Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Abstract

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5 mg kg−1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.

The Role of Pomelo Peel Extract for Experimentally Induced Wound in Diabetic Rats

“…36 During PPE treatment there was significant reduction of FBG level progress till the end of the study compared to both control groups (p<0.05) whereas comparable to that obtained by treatment with standard plant (Table 3). The two major flavonoids of citrus maxima are naringenin and hesperidin are proven to be hypoglycemic agents and their hypoglycemic activity is mediated by their ability to inhibit intestinal αglycosidase activity which is a key enzyme of carbohydrate digestion located on intestinal cells, thereby delaying the absorption of carbohydrates in diabetic animals (Jung UJ et al 2004, KnuduSen S et al 2011 suggested that hesperidin may have the ability to protect pancreatic Beta cell from STZ actions and restore their ability to secret insulin. 37,38 Published data show wide phytochemical composition and pharmacological action of citrus maxima fruits.…”

Effects of Shaddock (Citrus maxima) Fruit Juice on Glucose Tolerance and Lipid Profile in Type-II Diabetic Rats

“…The peels are rich in pectin which is known to possess blood sugar lowering and cholesterol lowering properties 8 . Sriparna et al,9 demonstrated the antihyperglycemic effect and antioxidant property of C. maxima leaf in streptozotocin induced diabetic rats. Similarly, a previous study 10 has shown that the fruit juice of Shaddock (C.maxima) possess hypoglycemic and hypocholesterolemic activities.…”

Beneficial effect ofCitrus limonpeel aqueous methanol extract on experimentally induced urolithic rats

“…Further, diets rich in citrate contents are commonly prescribed for stone prevention (Agarwal et al, 2011). In addition to that, Citrus fruits and their peels are found to help in improving various metabolic and inflammatory disorders attributing to the abundance in its bioactive compounds (Kundusen et al, 2011;Sood et al, 2010). Hence, this study was designed to investigate the efficacy of LP extract in experimentally induced hyperoxaluric animals.…”