Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.018 View full text
Szabolcs Fekete, Róbert Berky, Jenő Fekete, Jean-Luc Veuthey, Davy Guillarme

Abstract: The separation of large biomolecules such as proteins or monoclonal antibodies (mAbs) by RPLC can be drastically enhanced thanks to the use of columns packed with wide-pore porous sub-2 μm particles or shell particles. In this context, a new wide-pore core-shell material has been recently released under the trademark Aeris WIDEPORE. It is made of a 3.2 μm solid inner core surrounded by a 0.2 μm porous layer (total particle size of 3.6 μm). The aim of this study was to evaluate the performance of this new mater…

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