Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery

Singh, Akhilesh Vikram; Nath, Lila Kanta

doi:10.1016/j.ijbiomac.2011.12.011

Cited by 40 publications

(18 citation statements)

References 11 publications

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“…It has adequate hydration capacity, good rheological properties, low gelatinization temperature, high viscosity stability, anti‐syneresis, and adequate paste clarity . Acetylated starch can be used in food thickening , paper making , and drug delivery . In the textile industry, acetylated starch is used as a sizing agent for polyester/cotton blended yarn because of its affinity to natural and synthetic fibers, adequate water‐solubility and film‐forming ability, and good desizability and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐assisted synthesis and characterization of acetylated corn starch

Zhang

Wang

et al. 2013

Starch Stärke

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In this study, native corn starch (NCS) was acetylated by a microwave‐assisted method using vinyl acetate as an acetylating agent and potassium carbonate as a catalyst. Acetylated corn starch (ACS) was characterized by Fourier‐transform infrared spectroscopy, SEM, and XRD. The optimum conditions of acetylation (i.e., reaction temperature, exposure time, and catalyst concentration) were assessed. The physicochemical properties of ACS including swelling power, solubility, intrinsic viscosity, apparent viscosity, paste clarity, and syneresis were studied. Furthermore, the adhesion property and sizing performance were evaluated. The results revealed that the physicochemical properties of ACS were improved compared with those of NCS. The adhesion force of ACS to polyester/cotton fibers increased significantly; the sizing properties of ACS were better than those of NCS. ACS, which has potential applications in the textile industry, is an ideal substitute for polyvinyl alcohol.

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Section: Introductionmentioning

confidence: 99%

Microwave‐assisted synthesis and characterization of acetylated corn starch

Zhang

Wang

et al. 2013

Starch Stärke

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“…Acetylated moth bean starch (AMBS) Lamivudine [81] In vitro, Evaluation of controlled release of drug in stomach of white albino rabbits.…”

Section: Tabletsmentioning

confidence: 99%

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

et al. 2016

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Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript.

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“…DS and acetyl content (%) of the starch acetate were determined using the method described by Singh and Nath [8]. Accurately weighed 1.0 g sample of native (blank) and ground starch acetate was added to the 75% (v/v) ethanolic solution.…”

Section: Determination Of Degree Of Substitutionmentioning

confidence: 99%