Evaluation of antirotavirus activity of flavonoids

Savi, Luciane Anita; Caon, Thiago; Oliveira, Ana Paula de; Sobottka, Andréa Michel; Werner, Wolfgang; Reginatto, Flávio Henrique; Schenkel, Eloir Paulo; Barardi, Célia Regina Monte; Simões, Cláudia Maria Oliveira

doi:10.1016/j.fitote.2010.07.017

Cited by 29 publications

(19 citation statements)

References 33 publications

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“…It has been previously reported that flavonoids exert their antiviral effects via blockage of cellular receptors, inhibiting viral antigenic determinants, loss of enzymatic functions, and/or inhibition of particle biosynthesis which is consistent with our findings (23)(24)(25). Furthermore, the antiviral activity of specific flavonoid subclass groups, such as catechins, flavanones, flavonols has been reported previously against various viral strains (26,27). Song et al (2005) reported reduced viral infectivity by catechins (26).…”

Section: Resultsmentioning

confidence: 82%

Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA

Adem¹,

Eyupoglu²,

Sarfraz³

et al. 2020

Preprint

174

169

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COVID-19, a rapidly spreading new strain of coronavirus, has affected more than 150 countries and received worldwide attention. The lack of efficacious drugs or vaccines against SARS-CoV-2 has further worsened the situation. Thus, there is an urgent need to boost up research for the development of effective therapeutics and affordable diagnostic against COVID-19. The crystallized form of SARS-CoV-2 main protease (Mpro) was demonstrated by a Chinese researcher Liu et al. (2020) which is a novel therapeutic drug target. This study was conducted to evaluate the efficacy of medicinal plant-based bioactive compounds against COVID-19 Mpro by molecular docking study. Molecular docking investigations were performed by using Molegro Virtual Docker 7 to analyze the inhibition probability of these compounds against COVID-19. COVID-19 Mpro was docked with 80 flavonoid compounds and the binding energies were obtained from the docking of (PDB ID: 6LU7: Resolution 2.16 Å) with the native ligand. According to obtained results, hesperidin, rutin, diosmin, apiin, diacetylcurcumin, (E)-1-(2-Hydroxy-4-methoxyphenyl)-3-[3-[(E)-3-(2-hydroxy-4- methoxyphenyl)-3-oxoprop-1-enyl]phenyl]prop-2-en-1-one, and beta,beta'-(4-Methoxy-1,3- phenylene)bis(2'-hydroxy-4',6'-dimethoxyacrylophenone have been found as more effective on COVID-19 than nelfinavir. So, this study will pave a way for doing advanced experimental research to evaluate the real medicinal potential of these compounds to cure COVID-19.

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Section: Resultsmentioning

confidence: 82%

Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA

Adem¹,

Eyupoglu²,

Sarfraz³

et al. 2020

Preprint

174

169

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“…This genus is found to be a rich source of bioactive secondary metabolites, including oxygenated prenylated xanthones and benzophenones, flavonoids, biflavonoids and triterpenes . These chemical constituents are well known for their pharmacological potential including antimicrobial, anti‐HIV, anticancer, anti‐inflammatory and hepatoprotective activities . Garcinia hombroniana , a seashore mangosteen in Malaysia, is used as a protective medicine after child birth and to cure skin allergies …”

Section: Introductionmentioning

confidence: 99%

Complete NMR assignments of bioactive rotameric (3 → 8) biflavonoids from the bark of Garcinia hombroniana

Jamila

Khairuddean

Khan

et al. 2014

Magnetic Reson in Chemistry

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The genus Garcinia is reported to possess antimicrobial, anti-inflammatory, anticancer, hepatoprotective and anti-HIV activities. Garcinia hombroniana in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to isolate the chemical constituents from the bark of G. hombroniana and explore their possible pharmacological potential. Ethyl acetate extract afforded one new (1) and six (2-7) known 3 → 8 rotameric biflavonoids. Their structures were elucidated by UV, IR and NMR (1D and 2D) spectroscopy together with electron ionization/ESI mass spectrometric techniques and were identified as (2R, 3S) volkensiflavone-7-O-rhamnopyranoside (1), volkensiflavone (2), 4″-O-methyl-volkensiflavone (3), volkensiflavone-7-O-glucopyranoside (4), morelloflavone (5), 3″-O-methyl-morelloflavone (6) and morelloflavone-7-O-glucopyranoside (7). The absolute configuration of compound 1 was assigned by circular dichroism spectroscopy as 2R, 3S. The coexistence of conformers of isolated biflavonoids in solution at 25 °C in different solvents was confirmed by variable temperature NMR studies. At room temperature (25 °C), compounds 1-7 exhibited duplicate NMR signals, while at elevated temperature (90 °C), a single set of signals was obtained. Compound 5 showed significant in vitro antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulfonic acid radicals. The antibacterial studies showed that compounds 5 and 6 are the most active against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds 3 and 6 also showed moderate antituberculosis activity against H38 Rv. Based on the research findings, G. hombroniana could be concluded as a rich source of flavanone-flavone (3 → 8) biflavonoids that exhibit rotameric behaviour at room temperature and display significant antioxidant and antibacterial activities.

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“…Nevertheless, other studies have shown that natural compounds isolated from licorice root ( Glycyrrhiza glabra ) have the ability to inhibit rotavirus infection in vitro used as a pre-treatment [ 26 , 27 ]. However, previous phytochemical studies carried out with A. bogotensis demonstrated the presence of flavonoids [ 28 ] which have been extensively studied by their antiviral properties, including the inhibitory effect on rotavirus infection [ 29 , 30 ]. Qualitative tests carried out in this work aimed to a partial characterization of the active F1 fraction confirmed the presence of flavonoid compounds.…”

Section: Discussionmentioning

confidence: 99%

In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

Tellez¹,

Téllez²,

Velez³

et al. 2015

BMC Complement Altern Med

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BackgroundAchyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus activity.MethodsSeveral extracts and fractions phytochemically obtained from A. bogotensis were evaluated initially for their cell toxicity on MA104 and Caco2 cells and then for their anti-rotavirus (RRV) and anti-astrovirus (Yuc8) activity following three strategies: pre-treatment of cells (blocking effect), direct viral activity (virucidal effect) and post-treatment of infected cells (reduction of viral yield post-infection). In addition qualitative chemical studies were developed for the active compounds.ResultsNon-toxic concentrations of a fraction obtained exhibited antiviral activity against both viruses characterized by a virucidal effect and by the reduction of the infectious particles produced post-infection. Steroids, sterols, terpenes, phenols, flavonoids and sesquiterpenlactones were identified qualitatively in the active fraction.ConclusionsA. bogotensis contains substances with in vitro antiviral activity against rotavirus and astrovirus. This study confirms their anti-microbial properties and describes by the first time its antiviral activity in vitro.

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Evaluation of antirotavirus activity of flavonoids

Cited by 29 publications

References 33 publications

Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA

Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA

Complete NMR assignments of bioactive rotameric (3 → 8) biflavonoids from the bark of Garcinia hombroniana

In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

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