Evaluation of anti-tubercular activity of linolenic acid and conjugated-linoleic acid as effective inhibitors against Mycobacterium tuberculosis

Choi, Won Hyung

doi:10.1016/j.apjtm.2016.01.021

Cited by 22 publications

(12 citation statements)

References 15 publications

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“…Furthermore, lauric acid (10) exhibited antidiabetic [51] and antibacterial [52] activities. Simultaneously, linoleic acid (16), polyunsaturated fatty acid, presents antimicrobial [53] and anti-inflammatory activities, [54] and is also involved in the synthesis of prostaglandins, thromboxanes and leukotriene. [55] In conclusion, the two studied halophytic grasses seem to be rich in fatty acids, especially in saturated fatty acids.…”

Section: Fatty Acids and Their Ester Derivativesmentioning

confidence: 99%

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Faustino

Silva

et al. 2020

Chemistry & Biodiversity

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Spartina maritima and Puccinellia maritima are two fascinating but underexplored halophytic species, and herein, the chemical profile of their hexane extracts is described. Terpenoids and sterols were the most abundant chemical groups in both species. The second dominant class was alcohols and the third esters of fatty acids. The chemical lipophilic profile of both S. maritima and P. maritima is herein reported for the first time. Through the accomplished data, it is possible to conclude that these species are rich in essential compounds that can be relevant to endorse their use as nutraceuticals. Furthermore, through a principal component analysis, a clear differentiation between the taxa was achieved, which indicates that their response to salinity stress is different. That fact was confirmed by the pathway enrichment analysis, which showed that the induced changes in metabolic pathways vary in each species.

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Section: Fatty Acids and Their Ester Derivativesmentioning

confidence: 99%

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Faustino

Silva

et al. 2020

Chemistry & Biodiversity

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“…[58,59] In addition, Linolenic acid was also present in the extract of Khalas date, a research demonstrated that linoleic acid effectively inhibited Mycobacterium tuberculosis. [60] ).…”

Section: Resultsmentioning

confidence: 99%

Phenolic profiling and antibacterial potential of Saudi Arabian native date palm (Phoenix dactylifera) cultivars

Mediani

2020

International Journal of Food Properties

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Date Palm (Phoenix dactylifera) is one of the important fruit enriched with an impressive list of essential nutrients and a wide range of phenolic compounds with high antibacterial compounds. In order to provide further detailed information on phenolic compounds and antibacterial activities of Date Palm (Phoenix dactylifera), the current study was devoted to investigate and compare three different highly consumable varieties of date palm (Phoenix dactylifera) cultivars, namely Ajwa, Khalas Alkharj, and Al-Qasim for their broad spectrum antibacterial effect and phenolic compounds. The antibacterial properties of their methanolic extracts were evaluated against Streptococcus pnuemoniae, Bacillus subtilis, Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli. All of the three cultivars displayed a broad spectrum of inhibitory effect against these pathogenic bacteria. Moverover, the LC-Linear Ion Quadrupole Mass Spectrometric Analysis (LC-MS and LC-MS/MS Tandem Mass Spectrometry) analysis revealed the presence of 3,30-di-O-methyl ellagic acid, 7-Methoxyquercetin-O-hexose isomers, caffeic acid, ferulic acid, isomers of quercentin-rutinoside, kaempferol methylether, p hydroxybenzoic acid, phytol, punicalagin and quercetin-3-O-glucoside (isoquercitrin) were in Ajwa, 3,30-di-O-methyl ellagic acid isomers, 3,30-di-O-methyl ellagic acid, caffeic acid derivative, cafeic acid, caffeoyl glucose, caffeoylshikimic acid, ferulic acid, guaiacyl(8-5)ferulic acid hexoside isomer, isorhamnetin-3-Ohexoside, oxooctadecanoic acid, punicalagin and quercetin derivativein Al-Qasim extracts while 2(3,4-Dihydroxyphenyl)-7-hydroxy-5-benzene propanoic acid isomer, 2 (3,4-Dihydroxyphenyl)-7-hydroxy-5-benzene propanoic acid, decanoic acid derivative, diosmetin, kaempferol-3-rutinoside, linolenic acid, oxooctadecanoic acid conjugate and punicalagin in the extract of Khalas date. The findings of the current study may increase our knowledge about the importance of dates in diet and can be utilized as natural antimicrobial agents in the foods industry. ARTICLE HISTORY

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“…At the same time, linoleic acid ( 50 ), another polyunsaturated fatty acid, is involved in the synthesis of prostaglandins, thromboxanes and leukotriene, a fact recognized over the last century [76]. Several studies have also reported its antimicrobial [77] and anti-inflammatory activities [78].…”

Section: Phytoconstituents Of Halophytic Grassesmentioning

confidence: 99%

Halophytic Grasses, a New Source of Nutraceuticals? A Review on Their Secondary Metabolites and Biological Activities

Faustino

Pinto

2019

IJMS

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The Poaceae family, known as grasses, is distributed worldwide and is considered the most important group of monocotyledonous crops. Salt stress is multifactorial, therefore to survive, halophytes evolved a variety of adaptations, which include the biosynthesis of different primary and secondary metabolites. This trait enhances the accumulation of important families of compounds crucial to the prevention of a variety of chronic diseases. Besides, if proven edible, these species could cope with the increased soil salinity responsible for the decline of arable land due to their high nutritional/nutraceutical value. Herein, the phytochemical investigations performed in halophytes from the Poaceae family as well as their biological properties were explored. Among the 65 genera and 148 species of known halophytic grasses, only 14% of the taxa were studied phytochemically and 10% were subjected to biological evaluation. Notably, in the studied species, a variety of compound families, as well as bioactivities, were demonstrated, highlighting the potential of halophytic grasses.

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Evaluation of anti-tubercular activity of linolenic acid and conjugated-linoleic acid as effective inhibitors against Mycobacterium tuberculosis

Cited by 22 publications

References 15 publications

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Lipophilic Metabolites of Spartina maritima and Puccinellia maritima Involved in Their Tolerance to Salty Environments

Phenolic profiling and antibacterial potential of Saudi Arabian native date palm (Phoenix dactylifera) cultivars

Halophytic Grasses, a New Source of Nutraceuticals? A Review on Their Secondary Metabolites and Biological Activities

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