Evaluation of acute skin toxicity of breast radiotherapy using thermography: Results of a prospective single-centre trial

Maillot, O.; Leduc, Nicolas; Atallah, V.; Escarmant, Patrick; Petit, A.; Belhomme, S.; Sargos, P.; Vinh-Hung, Vincent

doi:10.1016/j.canrad.2017.10.007

Cited by 28 publications

(30 citation statements)

References 17 publications

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“…Figure 2 shows that the highest temperature increase was achieved in the third week of the treatment, which is consistent with the literature [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. The temperature rise is seen at the Planned Target Volume (PTV) at which the patient dose was the highest.…”

Section: Resultssupporting

confidence: 90%

Correlation between Isotherms and Isodoses in Breast Cancer Radiotherapy—First Study

Plaza

Baic

Lange

et al. 2021

IJERPH

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The study is focused on correlation of isotherms derived from thermal images with an isodoses describing treatment plan for patients with breast cancer treated by radiotherapy. The irradiated area covered the part of the body after mastectomy. The study included patients diagnosed with breast cancer who were qualified for radiotherapy treatment. All patients were monitored during each treatment week during the entire radiotherapy process. The measurements were made under strictly defined conditions. In the treatment planning system (TPS), the specific plan was created for each patient. Spatial dose distribution in the patient’s body was obtained and presented by the isodoses (lines connecting points with the same dose values). The following areas from the treatment planning system were plotted on the thermograms: target (tumor area) and isodose: 45 Gy, 40 Gy, 30 Gy, 20 Gy and 10 Gy. The obtained results indicated a high correlation between magnitude of the dose represented as the isodose and the temperature of the treated skin. Moreover, preliminary analysis showed a repeatable increase of the mean temperature in the irradiated area during the treatment.

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Section: Resultssupporting

confidence: 90%

Correlation between Isotherms and Isodoses in Breast Cancer Radiotherapy—First Study

Plaza

Baic

Lange

et al. 2021

IJERPH

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“…The DST has also been observed between the irradiated breast or the chest wall and the contralateral region in a published article [22], and DST average of more than 1.4 C at 20% of total radiation dose is meaningful for predicting skin reactions. Some results from that study and ours seem to be contradictory, but there are differences in terms of the choice of surgical approach, total radiation dose and the tested radiation field in patients between them.…”

Section: Discussionmentioning

confidence: 92%

Relationships between the changes of skin temperature and radiation skin injury

Zhu

Chen

et al. 2019

International Journal of Hyperthermia

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Background: Radiation skin injury (RSI) causes changes in skin temperature, but detailed information on the thermographic responses is currently lacking. We investigated thermographic patterns after radiotherapy. We hypothesized that skin temperature may be used as a diagnostic and early predictor of RSI severity. Method: All breast cancer patients received radiotherapy after unilateral postmastectomy. The contralateral supraclavicular area served as control, and the frontal thermal image of torso was taken by a thermal infrared imager weekly. We defined areas of interest on bilateral symmetrical supraclavicular area, and analyzed the difference of average and maximum skin temperature (DST average and DST max ) between them. The extent of the weekly variation in DST (DSTW) was calculated using a mathematical formula to represent a trend of skin temperature change. RSI and symptoms related to RSI were scored from baseline to 2 weeks after the end of radiotherapy. Results: Forty-one patients were enrolled in this study. In comparison to the baseline, the DST average and DST max increased significantly over time during radiotherapy (p < .05). The onset of DST increase was accompanied by the onset of radiation dermatitis, and the maximal DST also appeared at the peak of Radiation Therapy Oncology Group (RTOG) and symptom scores. Radiation dose, DST average , burning-feeling and pulling were the independent variables affecting RTOG score according to multivariate analysis (p < .001, p< .034, p< .001, p< .001). Patients with DSTW average >1.223 or DSTW max >1.114 in second week showed a late higher dermatitis score (RTOG score !2). Conclusion: This study confirmed that RSI was associated with thermographic response. Our results suggested that the follow-up observations of skin temperature during radiotherapy could provide the objective evaluation criteria and prediction methods for RSI. ARTICLE HISTORY

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“…Thermal Imaging of Skin Toxicity ROB-D-19-00982 , V3: Dec 11 2019 6 Quantitative thermal imaging has previously been used to identify temperature changes associated with alterations in blood flow and disease presentation (10)(11)(12). Within the RT setting, Maillot et al, investigated the use of thermography to quantitatively evaluate skin toxicity and found that patients that were classified using the CTCAE, and Radiotherapy Oncology Group (RTOG) criteria, demonstrated a high grade of skin toxicity (≥2) that was also associated with an increase in the average local temperature (p<0.05) (13). Furthermore, Maillot, et al found that thermography-derived temperature features recorded a week before the clinical presentation of skin toxicity, had a predictive value of 70%.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Thermal Imaging Biomarkers to Detect Acute Skin Toxicity From Breast Radiation Therapy Using Supervised Machine Learning

Saednia

Tabbarah

Lagree

et al. 2020

International Journal of Radiation Oncology*Biology*Physics

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Radiation-induced dermatitis is a common side effect of breast radiotherapy (RT).Current methods to evaluate breast skin toxicity include clinical examination, visual inspection, and patient-reported symptoms. Physiological changes associated with radiation-induced dermatitis, such as inflammation, may also increase body-surface temperature which can be detected by thermal imaging. Quantitative thermal imaging markers were identified using supervised machine-learning to develop a predictive model for radiation dermatitis.Methods: Ninety patients treated for adjuvant whole-breast radiotherapy (4250 Gy/f x =16) were recruited to the study. Thermal images of the treated breast were taken at four intervals: prior to RT, then weekly, at f x =5, f x =10, and f x =15. Parametric thermograms were analyzed and yielded 26 thermal-based features which included surface temperature (C) and texture parameters

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Evaluation of acute skin toxicity of breast radiotherapy using thermography: Results of a prospective single-centre trial

Cited by 28 publications

References 17 publications

Correlation between Isotherms and Isodoses in Breast Cancer Radiotherapy—First Study

Correlation between Isotherms and Isodoses in Breast Cancer Radiotherapy—First Study

Relationships between the changes of skin temperature and radiation skin injury

Quantitative Thermal Imaging Biomarkers to Detect Acute Skin Toxicity From Breast Radiation Therapy Using Supervised Machine Learning

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