Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: Possible involvement of NOS inhibition

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

“…Further, areca nut has antioxidant, anti-inflammatory, and anti-osteoporotic properties [21][22][23]. Overall, the results of the present study are consistent with those of earlier works, in which extracts and compounds isolated from A. catechu were found to have an analgesic effect in mice and rats [6,7] and antimigraine activity in rats [8,9]. Furthermore, the current study demonstrated the antiallodynic effects of intrathecal areca nut in spinal nerve-ligated and cisplatin-induced NP states.…”

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

“…Further, areca nut has antioxidant, anti-inflammatory, and anti-osteoporotic properties [21][22][23]. Overall, the results of the present study are consistent with those of earlier works, in which extracts and compounds isolated from A. catechu were found to have an analgesic effect in mice and rats [6,7] and antimigraine activity in rats [8,9]. Furthermore, the current study demonstrated the antiallodynic effects of intrathecal areca nut in spinal nerve-ligated and cisplatin-induced NP states.…”

Anti-migraine effect of Areca Catechu L. nut extract in bradykinin-induced plasma protein extravasation and vocalization in rats

“…might be through the activation of serotonin 5-HT1B receptors as like sumatriptan and inhibition of release of several vasoactive and sensory neuropeptides like substance P, CGRP, VIP, neurokinin A and of other vasodilator transmitters, such as NO. ANE also inhibits the NO as substantiated by our previous findings in the model of glyceryl trinitrate induced plasma protein extravasation in rat (Bhandare et al, 2011). Overall these findings reinforce the fact that ANE is specifically effective in migraine pain at the dose of 250 and 500 mg/kg orally in rats and could be a future promising therapeutic strategy for prevention of migraine.…”

Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor

“…Activation of b-adrenergic receptor will transmit an inhibitory message to gastric smooth muscle (Mandrek and Kreis, 1992), which suggests that SMD may promote contractions through inhibition of b-adrenergic receptor. Exogenous NO also decreases the SMD-induced contractions, it has been clarified that herb can suppress expression of nitric oxide synthase (Bhandare et al, 2011), which indicates that inhibition of NO releasing may be a way involved in SMD-induced contractions. Even though study shows that excitation of nicotinic receptor will abolish spontaneous contractions of colonic strips (Auli et al, 2008), another study suggests that activation of nicotinic receptor can increase contractile response of rabbit gastric fundus through facilitating release of neurotransmitters (Ilhan et al, 2007), and our results also indicate that the excitation of nicotinic receptor is a way of SMD promoting contractions of antral strips.…”

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

“…Further, areca nut has antioxidant, anti-inflammatory, and anti-osteoporotic properties [21][22][23]. Overall, the results of the present study are consistent with those of earlier works, in which extracts and compounds isolated from A. catechu were found to have an analgesic effect in mice and rats [6,7] and antimigraine activity in rats [8,9]. Furthermore, the current study demonstrated the antiallodynic effects of intrathecal areca nut in spinal nerve-ligated and cisplatin-induced NP states.…”

Anti-migraine effect of Areca Catechu L. nut extract in bradykinin-induced plasma protein extravasation and vocalization in rats

“…might be through the activation of serotonin 5-HT1B receptors as like sumatriptan and inhibition of release of several vasoactive and sensory neuropeptides like substance P, CGRP, VIP, neurokinin A and of other vasodilator transmitters, such as NO. ANE also inhibits the NO as substantiated by our previous findings in the model of glyceryl trinitrate induced plasma protein extravasation in rat (Bhandare et al, 2011). Overall these findings reinforce the fact that ANE is specifically effective in migraine pain at the dose of 250 and 500 mg/kg orally in rats and could be a future promising therapeutic strategy for prevention of migraine.…”

Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor

“…Activation of b-adrenergic receptor will transmit an inhibitory message to gastric smooth muscle (Mandrek and Kreis, 1992), which suggests that SMD may promote contractions through inhibition of b-adrenergic receptor. Exogenous NO also decreases the SMD-induced contractions, it has been clarified that herb can suppress expression of nitric oxide synthase (Bhandare et al, 2011), which indicates that inhibition of NO releasing may be a way involved in SMD-induced contractions. Even though study shows that excitation of nicotinic receptor will abolish spontaneous contractions of colonic strips (Auli et al, 2008), another study suggests that activation of nicotinic receptor can increase contractile response of rabbit gastric fundus through facilitating release of neurotransmitters (Ilhan et al, 2007), and our results also indicate that the excitation of nicotinic receptor is a way of SMD promoting contractions of antral strips.…”

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats

“…Further, areca nut has antioxidant, anti-inflammatory, and anti-osteoporotic properties [21][22][23]. Overall, the results of the present study are consistent with those of earlier works, in which extracts and compounds isolated from A. catechu were found to have an analgesic effect in mice and rats [6,7] and antimigraine activity in rats [8,9]. Furthermore, the current study demonstrated the antiallodynic effects of intrathecal areca nut in spinal nerve-ligated and cisplatin-induced NP states.…”

Anti-migraine effect of Areca Catechu L. nut extract in bradykinin-induced plasma protein extravasation and vocalization in rats

“…might be through the activation of serotonin 5-HT1B receptors as like sumatriptan and inhibition of release of several vasoactive and sensory neuropeptides like substance P, CGRP, VIP, neurokinin A and of other vasodilator transmitters, such as NO. ANE also inhibits the NO as substantiated by our previous findings in the model of glyceryl trinitrate induced plasma protein extravasation in rat (Bhandare et al, 2011). Overall these findings reinforce the fact that ANE is specifically effective in migraine pain at the dose of 250 and 500 mg/kg orally in rats and could be a future promising therapeutic strategy for prevention of migraine.…”

Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor

“…Activation of b-adrenergic receptor will transmit an inhibitory message to gastric smooth muscle (Mandrek and Kreis, 1992), which suggests that SMD may promote contractions through inhibition of b-adrenergic receptor. Exogenous NO also decreases the SMD-induced contractions, it has been clarified that herb can suppress expression of nitric oxide synthase (Bhandare et al, 2011), which indicates that inhibition of NO releasing may be a way involved in SMD-induced contractions. Even though study shows that excitation of nicotinic receptor will abolish spontaneous contractions of colonic strips (Auli et al, 2008), another study suggests that activation of nicotinic receptor can increase contractile response of rabbit gastric fundus through facilitating release of neurotransmitters (Ilhan et al, 2007), and our results also indicate that the excitation of nicotinic receptor is a way of SMD promoting contractions of antral strips.…”