Evaluation of aquaplast splinting thermoplastic—use in a burns unit

Fowler, Diane; Pegg, Shane

doi:10.1016/0305-4179(83)90059-1

Cited by 5 publications

(5 citation statements)

References 1 publication

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“… 3,4 Once hardened at room temperature, it regains a significant amount of tensile strength, as evidenced by its application in preventing wound contractures in burn patients. 5 …”

Section: Discussionmentioning

confidence: 99%

“…3,4 Once hardened at room temperature, it regains a significant amount of tensile strength, as evidenced by its application in preventing wound contractures in burn patients. 5 We have had a positive experience in the use of Aquaplast as a temporary surgical obturator after palatectomy and maxillectomy (10 patients) as the first step in pros-thetic rehabilitation of these patients. We have encountered no adverse outcomes from its fabrication or application.…”

Section: Discussionmentioning

confidence: 99%

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An Effective, Inexpensive, Temporary Surgical Obturator Following Maxillectomy

Ducic

2001

The Laryngoscope

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“… 3,4 Once hardened at room temperature, it regains a significant amount of tensile strength, as evidenced by its application in preventing wound contractures in burn patients. 5 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An Effective, Inexpensive, Temporary Surgical Obturator Following Maxillectomy

Ducic

2001

The Laryngoscope

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“…Absence of covalent crosslinking and biodegradable nature promote easy removal of polymer from in vivo , soon after release . Pluronic or Poloxamers are ABA triblock copolymers in which A block is made of polyethylene glycol and B block is made of polypropylene glycol (PPG) . They have been widely studied as an injectable hydrogel system for protein, DNA, and drug delivery applications .…”

Section: Introductionmentioning

confidence: 99%

“…16,17 Pluronic or Poloxamers are ABA triblock copolymers in which A block is made of polyethylene glycol and B block is made of polypropylene glycol (PPG). 18 They have been widely studied as an injectable hydrogel system for protein, DNA, and drug delivery applications. [19][20][21] However, nonbiodegradable nature of pluronics offers long-term accumulation in the body, which limits its application as a drug delivery vehicle 22 .…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive biodegradable PEG‐PCL‐PEG based injectable hydrogel for pulsatile insulin delivery

Payyappilly

Dhara

Chattopadhyay

2013

J Biomedical Materials Res

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An injectable biodegradable hydrogel was prepared for temperature-responsive pulsatile release of insulin. Triblock copolymer of poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) was prepared by ring opening bulk copolymerization and characterized using FT-IR, (1) HNMR, and gel permeation chromatography. Aqueous solution of PECE formed an injectable hydrogel, which was solution at room temperature and transformed into gel at 37°C. The temperature-responsive sol-gel transition and crystallinity of PECE hydrogel was studied and compared with pluronic, a well-studied nonbiodegradable injectable hydrogel. In vitro release study revealed that insulin release profile of PECE was similar to pluronic, and its viscosity was 1/30(th) of pluronic sol at 10,000 s(-1) shear rate. Release behavior of insulin from PECE hydrogels followed Fickian diffusion of first order. Insulin retained its secondary structure after release as confirmed by circular dichroism spectrum. A threefold increase in Fickian diffusion coefficient was evidenced when temperature was increased from 34 to 40°C because of crystalline melting of PCL part of PECE. Pulsatile release of insulin showed a correlation coefficient of 0.90 with the change of temperature.

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“…The treatment of such wounds often involves a combination of surgery and splinting therapy [ 2 ]. A variety of splints, including the thermoplastic static neck splint [ 3 ], the Watusi collar [ 4 ], manually fabricated splints, and pre-fabricated splints such as the Philadelphia collar have been used for the management of scar contractures. However, each type of splint has its own advantages and disadvantages, and none of these splints seem to reduce the need for skin reconstruction nor delays the time until surgical reconstruction [ 5 ].…”

mentioning

confidence: 99%