Evaluation of alpha-glucosidase inhibition activity and glycosides in the Syringa pubescens Turcz from different geographical origin

Wang, Xinsheng; Zhang, Jiameng; Wang, Panxu; Zhang, Yanlong; Yang, Qinyu; Zhang, Zichen; Ma, Zhanqiang; Wu, You; Ma, Jun; Fan, Enguo

doi:10.1016/j.scienta.2023.112198

Cited by 3 publications

(10 citation statements)

References 27 publications

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“…However, the IC 50 values of all tested SPF samples were higher than that of the positive reference (Acarbose, Supplementary Figure S2). These results were compatible with our previous work in that the different original samples possessed α-glucosidase inhibition activities [1]. ROS have been confirmed to be strongly correlated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease [27,28].…”

Section: Enzyme Inhibitory Activitysupporting

confidence: 93%

“…The contents of the bioactive compounds of SPF prepared using five drying methods are shown in Table 1. The data revealed that echinacoisde, forsythoside B, verbascoside and oleuropein (Figure 1) were the major compounds of the SPF extract, which was in agreement with a previous study [1]. Meanwhile, it could be found that the contents of the active ingredients exhibited significant differences under the five drying methods (p < 0.05).…”

Section: The Contents Of Bioactive Compoundssupporting

confidence: 90%

“…Furthermore, our recent study has demonstrated that SPF possessed strong inhibitory activity against α-glucosidase [1]. These biological properties are due to the presence of chemical constituents in SPF.…”

Section: Introductionmentioning

confidence: 96%

“…Syringa pubescens Turcz. (S. pubescens), which is a deciduous shrub, is widely distributed in mountainous areas of the Henan, Shanxi, Shaanxi, Hebei and Shandong Provinces and Beijing City [1]. The dried flower of Syringa pubescens (Syringae Pubescentem Flos, SPF) is often used as a Chinese folk medicine and flower tea for healthcare in the Funiu Mountains in Henan Province.…”

Section: Introductionmentioning

confidence: 99%

“…These biological properties are due to the presence of chemical constituents in SPF. The main compounds in SPF are phenylethanoid glycosides and iridoids [1][2][3]6,7].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Xu,

Zhang,

et al. 2023

Molecules

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The flower of Syringa pubescens Turcz. is used in Chinese folk medicine and also as a flower tea for healthcare. The effects of five drying methods on the active compound contents, the antioxidant abilities, anti-inflammatory properties and enzyme inhibitory activities were evaluated. The plant materials were treated using shade-drying, microwave-drying, sun-drying, infrared-drying and oven-drying. The seven active compounds were simultaneously determined using an HPLC method. Furthermore, the chemical profile was assessed using scanning electron microscopy, ultraviolet spectroscopy and infrared spectroscopy. The antioxidant capacities and protective effects on L02 cells induced with hydrogen peroxide were measured. The anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 cells were investigated. The enzyme inhibitory activities were determined against α-amylase, α-glucosidase cholinesterases and tyrosinase. The results indicated that drying methods had significant influences on the active compound contents and biological properties. Compared with other samples, the OD samples possessed low IC50 values with 0.118 ± 0.004 mg/mL for DPPH radical, 1.538 ± 0.0972 for hydroxyl radical and 0.886 ± 0.199 mg/mL for superoxide radical, while the SHD samples had stronger reducing power compared with other samples. The SHD samples could be effective against H2O2-induced injury on L02 cells by the promoting of T-AOC, GSH-PX, SOD and CAT activities and the reducing of MDA content compared with other samples. Furthermore, SPF samples, especially the SHD sample, could evidently ameliorate inflammation through the inhibition of IL-6, IL-1β and TNF-α expression. All the studied SPF samples exhibited evidently inhibitory effects on the four enzymes. The IC50 values of inhibitory activity on α-glucosidase and α-amylase from SHD sample were 2.516 ± 0.024 and 0.734 ± 0.034 mg/mL, respectively. SD samples had potential inhibitory effects on cholinesterases and tyrosinase with IC50 values of 3.443 ± 0.060 and 1.732 ± 0.058 mg/mL. In consideration of active compound contents and biological activities, it was recommended that SHD and SD be applied for drying SPF at an industrial scale.

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Section: Enzyme Inhibitory Activitysupporting

confidence: 93%

Section: The Contents Of Bioactive Compoundssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

“…These biological properties are due to the presence of chemical constituents in SPF. The main compounds in SPF are phenylethanoid glycosides and iridoids [1][2][3]6,7].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Xu,

Zhang,

et al. 2023

Molecules

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The antioxidant, anti-inflammatory and analgesic activity effect of ethyl acetate extract from the flowers of Syringa pubescens Turcz

Zhang,

Wu,

Wang

et al. 2024

Journal of Ethnopharmacology

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Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flower from <em>Syringa pubescens</em> Turcz

Xu,

Wu,

Zhang

et al. 2023

Preprint

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The flower of Syringa pubescens Turcz. is a Chinese folk medicine and also used as flower tea for healthcare. The effects of five drying methods on the active compound contents, the antioxidant abilities, anti-inflammatory properties and enzyme inhibitory activities were evaluated. The plant materials were treated using shade-drying, microwave drying, sun-drying, infrared drying and oven drying. The seven active compounds were simultaneously determined by an HPLC method. Furthermore, the chemicals differences were assessed using Scanning electron microscopy, UV spectroscopy and infrared spectroscopy. The antioxidant capacities and protective effects on L02 cells induced by hydrogen peroxide were measured. The anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 cells were investigated. The enzyme inhibitory activities were determined against α-amylase, α-glucosidase cholinesterases and tyrosinase. The results indicated that drying methods had significantly influences on the active compound contents and biological properties. In consideration of the contents of bioactive compound, the suitable drying methods were SHD, SD, OD and MD. The SHD sample exhibited stronger radical scavenging ability on DPPH, ABTS, hydroxyl and superoxide anions and higher reducing power compared with other samples prepared by SD, OD, MD and IRD. Moreover, SHD sample had strong protective effects against L02 cells damage induced by H2O2. SPF samples, especially SHD sample, significantly inhibited inflammatory factor secretion in LPS-stimulated RAW 264.7 cell. All studied SPF sample exhibited evidently inhibitory effects on the four enzymes. SHD sample possessed the highest inhibitory activity on α-glucosidase and α-amylase. While SHD and SD samples had the potential inhibitory effects on cholinesterases and tyrosinase. In consideration of active compound contents and biological activities, it was recommended that SHD and SD were applied for drying SPF at an industrial scale.

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Evaluation of alpha-glucosidase inhibition activity and glycosides in the Syringa pubescens Turcz from different geographical origin

Cited by 3 publications

References 27 publications

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flowers from Syringa pubescens Turcz

The antioxidant, anti-inflammatory and analgesic activity effect of ethyl acetate extract from the flowers of Syringa pubescens Turcz

Influence of Five Drying Methods on Active Compound Contents and Bioactivities of Fresh Flower from <em>Syringa pubescens</em> Turcz

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