Evaluation of a new copper(II)–curcumin complex as superoxide dismutase mimic and its free radical reactions

Barik, Atanu; Mishra, Beena; Shen, Liang; Mohan, Hari; Kadam, R.M.; Dutta, S.; Zhang, Hongyu; Priyadarsini, K. Indira

doi:10.1016/j.freeradbiomed.2005.05.005

Cited by 205 publications

(142 citation statements)

References 55 publications

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“…The β-diketone component is also capable of chelating copper ions. 19 The mechanism of action of curcumin in inhibiting tau aggregates has not been correlated with its structure; one possibility is that it works via copper ion chelation. 20 Despite its broad spectrum bioactivity, curcumin by itself is a poor therapeutic agent for AD.…”

mentioning

confidence: 99%

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

Dolai¹,

Shi

Corbo³

et al. 2011

ACS Chem. Neurosci.

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The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar−curcumin conjugate inhibits Aβ and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.

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mentioning

confidence: 99%

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

Dolai¹,

Shi

Corbo³

et al. 2011

ACS Chem. Neurosci.

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“…Since GSH is utilized for detoxification of free radicals, increased sensitivity to oxidative stress also occurs when cells are depleted of GSH (Chen et al, 1997;Kaur and Meena, 2012;Sehgal et al, 2012). Curcumin has been found to show promising increase in superoxide dismutase activity with comparable free radical scavenging ability and an improved antioxidant efficacy (Barik et al, 2005;Girish and Pradhan, 2012;Kaur and Meena, 2012;Sehgal et al, 2012). Curcumin thus is a potent dietary antioxidant against ROS and ROS induced cellular damage (Singh and Giri, 2012).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Protects Metronidazole and X-ray Induced Cytotoxicity and Oxidative Stress in Male Germ Cells in Mice

2013

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Metronidazole (MTZ) is a common antiparasitic and antibacterial drug. The drug and X-ray induced effects in mouse sperm count, sperm head abnormality and some oxidative stress parameters have been studied. Simultaneously the protective role of curcumin has been evaluated. MTZ, 40 mg/kg bw and 13.4 mg/kg bw × 3 days exposure induced abnormal sperm head and reduced total sperm count in Swiss albino mice both after 24 h and 35 days of exposure. However, MTZ treatment in mice receiving X-ray irradiation (0.5 Gy) did not changed the incidence of abnormal sperm population or decrease in the total sperm count. Hepatic glutathione (GSH), superoxide dismutase (SOD) declined significantly during the treatment phase with significant rise in lipid peroxidation of the tissue. The cellular changes were estimated by using lipid peroxidative indices like thiobarbituric acid reactive substances (TBARS). Elevated TBARS is indicative of oxidative stress in treated mice. Furthermore, curcumin pre-treatment apparently reduced the frequency of sperm head abnormality and TBARS induced by MTZ alone or in combination with X-ray and increased the levels of hepatic GSH and SOD. The additive effects of MTZ and X-ray could not be observed with regards to sperm head abnormality and total sperm count in the tested dose range although the cellular antioxidants were found to be significantly lowered and lipid peroxidantion increased. The possible role of MTZ and X-ray inducing sperm abnormality, decreased sperm count and alteration in GSH, SOD and TBARS and defensive role of curcumin have been evaluated.

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“…Barik et al [107] have studied the mononuclear copper complex of Curcumin (147) for its superoxide dismutase (SOD) activity. It was found that the copper atom was coordinated through the oxygen donor atoms of Curcumin along with an acetate anion and one water molecule.…”

Section: Metalmentioning

confidence: 99%

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

Vyas¹,

Dandawate²,

Padhyé³

et al. 2013

Current Pharmaceutical Design

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Curcumin is the active component of dried rhizome of Curcuma longa, a perennial herb belonging to ginger family, cultivated extensively in south and southeastern tropical Asia. It is widely consumed in the Indian subcontinent, south Asia and Japan in traditional food recipes. Extensive research over last few decades has shown that curcumin is a potent anti-inflammatory agent with powerful therapeutic potential against a variety of cancers. It suppresses proliferation and metastasis of human tumors through regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases and other enzymes. It induces apoptotic cell death and also inhibits proliferation of cancer cells by cell cycle arrest. Pharmacokinetic data has shown that curcumin undergoes rapid metabolism leading to glucuronidation and sulfation in the liver and excretion in the feces, which accounts for its poor systemic bioavailability. The compound has, therefore, been formulated and administered using different drug delivery systems such as liposomes, micelles, polysaccharides, phospholipid complexes and nanoparticles that can overcome the limitation of bioavailability to some extent. Attempts to avoid rapid metabolism of curcumin until now have been met with limited success. This has prompted researchers to look for new synthetic curcumin analogs in order to overcome the drawbacks of limited bioavailability and rapid metabolism, and gain efficacy with reduced toxicity. In this review we provide a summarized account of novel synthetic curcumin formulations and analogs, and the recent progress in the field of cancer prevention and treatment.

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Evaluation of a new copper(II)–curcumin complex as superoxide dismutase mimic and its free radical reactions

Cited by 205 publications

References 55 publications

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

Curcumin Protects Metronidazole and X-ray Induced Cytotoxicity and Oxidative Stress in Male Germ Cells in Mice

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

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