Evaluation of anti-inflammatory activity of Boswellia serrata on carrageenan induced paw edema in albino Wistar rats

Abstract

Boswellia serrata is widely used in Ayurveda from ancient India. It is also referred as Indian Frankincense. 1 From centuries resin derived from it used to treat arthritis associated chronic inflammatory illnesses in Asian and African folk medicine. 2 The texts of Ayurveda and Unani cites that it is used as an effective remedy for treating diarrhoea, dysentery, ringworm, boils, fevers, skin and blood diseases, cardiovascular diseases, mouth sores, bad throat, bronchitis, asthma, cough, vaginal discharges, hair-loss, jaundice, hemorrhoids, syphilitic diseases, irregular menses and liver disorders. It also acts as diaphoretic, astringent, diuretic and acts both as internal and external stimulant. 3,4 Recent studies also states that it has anti-arthritic, anti-inflammatory, anti-hyperlipidemic, anti-atherosclerotic, analgesic and hepato-protective effect. 5 Inflammation is an important physiological reaction which occurs in response to a wide variety of injurious agents such as physical trauma, bacterial infection, ABSTRACT Background: Inflammation is a response of the immune system, guarding the individual against infection. It is a major burning problem worldwide and billions of individuals are affected. Moreover administration of current antiinflammatory drugs is often associated with severe side effects. Hence alternative therapeutic modules are necessitated. Now a day's herbal medicines are using due to their high efficacy and harmless to cure the diseases. In traditional medicine Boswellia serrata (B. serrata) has been widely used to treat various diseases which also include Inflammation. Till now the effect of B serrata on inflammation was not well understood. Hence In the present study we made an attempt to evaluate the anti-inflammatory activity of B. Serrata against carrageenan induced paw edema which is acute model of inflammation. Methods: Albino wistar rats were divided into five groups, group 1 treated with carrageenan (control) whereas group 2, 3, and 4 treated with different doses (50, 100, and 200 mg/kg/bw) of B. serrata along with carrageenan, respectively. Group 5 treated with standard drug (Indomethacin 10 mg/kg/bw). Carrageenan induced paw edema and histopathological study of paw were evaluated in all experimental rats. Results: The present study clearly demonstarted that carrageenan significantly increased paw edema and cellular infiltrates whereas B. serrata treated rats significantly decreased the paw edema and histopathological finding of cellular infiltrates and found to be greater at higher concentration i.e., 200 mg/kg/b/wt as compared to standard drug. Conclusions: The findings from the above study proves that B. serrata has high anti-inflammatory activity and supports its usage in traditional medicine as herbal anti-inflammatory medicine.

Effect of Boswellia serrata extract on acute inflammatory parameters and tumor necrosis factor-α in complete Freund's adjuvant-induced animal model of rheumatoid arthritis

“…Our histopathological observations are also supported by a study in which Boswellia serrata reduces cellular infiltrates in carrageenan-induced inflammation model of RA. [21] Along with other symptoms, decrease in weight also has been observed in RA. This condition has been referred to as rheumatoid cachexia (RC).…”

Analgesic and Anti-Inflammatory Effects of Phaseolus vulgaris L. Fixed Oil in Rodents

“…NSAIDs interfere with prostaglandins production by preventing both COX I and COX II. Pro drugs and modified formulations are being developed to overcome the side effects of NSAIDs [32]. Long term use of conventional analgesics bring about serious side effects which are unpreventable, therefore invention and detection of safe and effective analgesics is necessary [33].…”

Modulation of NRF-2 Pathway Contributes to the Therapeutic Effects of Boswellia serrata Gum Resin Extract in a Model of Experimental Autoimmune Myocarditis

“…To well comprehend which dose of Boswellia extract could be effective, we preliminarily studied the effects of Boswellia extract on paw edema. We established three doses: 10, 50, and 100 mg/kg based on the literature [ 46 ]. CAR injection caused a time-dependent rise in the paw volume compared to the shams.…”