously. None reported hypo‐ or hyperpigmentation after treatment. The overall mean pain scare (VAS) was 1.92. Conclusion Fractionated non‐ablative 1064 nm picosecond laser was effective in treatment of melasma and skin rejuvenation. It was also safe and well tolerated. Importantly, there was no hypo or hyperpigmentation reported. Lasers Surg. Med. 00:00–00, 2021. © 2021 Wiley Periodicals LLC

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Melasma and Comorbidities

Dlova

Naidoo

2017

Melasma and Vitiligo in Brown Skin

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Evaluation of autoimmune thyroid disease in melasma

Cited by 18 publications

References 17 publications

Melasma and thyroid disorders: a systematic review and meta‐analysis

Melasma and thyroid disorders: a systematic review and meta‐analysis

Fractional 1064 nm Picosecond Laser in Treatment of Melasma and Skin Rejuvenation in Asians, A Prospective Study

Melasma and Comorbidities

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