Evaluation of Acute and Chronic Antidiabetic Activity of Ivy (Hedera helix L.) Aqueous Leaf Extract in Rat Model

Khan, Saira; Adil, Anum; Naeem, Sadaf; Jaffar, Nazish; Khatoon, Humera; Ansar, Humera; Shafiq, Yousra

doi:10.3923/pjbs.2020.1357.1368

Cited by 4 publications

(8 citation statements)

References 27 publications

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“…Among these, fat browning has been recognized as a promising strategy to overcome obesity, which increases energy expenditure by transforming WAT to resemble BAT [4]. Previous studies have demonstrated that H. helix has bioactive effects, such as anti-in ammatory, antioxidant, anticancer, and antidiabetic effects [24][25][26][27][28][29]. Considering that these diseases are closely related to obesity, it highlights a reason to explore the effect of H. helix on obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Today, it has become more standardized, and the ingredients extracted from the plant are used to manufacture various types of medicines, such as syrups, suppositories, and eye drops [23]. In addition, through several studies, H. helix has been con rmed to have various bioactivities, including antiin ammatory and analgesic, antimicrobial, antioxidant, anticancer, and antidiabetic effects, in addition to its effects on respiratory diseases [24][25][26][27][28][29]. Furthermore, a triterpene compound found in H. helix is hederagenin (HDG) (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Hederagenin from Hedera helix promotes fat browning in 3T3-L1 adipocytes

Choi,

Lee,

Lim

et al. 2024

Preprint

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Background Currently, the regulation of energy homeostasis through increased energy consumption is attracting attention to treat obesity. White adipose tissue is known to play a role in accumulating energy by storing excess energy, while brown adipose tissue consumes energy and maintains body temperature. Thus, the browning of white adipose tissue has been confirmed to be effective in controlling obesity. Hedera helix (H. helix) has been widely used as a traditional medicine for various diseases. In several previous studies, hederagenin (HDG) from H. helix has demonstrated many biological activities. In this study, we investigated the anti-obesity effect of HDG on fat browning in 3T3-L1 adipocytes. Methods Cytotoxicity was assessed in 3T3-L1 cells through the Dimethyl sulfoxide and thiazolyl blue tetrazolium bromide (MTT) assay, while the extent of lipid accumulation was compared using the Oil red O (ORO) assay. Protein expression and mRNA expression were compared using Western blot and quantitative real-time polymerase chain reaction (qRT-PCR). Results Consequent to HDG treatment, a reduction in lipid accumulation was confirmed through oil red O staining. In addition, this study confirmed that HDG increases heat production by upregulating the expression of several targets related to thermogenesis, including uncoupling protein 1 (UCP1). This process is closely related to the inhibition of lipogenesis through the adenosine monophosphate-activated protein kinase (AMPK) phosphorylation signaling pathway and lipolysis through the protein kinase A (PKA) signaling pathway. Conclusions HDG is expected to be effective in promoting fat browning, indicating its potential as a natural anti-obesity candidate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hederagenin from Hedera helix promotes fat browning in 3T3-L1 adipocytes

Choi,

Lee,

Lim

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Evidências científicas sobre H. helix demostram que, dentro de seu metabolismo secundário complexo, as saponinas se destacam no que diz respeito às propriedades biológicas exercicas pela erva (Al-Snafi et al, 2018Barnes et al, 2020. O efeito antitussígeno da H. helix é especialmente atribuído à α-hederina, a qual age sobre os receptores β2 e tem a capacidade de ocasionar broncodilatação (Song et al, 2015;Khan et al, 2020). Ademais, a mesma substância foi apontada, em outros trabalhos, como antioxidante, anti-inflamatória e antibacteriana (Pop et al, 2017;Khan et al, 2020;AkhlaghI et al, 2022).…”

Section: Introductionunclassified

“…O efeito antitussígeno da H. helix é especialmente atribuído à α-hederina, a qual age sobre os receptores β2 e tem a capacidade de ocasionar broncodilatação (Song et al, 2015;Khan et al, 2020). Ademais, a mesma substância foi apontada, em outros trabalhos, como antioxidante, anti-inflamatória e antibacteriana (Pop et al, 2017;Khan et al, 2020;AkhlaghI et al, 2022). Adicionalmente, o hederacosídeo-c, apresenta ação antitumoral, antioxidante e antibacteriano (Akhlaghi et al, 2022).…”

Section: Introductionunclassified

“…Quanto aos flavonoides presentes na espécie, como a rutina, sugere-se que haja relação com a analgesia, enquanto especificamente à quercetina e à isoquercetina são atribuídos os efeitos hipoglicemiantes, junto com a presença de hederagenina e alguns elementos-traço (Crômio, Manganês e Zinco) (Hong et al, 2015;Song et al, 2015;Dehghan et al, 2020;Khan et al 2020).…”

Section: Introductionunclassified

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Hedera helix L.: uma revisão dos recentes estudos de suas propriedades farmacológicas

Menezes,

Magalhães,

Andrade

et al. 2023

Revista JRG

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Objetivo: Buscar na literatura quais evidências científicas recentes corroboram para as propriedades farmacológicas da H. helix L. Método: Trata-se de uma revisão integrativa da literatura. Foram realizadas buscas nas bases de dados eletrônicas: Biblioteca Virtual em Saúde (BVS), EMBASE e SciVerse Scopus. O intervalo temporal escolhido abrangeu de 2013 a 2023. Resultados: Um total de 40 artigos foram encontrados na base de dados BVS, 27 na Scopus e 8 na Embase. Diante dos critérios de inclusão e exclusão, que responderam à questão norteadora, foram selecionados 13 artigos para análise integral. O uso do extrato da H. helix, como medicamento fitoterápico, é reconhecido pela Agência Nacional de Vigilância Sanitária (ANVISA) pela RE Nº 4.287, de 23 de setembro de 2011, e este uso terapêutico como agente expectorante e antitussígeno é validado cientificamente por publicações científicas. Dentre as atividades farmacológicas comprovadas, destacam-se: expectorante, antitussígena, anticancerígena, anti-inflamatória, antioxidante, antiangiogênicas, neuroprotetora e antiúlcera preventivo. Considerações finais: Diante da importância terapêutica da H. helix como uma planta medicinal promissora com ampla gama de atividades farmacológicas, podendo ser utilizada em diversas aplicações médicas devido à sua eficácia e segurança.

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Anti-inflammatory, Antioxidant, and Wound-healing Properties of the Methanolic Extracts from Hedera helix Fruits and Leaves

Al-jaafreh

2024

Biomed. Pharmacol. J.

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Common Ivy (Hedera helix L.) is an ornamental plant that is known for its aesthetic qualities and ability to provide natural greenery. It is also associated with potential health benefits. When evaluating the phytochemical constituents of H. helix methanolic extracts, the fruit extract had the highest levels of total phenolic compounds (TPC) at 100 GAE mg/g extract, compared to 89.47 GAE mg/g in the leaves extract. In contrast, total flavonoid compounds and total tannin were higher in leaves extracts, 37.14 TE mg/g extract and 24.79 GAE mg/g extract respectively. fruit extracts showed the greatest level of antioxidant properties in the FRAP test 75.5 and 62.35 AscE mg/g extract also in DPPH tests, the IC50 were 3.49 and 8.79 mg/ml for fruit and leaves respectively, demonstrating their potent capacity to neutralize free radicals and high reducing power. However, when evaluated by the ABTS method, the leaves extracts indicated the strongest antioxidant activity, suggesting their potent capacity to neutralize free radicals, the IC50 were 4.54 and 8.69 mg/ml for fruit and leaves respectively, the extracts' inhibitory effects on albumin denaturation were also assessed. The findings demonstrated the potential of the extracts as anti-inflammatory, with the leaf extract having the lowest IC50 values in these tests 75.26± 3.87 µg/ml and 115.62± 56.47 µg/ml, for ripe fruit extract. Furthermore, the lowest contraction value was 81.12% for pure ointment alone, followed by drug ointment and fruit ointment at 86.43 %and 90.21%, respectively, and the extract had the highest contraction rate at 95.82%, which demonstrated the strongest wound healing activity.

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Evaluation of Acute and Chronic Antidiabetic Activity of Ivy (Hedera helix L.) Aqueous Leaf Extract in Rat Model

Cited by 4 publications

References 27 publications

Hederagenin from Hedera helix promotes fat browning in 3T3-L1 adipocytes

Hederagenin from Hedera helix promotes fat browning in 3T3-L1 adipocytes

Hedera helix L.: uma revisão dos recentes estudos de suas propriedades farmacológicas

Anti-inflammatory, Antioxidant, and Wound-healing Properties of the Methanolic Extracts from Hedera helix Fruits and Leaves

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