Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice

Bala, Asis; Kar, Biswakanth; Haldar, Pallab Kanti; Mazumder, Upal Kanti; Bera, Subhas Chandra

doi:10.1016/j.jep.2010.03.010

Cited by 106 publications

(71 citation statements)

References 8 publications

(7 reference statements)

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“…Its ability to overcome multidrug resistance in human leukemia and colon carcinoma cell lines was defined. AMR IC 50 values of multidrugresistant leukemia (CEM/VLB) and colon carcinoma (SW620/Ad-300) cell lines were higher (1.9-and 6-fold) than parental sensitive cell lines (CEM and SW620). These fractions were explored for their anticancer potential against two breast cancer (MCF-7 and HTB-126) and three pancreatic cancer (Panc-1, Mia-Paca2, and Capan1) also.…”

Section: Antiaris Africanamentioning

confidence: 93%

“…Essential oil components monocyclic (cymene, limonene, piperitone and thymol) and bicyclic (α-pinene, myrtenol and 1,8-cineole) monoterpenoid and phenylpropanoid (methyleugenol, isoeugenol and elemicin) derived from the methanolic extract of roots and rhizomes of A. californica demonstrated anti-proliferative activity against AN3CA and HeLa cells in vitro. The IC 50 values for the root oil were 0.056% and 0.052% (v/v) for the AN3CA and HeLa cells respectively. The concentration of these oils α-pinene (1.9%), β-phellandrene (1.6%), 1,8-cineole (2.5%), piperitone (11.5%), methyleugenol (6.9%), (E)-caryophyllene (4.6%) and elemicin (53%) have anticancer activity.…”

Section: Anemopsis Californicamentioning

confidence: 95%

“…The isolated flavonoid fraction from the whole plant of Emilia sonchifolia (ES) has possible antitumor activity, compared with quercetin. The inhibitory concentration 50% (IC 50 ) values obtained for superoxide production was 48 μg (Flavonoid fraction of ES) compared to 32 μg for quercetin. Methanolic extract of Emilia sonchifolia was found to be cytotoxic to Daltons lymphoma (DL), Ehrlich ascites carcinoma (EAC) and mouse lung fibroblast (L-929) cells, but not toxic to normal human lymphocytes, under in vitro conditions.…”

Section: Emilia Sonchifoliamentioning

confidence: 99%

“…MECG shows significant decrease in (p<0.01) tumour volume, viable cell count, tumour weight and elevated the life span of EAC tumor bearing mice. 50 …”

Section: Cleome Gynandramentioning

confidence: 99%

“…Exposure of DU145 cells to β-lapachone resulted in growth inhibition and induction of apoptosis in a dosedependent manner. 137,138 Vaccinium macrocarpon Triterpene cinnamates 3-O-p-hydroxycinnamoyl ursolic acid purified from the ethyl acetate extracts of Vaccinium macrosporan (Ericaceae) showed slightly greater activity of compound in most tumor cell lines, with GI 50 values of approximately 20 µM in MCF-7 breast, ME180 cervical and PC3 prostate tumor cell lines. Antiproliferative activities of isolated compounds from cranberries extract against HepG2 human liver cancer and MCF-7 human breast cancer cells were evaluated.…”

Section: Tabebuia Avellanedaementioning

confidence: 99%

See 4 more Smart Citations

Medicinal Plants for Treatment of Cancer: A Brief Review

Jain¹,

Dwivedi²,

Jain³

et al. 2016

phcogj

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Section: Antiaris Africanamentioning

confidence: 93%

Section: Anemopsis Californicamentioning

confidence: 95%

Section: Emilia Sonchifoliamentioning

confidence: 99%

“…MECG shows significant decrease in (p<0.01) tumour volume, viable cell count, tumour weight and elevated the life span of EAC tumor bearing mice. 50 …”

Section: Cleome Gynandramentioning

confidence: 99%

Section: Tabebuia Avellanedaementioning

confidence: 99%

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Medicinal Plants for Treatment of Cancer: A Brief Review

Jain¹,

Dwivedi²,

Jain³

et al. 2016

phcogj

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Developmental and genetic basis of the androgynophore in Gynandropsis gynandra

Zenchyzen,

Carey,

Antochi‐Crihan

et al. 2023

American J of Botany

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Premise Flowering plants have evolved a vast array of floral features involved in plant–pollinator interactions. A feature that seemingly increases the chance of pollen transfer is the androgynophore, a stalk‐like structure that raises the reproductive organs of the flower. However, little is known about the developmental and genetic basis of this structure despite its presence in multiple, distantly related taxa. Here, we address this gap by investigating Gynandropsis gynandra (Cleomaceae), a species with a prominent androgynophore. Methods We combined morphological and anatomical analyses with a comparative transcriptomic study to provide a detailed description of the androgynophore throughout development, examine global gene expression patterns, and identify candidate genes putatively involved in androgynophore elongation. Results The radially symmetric androgynophore of G. gynandra rapidly lengthens primarily via cell elongation. Despite its structural uniformity, androgynophore development is characterized by complex gene expression patterns including differential expression of floral organ identity genes and genes associated with organ development and growth in Arabidopsis thaliana. Conclusions Our morphological characterizations and high‐quality transcriptome for G. gynandra suggest that the androgynophore is a novel structure formed via elaboration of both the receptacle and base of reproductive organs because it is structurally like an elongated internode but expresses the genetic repertoire typically associated with the reproductive organs. The drastic increase in cell length and uniform structure elevates the androgynophore as a potentially powerful model for cell elongation.

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A New Indole Alkaloid from Cleome droserifolia

Hussain

Khan

Ali

et al. 2015

Helvetica Chimica Acta

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The phytochemical investigations on Cleome droserifolia resulted in the isolation and characterization of a new indole alkaloid, 5‐hydroxy‐2‐methoxy‐1‐methyl‐1H‐indole‐3‐carbaldehyde (1). The structure elucidation was carried out on the basis of 1D‐ and 2D‐NMR techniques. In addition to 1, two known aromatic derivatives, veratrol (2) and 2‐methoxy‐4‐methylacetophenone (3), were also obtained. All these compounds were purified by repeated column chromatography of the CH2Cl2 fraction obtained from MeOH extract of Cleome droserifolia. The structure of the new compound 1 was finally confirmed by the combined 1D (1H‐ and 13C‐) and 2D (HC correlations; HMBC and HSQC) NMR and IR spectroscopy, mass spectrometry (MS), and UV absorption spectroscopy techniques. The comparison of the physical and spectroscopic data with those in the literature provided evidence for the structure confirmation of known compounds. All the purified compounds were subjected to urease and α‐glucosidase enzymes inhibition. The results showed that compound 1 was more potent with an IC50 value 11.97±2.067 μg/ml towards urease inhibition, while the activity of α‐glucosidase enzyme was marginal.

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Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice

Cited by 106 publications

References 8 publications

Medicinal Plants for Treatment of Cancer: A Brief Review

Medicinal Plants for Treatment of Cancer: A Brief Review

Developmental and genetic basis of the androgynophore in Gynandropsis gynandra

A New Indole Alkaloid from Cleome droserifolia

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