2018
DOI: 10.7717/peerj.5159
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Abstract: BackgroundCassia fistula (L.) (Fabaceae) is a medicinal plant from tropical Asia. It is known for its marked antioxidant activity, which is attributed to its high phenolic content. The present study aims at testing both the antioxidant and neuroprotective effects of a hydroalcoholic extract from the aerial parts of Cassia fistula using the Caenorhabditis elegans model, which is widely used in this context.MethodsChemical profiling of secondary metabolites that seem to be responsible for both antioxidant and ne… Show more

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Cited by 28 publications
(33 citation statements)
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“…The assay was modified as previously described [19, 24]. Age synchronized L1 larvae stage of wildtype N2 and transgenic CF1038 (DAF-16 loss-of-function mutant) worms were divided into four groups of 80 worms each and treated with different concentrations of CM extracts or with DMSO diluted in S-medium and bacteria, as mentioned above.…”
Section: Methodsmentioning
confidence: 99%
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“…The assay was modified as previously described [19, 24]. Age synchronized L1 larvae stage of wildtype N2 and transgenic CF1038 (DAF-16 loss-of-function mutant) worms were divided into four groups of 80 worms each and treated with different concentrations of CM extracts or with DMSO diluted in S-medium and bacteria, as mentioned above.…”
Section: Methodsmentioning
confidence: 99%
“…After that, the worms were mounted on a glass slide and paralyzed by the addition of 10 mM sodium azide, and at least 30 worms were randomly photographed using a fluorescence microscope BIOREVO BZ-9000 with a mercury lamp (Keyence Deutschland GmbH, Neu-Isenburg, Germany) with λex 480/20 nm, λem 510/38 nm, 10X objective lens and constant exposure time. ImageJ software version 1.50i (National Institutes of Health, Bethesda, MD, USA) was then used to measure the relative fluorescence intensity of the full body [19, 24].…”
Section: Methodsmentioning
confidence: 99%
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“…Extracts from Cassia fistula , a tree from tropical Asia, contain mainly phenolic compounds with powerful antioxidant properties [ 134 ]. Treating worms with the extract reduced the number of polyQ inclusion bodies in muscle cells [ 116 ].…”
Section: Oxidative Stress and Huntington Diseasementioning
confidence: 99%