Evaluation of Antiulcer Activity of Mucuna Pruriens by in Vivo Method

Abstract

The traditional system of medicine has developed faith and pronounced as effective and safe method of treatment. Mucuna pruriens use to treat impotence, diabetes mellitus and has anti-ulcer activity. On the other side NSAID's (Non-Steroidal Anti-inflammatory Drugs) is popular group of medicament use to treat inflammation and pain. Aspirin is the most common NASID in the practice which is well known to cause gastrointestinal ulcers. To evaluate the antiulcer activity of aqueous extract of Mucuna pruriens in aspirin induced ulcers. Preparation of extracts separately with Petroleum ether, alcohol and water. A total of thirty adult albino wistar rats were divided into four groups to evaluate the anti-ulcer effect. Group 1 Aspirin control (150 mg/kg) Group 2 Aspirin + Standard drug (Pantoprazole 40 mg/kg/per oral) Group 3 Aspirin + Mucuna pruriens aqueous extract (200mg/kg body weight) Group 4: Aspirin + Mucuna pruriens aqueous extract (400mg/kg body weight). The aqueous extract of Mucuna pruriens showed a dosedependent protection against Aspirin induced gastric ulceration. The extract protected the rat stomach from ulceration by 58.3% at a dose of 200 mg/kg body wt. (P≤0.001) and this increased to 86.8 (P≤0.001) at 400 mg/kg body wt. as compared to solvent treated rats, respectively. This was the same percentage protection as 40 mg/kg body wt. of the proton pump inhibitor like pantoprazole. Mucuna pruriens showed significant antiulcer activity in experimentally induced ulcer in rat model by decreasing the gastric secretions and by enhancing glycoprotein levels.