Evaluation of anthralin in the treatment of alopecia areata

Fiedler-Weiss, Virginia C.

doi:10.1001/archderm.123.11.1491

Cited by 37 publications

(35 citation statements)

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“…In a study done by Fiedler-weiss VC et al, 7 the efficacy of anthralin cream in the treatment of severe AA in 68 patients was evaluated. Cosmetic response that is RGS > 3 was seen in 25% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Hogade¹,

Hussain²

2015

jemds

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BACKGROUND:Alopecia areata is one of the common causes of localized hair loss. Alopecia areata can have spontaneous remission or can follow unpredictable course with exacerbation. Due to which it can be a cause of cosmetic concern for the patient. AIM: To know the efficacy of various topical treatment modalities in Alopecia areata. METHODS: 100 patients presenting with alopecia areata to the dermatology outpatient department of Basaveshwar Teaching and General Hospital and Sangameshwar Hospital, Gulbarga, were included in this study. It was conducted as a randomized prospective study for a period of 12 weeks after taking an informed consent from the patient. Patients were randomly distributed into four treatment groups -A, B, C, D. Group. A were treated with 0.05% Betamethasone Dipropionate cream applied twice daily, Group. B were treated with 2% Minoxidil solution applied 1ml twice daily, Group. C was treated with 1.15% Anthralin ointment applied daily for 15 minutes and Group. D were treated with 0.03% Tacrolimus applied twice daily to the affected areas. Alopecia Grading Scale (AGS) was calculated at first visit and 12 weeks. Regrowth Score (RGS) was calculated at 12 weeks. Treatment outcome in different groups were compared using mean AGS at 12 weeks and RGS. RESULTS: Group A patients showed statistically significant clinical improvement when compared to all the other groups. Poorest response was seen in Group D. CONCLUSION: The study concluded that topical 0.05% betamethasone dipropionate is the most effective topical treatment modality in patients with alopecia areata.

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Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Hogade¹,

Hussain²

2015

jemds

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“…Up to now, numerous studies have been conducted on treatment of alopecia areata and many of those researches have compared the efficacy of different topical agents on hair regrowth (14)(15)(16)(17)(18)(19)(20). In a comparative study of topical 0.05% tretinoin, topical betamethasone dipropionate lotion, and 0.25% dithranol paste, satisfaction was reported by 55% of patients who were treated with topical tretinoin in comparison with 70% and 35% of cases who were respectively underwent topical steroid and dithranol therapy (14).…”

Section: Discussionmentioning

confidence: 99%

“…In an open study, cosmetic response was observed in 25% of patients with severe alopecia areata who were treated with 0.5% to 1.0% anthralin cream (16). In another study, the combination of 5% minoxidil and 0.5% anthralin was used to treat 51 patients with severe alopecia areata and only 11% of patients achieved cosmetically acceptable hair regrowth (17).…”

Section: Discussionmentioning

confidence: 99%

Comparing the Efficiency of Elidel Cream and Elidel Accompanied With Tretinoin Cream in Treatment of Alopecia Areata

et al. 2014

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Background: Alopecia areata is a disorder causing local or total body hair loss. Various therapeutic modalities have been used for the treatment of this disease; however, none of them were completely effective. Objectives: In this study, we compared the efficacy of topical Elidel alone and Elidel accompanied with tretinoin in the treatment of alopecia areata. Patients and Methods: This randomized controlled clinical trial was performed on patients with alopecia areata in Rasul-e Akram Hospital in Tehran, Iran, from 2010 to 2011. Patients in the Elidel group applied Elidel 1% cream twice a day. The second group received 1% Elidel in the mornings and 0.05% tretinoin in the evenings. The results compared after three months of treatment. Results: A total of 80 patients were randomly allocated to two treatment groups. The mean age of the patients was 21.8 ± 3.9 and 21.6 ± 4.4 years in the Elidel and Elidel plus tretinoin groups, respectively (P = 0.879). There were 26 males (65%) in the Elidel and 24 (60%) male patients in Elidel plus tretinoin groups (P = 0.481). In The Elidel group, the complete cure was observed in eight patients (20%), relative cure in 14 (35%), no change in 10 (25%), and disease aggravation in 8 (20%) cases; in the Elidel plus tretinoin group, the complete cure was reported in 18 patients (45%), relative cure in 12 (30%), no change in 8 (20%), and disease aggravation in 2 (5%) (P = 0.048) cases. The cure rate in both groups significantly changed in comparison to the previous findings (P < 0.001). Conclusions: Our study showed that the combined use of Elidel and tretinoin was more effective than Elidel alone.

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“…15 Cosmetic response that is RGS >3 was seen in 25% of the patients. Hence, Anthralin was also considered a reasonable therapeutic option for severe AA.…”

Section: Efficacy Of 115% Anthralin Ointmentmentioning

confidence: 99%

A randomized prospective study to evaluate the efficacy of various topical treatment modalities in patients of alopecia areata

Manthale¹,

Raikar

Raikar³

2017

Int J Res Dermatol

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Background:Alopecia areata (AA) is one of the common causes of localized hair loss among the patients attending the outpatient department. The objective of this study was to know the clinical and epidemiological profile of AA and to compare the efficacy of different topical treatment modalities in AA.Methods:100 patients of any age group and of both sexes presenting with AA to the dermatology outpatient department were included in this study. It was conducted as a randomized prospective study for a period of 12 weeks after taking an informed consent from the patient. After studying the clinical profile, patients were randomly distributed, excluding the age and sex bias into four treatment groups. Alopecia grading scale (AGS) was calculated at first visit and 12 weeks. Regrowth score (RGS) was calculated at 12 weeks. Treatment outcome in different groups were compared using mean AGS at 12 weeks and RGS.Results:Group A patients showed statistically significant clinical improvement when compared to all the other groups. Poorest response was seen in Group D. Intermediate response was seen in Group B and C patients.Conclusions:The study concluded that topical 0.05% betamethasone dipropionate is the most effective treatment modality in patients with patchy AA (having <25% hair loss).

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Evaluation of anthralin in the treatment of alopecia areata

Cited by 37 publications

References 0 publications

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Comparison of Efficacy of Various Topical Treatment Modalities in Alopecia Areata

Comparing the Efficiency of Elidel Cream and Elidel Accompanied With Tretinoin Cream in Treatment of Alopecia Areata

A randomized prospective study to evaluate the efficacy of various topical treatment modalities in patients of alopecia areata

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