Evaluation of a single-shot gonadotropin-releasing hormone (GnRH) immunocontraceptive vaccine in captive badgers

Cowan, David P.; Smith, Graham C.; Gomm, Matt; Brash, Matt; Bellamy, Fiona; Massei, Giovanna; Conwell, Rachael; Vial, Flavie

doi:10.1007/s10344-019-1296-0

Cited by 8 publications

(8 citation statements)

References 57 publications

(59 reference statements)

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“…Improvest® has been used effectively worldwide for decades now [54]. The similarity is also seen in reduced testicular weight, reduced seminiferous tubule diameter, reduced reproduction, and having little to no effect on body weight compared to the controls seen in our data and the Improvest® literature [55,56,57,58,59]. It is important to remember that the Improvest® label claim states that it suppresses testicular function with no indication for inducing infertility in swine, and it has no indications for mice [11].…”

Section: Discussionmentioning

confidence: 51%

Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine

Waldrop

Smith

Boyle

et al. 2021

Heliyon

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Population and health management of wildlife is a key to environmental health, domestic herd health, and ultimately public health. Many different methods including: surgical sterilization, poison baits, and sponsored hunting programs have been used in the attempt to control populations of various nuisance animal species. Particular interest has been given to immunocontraception through wildlife vaccination protocols. This study specifically looked at the potential immunocontraceptive and protective properties of a Brucella abortus RB51 ΔleuB vaccine expressing Salmonella typhimurium FliC conjugated to porcine follicle stimulating hormone beta subunit (FSHβ) or gonadotropin releasing hormone (GnRH) DNA sequences. B. abortus RB51 ΔleuB pNS4-TrcD-FliC-FSH β (RB51LFSHβ) and B. abortus RB51 ΔleuB pNS4-TrcD-FliC-GnRH (RB51LGnRH) were tested in a pilot breeding study with BALB/c mice, and a significant reduction in fertility characteristics was observed in both male and female mice. Ultimately, this study provides support to test these vaccine candidates in feral swine, a destructive invasive species in the United States of America.

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Section: Discussionmentioning

confidence: 51%

Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine

Waldrop

Smith

Boyle

et al. 2021

Heliyon

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“…The current analysis and other work strongly suggest that reducing infection from the badger population reduces TB incidence rate in local cattle. Similar effects may be achieved or maintained by other measures, such as badger vaccination [36,37] ,…”

Section: Tablementioning

confidence: 75%

Difference in Differences analysis evaluates the effects of the Badger Control Policy on Bovine Tuberculosis in England

Birch,

Bakrania,

Prosser

et al. 2023

Preprint

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Persistent tuberculosis (TB) in cattle populations in England has been associated with an exchange of infection with badgers (Meles meles). A badger control policy (BCP) commenced in 2013. Its aim was to decrease TB in cattle by reducing the badger population available to provide a wildlife reservoir for bovine TB. Monitoring data from 52 BCP intervention areas 200-1600 km2 in size, starting over several years, were used to estimate the change in TB incidence rate in cattle herds, which was associated with time since the start of the BCP in each area. A Difference in Differences analysis addressed the non-random selection and starting sequence of the areas. Herd incidence rate of TB reduced by 56% (95% Confidence Interval 43-67%) up to the fourth year of BCP interventions, with the largest reductions in the second and third years. There was insufficient evidence to judge whether incidence rate reduced further beyond four years. These estimates are the most precise for the timing of decline in cattle TB associated with interventions primarily targeting badgers. They are within the range of previous estimates from England and Ireland. This analysis indicates the importance of reducing transmission from badgers to reduce the incidence of TB in cattle, noting that vaccination of badgers, fertility control and on farm biosecurity may also achieve this effect.

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“…Additionally we assumed a strategy was possible in which all animals trapped annually for vaccination were also given a fertility control agent which stopped them from breeding for life [e.g. 17 ].…”

Section: Methodsmentioning

confidence: 99%

Simulating the next steps in badger control for bovine tuberculosis in England

Smith

Budgey

2021

PLoS ONE

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Industry-led culling of badgers has occurred in England to reduce the incidence of bovine tuberculosis in cattle for a number of years. Badger vaccination is also possible, and a move away from culling was “highly desirable” in a recent report to the UK government. Here we used an established simulation model to examine badger control option in a post-cull environment in England. These options included no control, various intermittent culling, badger vaccination and use of a vaccine combined with fertility control. The initial simulated cull led to a dramatic reduction in the number of infected badgers present, which increased slowly if there was no further badger management. All three approaches led to a further reduction in the number of infected badgers, with little to choose between the strategies. We do note that of the management strategies only vaccination on its own leads to a recovery of the badger population, but also an increase in the number of badgers that need to be vaccinated. We conclude that vaccination post-cull, appears to be particularly effective, compared to vaccination when the host population is at carrying capacity.

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Evaluation of a single-shot gonadotropin-releasing hormone (GnRH) immunocontraceptive vaccine in captive badgers

Cited by 8 publications

References 57 publications

Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine

Brucella abortus RB51 ΔleuB expressing Salmonella FliC conjugated gonadotropins reduces mouse fetal numbers: A possible feral swine brucellosis immunocontraceptive vaccine

Difference in Differences analysis evaluates the effects of the Badger Control Policy on Bovine Tuberculosis in England

Simulating the next steps in badger control for bovine tuberculosis in England

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