Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug–Shrishadi

Kajaria, Divya; Gangwar, Mayank; Kumar, Dharmendra; Sharma, Amit Kumar; Tilak, Ragini; Nath, Gopal; Tripathi, Yamini Bhusan; Tripathi, Jayant Nath; Tiwari, Shrikant

doi:10.1016/s2221-1691(12)60251-2

Cited by 30 publications

(20 citation statements)

References 16 publications

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“… Amaranthaceae Leaves Pneumonia and asthma Antihistaminic, anti-inflammatory, mast cell stabilizer and bronchoprotective effect. Inhibits action of histamine, acetylcholine and 5-HT [ 139 , 140 ] Albizia lebbeck Benth Moraceae Bark Flu, cough, lung problems Bronchodialator, Anti-allergic, Mast cell stabilizing property due to histamine release and cytokine expression of antigen –ige activated mast cells [ 141 , 142 ] Alstonia scholaris Fabaceae Bark, Leaves Asthma Bronchodialator, anti-tussive effect against sulfur dioxide induced mice coughing and citric acid induced guinea pigs coughing. Anti-asthmatic activity against histamine induced bronchoconstriction [ 143 , 144 ] Althaea officinalis L. Lythraceae Flowers, leaves, roots, fruits Asthma and bronchitis Cough suppressant activity in citric acid-induced cough reflex [ 145 ] Artemisia vulgaris Asclepiadaceae Leaves Asthma Bronchodilator due to anticholinergic and Ca 2+ antagonist mechanisms [ 146 ] Artemisia maritime Asteraceae Aerial parts Cough Bronchodilator activities mediated possibly through dual blockade of calcium channels and phosphodiesterase [ 102 ] Adhatoda vasica Capparidaceae Whole plant Cough, bronchitis, asthma Antiallergic, anti-anaphylact...…”

Section: Resultsmentioning

confidence: 99%

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

et al. 2018

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Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous plant resources to cure various respiratory disorders. The primary objective of this review was to assemble all available ethno-medicinal data of plants used for respiratory disorders in Pakistan. Pharmacological activity of these plants (based upon published scientific research), distribution, diversity, use, preparation methods, economical value, conservation status and various available herbal products of some plants have also been explored. This study scrutinized various electronic databases for the literature on medicinal plants used in Pakistan to treat respiratory disorders. A total of 384 species belonging to 85 families used to treat respiratory disorders in Pakistan has been documented. Cough was the disorder treated by the highest number of species (214) followed by asthma (150), cold (57) and bronchitis (56). Most of the plants belongs to Asteraceae (32) and Solanaceae family (32) followed by moraceae (17), Poaceae (13), and Amaranthaceae (13) with their habit mostly of herb (219) followed by Shrub (112) and tree (69). Traditional healers in the region mostly prepare ethno medicinal recipes from leaves (24%) and roots (11%) in the form of decoction. Among the reported conservation status of 51 plant species, 5 were endangered, 1 critically endangered, 11 vulnerable, 14 rare, 16 least concern, 3 infrequent and 1 near threatened. We found only 53 plants on which pharmacological studies were conducted and 17 plants being used in herbal products available commercially for respiratory disorders. We showed the diversity and importance of medicinal plants used to treat respiratory disorders in the traditional health care system of Pakistan. As such disorders are still causing several deaths each year, it is of the utmost importance to conduct phytochemical and pharmacological studies on the most promising species. It is also crucial to increase access to traditional medicine, especially in rural areas. Threatened species need special attention for traditional herbal medicine to be exploited sustainably.

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Section: Resultsmentioning

confidence: 99%

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

et al. 2018

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“…Experimental and clinical studies showed that it has potent bronchodilator,[10] anti-inflammatory,[11] and anti-anaphylactic[12] effects. It significantly improves the peak expiratory flow rate (PEFR) and forced vital capacity (FVC) in the patients of bronchial asthma.…”

Section: Resultsmentioning

confidence: 99%

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

Kajaria

Ranjana

Tripathi

et al. 2013

J Adv Pharm Technol Res

107

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Asthma and diabetes have strong relationship; both are cause and effect of each other. Oxidative stress due to bronchial asthma may cause insulin resistance whereas lack of proper insulin can cause defective smooth muscle relaxant. There is no single medicine available that can manage both diseases, rather the mainstay treatment of bronchial asthma causes hyperglycemia. Keeping this problem in focus, in this study the hypoglycemic effect of an indigenous antiasthmatic Ayurvedic drug Shirishadi was evaluated. Pancreatic alpha amylase and glucosidase inhibitors offer an effective strategy to lower the level of post prandial hyperglycemia via control of starch breakdown. For evaluation of hypoglycemic activity of drug, in-vitro alpha amylase and alpha glucosidase enzyme inhibition was calculated. Ethanolic extract of compound showed 76.40% + 0.88% reduction in alpha amylase activity and 63.85% + 0.36% in alpha glucosidase activity with IC50 0.68 mg/ml and 2.89 mg/ml, respectively. This study suggests that the ethanolic extract of Shirishadi polyherbal compound effectively acts as alpha amylase and glucosidase inhibitor leading to a reduction in starch hydrolysis and hence acts as antiasthmatic as well as hypoglycemic drug.

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“…In the extracts, total phenols and tannins were found in important concentrations, with greater abundance in the three extracts of ethyl acetate although also were found in lower concentration in the extracts of methanol and hexane. Tannins and phenols have been found in several Solanaceae species, such as S. xanthocarpum, S. nigrum Linn, and S. trilobatum, and its presence has been linked to the medicinal and therapeutic effects in diseases such as anti-ulcerogenic, anti-microbial, bronchodilator, anti-inflammatory, inductor of some human cancer cells apoptosis, and cycle cell arrest (21,(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Assessments of Antioxidant Content and the Anti-Carcinogenic Effect of Extracts of Solanum Rostratum Dunal in Human Cancer Cells

Vega¹,

Izquierdo-Vega²,

Ibarra³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Cancer includes a group of more than 100 different types of diseases characterized by the accelerated and disorderly growth of abnormal cells. Cancer is a major worldwide public health problem. According to the International Agency for Research on Cancer (IARC), cancer increased to 18.1 million new cases and 9.6 million cancer deaths in 2018 (1). Historically, natural products have been used since ancient times and in folklore for treatment of many diseases (2). Traditional medicine is known the sum total of the knowledge, skills, and practices based on the theories and experiences indigenous to different cultures used in the maintenance of health and for the prevention, diagnosis, improvement, and/or treatment of illness (3). Plants have comprised the basis of traditional medicine systems and their use by the peoples of many cultures has been widely documented. The World Health Organization has estimated that approximately 80% of the worldís inhabitants mainly employ traditional medicine for their primary healthcare (4). Currently, the use of medicinal plants to treat and prevent various types of cancer has experienced a breakthrough. Along with the cancer treatment ranging from surgery and radiation to chemotherapy or immunotherapy, millions of people seek additional options such as complementary and alternative medicine. In traditional Mexican folk medicine, Solanum rostratum has been used for years to treat kidney disorders, stomachache, and digestive disorders and with the use of the infusion of the leaves as a purgative. A tea prepared with the plantís flowers is rec

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Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug–Shrishadi

Abstract: The study reveals that the extracts possess antibacterial activity and antifungal activity in a dose dependent manner. This antimicrobial property may be due to presence of several saponins, further studies are highly needed for the drug development.

Cited by 30 publications

References 16 publications

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

In-vitro α amylase and glycosidase inhibitory effect of ethanolic extract of antiasthmatic drug - Shirishadi

Assessments of Antioxidant Content and the Anti-Carcinogenic Effect of Extracts of Solanum Rostratum Dunal in Human Cancer Cells

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