Evaluation of arterial stiffness in children with type 1 diabetes using the oscillometric method

Terlemez, Semiha; Bulut, Yasin; Ünüvar, Tolga; Tokgöz, Yavuz; Eryılmaz, Ufuk; Çelik, Bülent

doi:10.1016/j.jdiacomp.2016.03.012

Cited by 17 publications

(16 citation statements)

References 33 publications

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“…It is also important to note that the glycemic control in our cohort was suboptimal with a mean HbA1c of 9.0 ± 1.5%. Poor glycemic control is a well‐known risk factor of arterial stiffness in adolescents and adults with diabetes . Although our adolescents with T1D had higher copeptin concentrations compared to controls, the study by Shiel et al found no significant differences in copeptin concentrations between participants with and without T1D.…”

Section: Discussioncontrasting

confidence: 72%

“…Poor glycemic control is a well-known risk factor of arterial stiffness in adolescents and adults with diabetes. [26][27][28] Although our adolescents with T1D had higher copeptin concentrations compared to controls, the study by Shiel et al found no significant differences in copeptin concentrations between participants with and without T1D. This discrepancy may relate to the better glycemic control in their participants with T1D.…”

Section: Discussioncontrasting

confidence: 58%

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Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes

et al. 2019

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Objective We sought to evaluate copeptin concentrations in adolescents with and without type 1 diabetes (T1D) and examine the associations between copeptin and measures of arterial stiffness and kidney dysfunction. Research design and methods This analysis included 169 adolescents with T1D (12‐19 years of age, 59% girls, mean HbA1c 9.0 ± 1.5% and diabetes duration of 8.6 ± 2.9 years), in addition to 61 controls without T1D. Arterial stiffness including carotid‐femoral pulse wave velocity (CF‐PWV), carotid‐radial PWV (CR‐PWV), augmentation index normalized to heart rate of 75 bpm (AIx@HR75), and brachial artery distensibility (BAD). Serum copeptin, urinary albumin‐to‐creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were also assessed. Results Compared to controls, adolescents with T1D had higher median (Q1‐Q3) copeptin (7.5 [5.2‐11.3] vs 6.4 [4.8‐8.3] pmol/L, P = .01), mean ± SD eGFR (121 ± 23 vs 112 ± 16 mL/min/1.73m2, P = .002) and lower BAD (7.1 ± 1.3 vs 7.2 ± 1.2%, P = .02). Adolescents with T1D in the in high tertile copeptin group (>9.1 pmol/L) had higher AIx@HR75 (10.7 ± 1.2 vs 5 ± 1.2, P = .001), CR‐PWV (5.30 ± 1.0 vs 5.18 ± 1.0 m/s, P = .04), and UACR (12 ± 1 vs 8 ± 1 mg/g, P = .025) compared to those in low tertile (<5.8 pmol/L) after adjusting for age, sex, and eGFR. Copeptin inversely associated with CF‐PWV independent of age, sex, eGFR, SBP, and HbA1c in T1D adolescents. Conclusions Our data demonstrate that elevated copeptin was associated with worse arterial stiffness in adolescents with T1D. These findings suggest that copeptin could improve CVD risk stratification in adolescents with T1D.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussioncontrasting

confidence: 58%

Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes

et al. 2019

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“…For example, in the SEARCH Cardiovascular Study, 33% of adolescents with T1D had increased peripheral (brachial) arterial stiffness but only 10% had increased central (aorto‐femoral) PWV . Other studies that measured arterial compliance in the radial artery reported stiffer vessels in adolescents with T1D, whereas a study using brachial‐ankle PWV (a measure of central stiffness) reported no difference between T1D and control participants . Thus, the available evidence suggests that arterial stiffening in young people with T1D may begin earlier, or is more prominent in peripheral vessels compared to central vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Arterial compliance is a predictor of cardiovascular disease and mortality. Arterial compliance is often, though not always, reduced in adolescents with T1D . The autonomic nervous system regulates heart rate and vascular tone and is also impacted by T1D.…”

Section: Introductionmentioning

confidence: 99%

A pilot study of the effects of a high‐intensity aerobic exercise session on heart rate variability and arterial compliance in adolescents with or without type 1 diabetes

et al. 2020

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Arterial compliance and autonomic regulation are predictors of cardiovascular disease.In adults, both are altered chronically by type 1 diabetes (T1D) and acutely by exercise; however, the effects of T1D and exercise are less clear in adolescents. We measured short-term effects of a high-intensity aerobic interval exercise session on cardiovascular and metabolic variables in normal weight adolescents with T1D or without T1D (Control). Energy expenditure (EE), heart rate variability (HRV), arterial compliance, and blood pressure (BP) were measured before exercise (baseline) and three times over 105 minutes postexercise. The T1D and control groups had similar cardiorespiratory

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“…Aortic pulse wave velocity (PWV) has also been used to assess aortic wall stiffness [12][13][14]. Recent studies point to the utility of assessing arterial stiffness by PWV, in children with varied congenital heart and vascular malformations [15][16][17]. Studies reveal stiffer, less compliant thoracic aortas and impaired arterial stiffness in adolescents with T1DM.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive assessment of coronary endothelial function in children and adolescents with type 1 diabetes mellitus using isometric handgrip exercise—MRI: A feasibility study

Zwingli

Yerly²,

Mivelaz

et al. 2020

PLoS ONE

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Background Type 1 diabetes mellitus (T1DM) in children and adolescents is associated with significant cardiovascular morbidity and mortality. Early detection of vascular dysfunction is key to patient management yet current assessment techniques are invasive and not suitable for pediatric patient populations. A novel approach using isometric handgrip exercise during magnetic resonance imaging (IHE-MRI) has recently been developed to evaluate coronary endothelial function non-invasively in adults. This project aimed to assess endotheliumdependent coronary arterial response to IHE-MRI in children with T1DM and in age matched healthy controls. Materials and methods Healthy volunteers and children with T1DM (>5 years) were recruited. IHE-MRI cross-sectional coronary artery area measurements were recorded at rest and under stress. Carotid intima media thickness (CIMT) and aortic pulse wave velocity (PWV) were assessed for comparison. Student's t-tests were used to compare results between groups. Results and discussion Seven children with T1DM (3 female, median 14.8 years, mean 14.8 ± 1.9 years) and 16 healthy controls (7 female, median 14.8 years, mean 14.2 ± 2.4 years) participated. A significant increase in stress-induced cross-sectional coronary area was measured in controls

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Evaluation of arterial stiffness in children with type 1 diabetes using the oscillometric method

Cited by 17 publications

References 33 publications

Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes

Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes

A pilot study of the effects of a high‐intensity aerobic exercise session on heart rate variability and arterial compliance in adolescents with or without type 1 diabetes

Non-invasive assessment of coronary endothelial function in children and adolescents with type 1 diabetes mellitus using isometric handgrip exercise—MRI: A feasibility study

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