Evaluation and Comparison of the Effects of Artesunate, Dexamethasone, and Tacrolimus on Sciatic Nerve Regeneration

Uzun, Tuğçenur; Toptaş, Orçun; Şaylan, Aslıhan; Carver, Hande; Türkoğlu, Şule Aydın

doi:10.1016/j.joms.2018.12.019

Cited by 13 publications

(14 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reviewing the next follow up period, 7 days, noticeable changes were detected in both periodontal ligament and alveolar bone histology. healing of the periodontal ligament area was nearly established and approached its normal configuration which further supports the results in previous research work 30 . In addition, the ongoing results are in accordance with Kirakozova et al, 2018 who revealed that dexamethasone treatment improved periodontal healing of replanted teeth in dogs.…”

Section: Discussionsupporting

confidence: 91%

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Hakam¹

2020

Egyptian Dental Journal

View full text Add to dashboard Cite

Aim of the study:Dexamethasone is a popular corticosteroid in dental practice. Submucosal infiltration of dexamethasone proved to be effective to relief post-operative symptoms in different clinical and research application. This study was conducted to evaluate the effect of submucosal dexamethasone single injection on the healing of injured periodontal ligament fibers after molar luxation in rats via histological and gene expression studies. Materials and methods:24Wistar rats were selected for the study. Luxation injuries were performed for all first mandibular molars of both mandibular sides, right & left. Immediately after luxation, the right sides of the mandibles received submucosal injections of dexamethasone sodium phosphate (0.4mg/ml), while left sides were not dexamethasone injected. Follow up periods were 1, 3 & 7 days. Mandibular specimens were studied by routine histology, and quantitative gene expression analysis was done for fibroblast growth factor (FGF2), caspase-3 & alkaline phosphatase (ALP). Results:Histological features revealed superior results of the dexamethasone group with better regeneration and organization of fibers. Gene expression results revealed significant increase in the expression of both FGF2 and alkaline phosphatase (ALP) and a significant decrease in the expression of caspase-3 in the study side when compared to the control side.Conclusion: histologically dexamethasone enhanced the regeneration of torn periodontal ligament fibers with noticeable reduction in inflammation and rise in cellular proliferation. Gene expression reflected the possible benefit of dexamethasone single local injection in the management of periodontal ligament injuries.

show abstract

Section: Discussionsupporting

confidence: 91%

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Hakam¹

2020

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

“…In a rabbit model of knee arthrofibrosis, intragastric administration of artesunate significantly decreased the number of fibroblasts and degree of fibrosis in the intraarticular tissue through autophagy driven by inhibition of mechanistic target of rapamycin (mTOR) signaling 94 . In a rat model of compression-induced sciatic nerve injury, application of artesunate to the injury region through a resorbable gelatin sponge resulted in enhanced peripheral nerve regeneration as assessed by improved sciatic nerve function, reduced fibroblast presence and fibrosis, dampened inflammation, and increased myelinated axon diameter, suggesting that artesunate-enhanced nerve regeneration proceeds alongside suppression of inflammatory and fibrotic responses 95 . In a rabbit ear model of hypertrophic scarring, application of cream containing either artemisinin or artesunate led to improved scar appearance, lessened hypertrophy, reduced volume of fibroblasts, and a greater degree of alignment of collagen fibers 96 .…”

Section: Artemisinin and Its Derivatives Alleviate Development Or Promentioning

confidence: 97%

“…The in vivo anti-fibrotic literature described above regarding artemisinin compounds is summarized in Table 1 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 .…”

Section: Artemisinin and Its Derivatives Alleviate Development Or Promentioning

confidence: 99%

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Dolivo

Weathers

Dominko

2021

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis. Artemisinin compounds are best known as antimalarial therapeutics, but they also demonstrate antiparasitic, antibacterial, anticancer, and anti-fibrotic effects. Here we summarize literature describing anti-fibrotic effects of artemisinin compounds in in vivo and in vitro models of tissue fibrosis, and we describe the likely mechanisms by which artemisinin compounds appear to inhibit cellular and tissue processes that lead to fibrosis. To consider alternative routes of administration of artemisinin for treatment of internal organ fibrosis, we also discuss the potential for more direct oral delivery of Artemisia plant material to enhance bioavailability and efficacy of artemisinin compared to administration of purified artemisinin drugs at comparable doses. It is our hope that greater understanding of the broad anti-fibrotic effects of artemisinin drugs will enable and promote their use as therapeutics for treatment of fibrotic diseases.

show abstract

“…It can cross the brain–blood barrier and exert robust neuroprotective and neuroregenerative effects in different CNS diseases such as SCI ( Table 1 ) [1,89–95]. Tacrolimus promotes neuroprotection in addition to neural and axonal regeneration associated with functional recovery in SCI rodents [96–100]. This effect is mediated by inhibiting calcineurin [96–100], increasing neuronal growth‐associated protein (GAP)‐43 levels [91], inhibiting iNOS and superoxide radicals, preventing mitochondrial dysfunction and neuronal apoptosis signaling [101–103], inhibiting caspase 3 activity, and finally attenuating oligodendroglia apoptosis ( Figure ) [104].…”

Section: Antibiotics With Therapeutic Effects In Scimentioning

confidence: 99%

“…Tacrolimus promotes neuroprotection in addition to neural and axonal regeneration associated with functional recovery in SCI rodents [96–100]. This effect is mediated by inhibiting calcineurin [96–100], increasing neuronal growth‐associated protein (GAP)‐43 levels [91], inhibiting iNOS and superoxide radicals, preventing mitochondrial dysfunction and neuronal apoptosis signaling [101–103], inhibiting caspase 3 activity, and finally attenuating oligodendroglia apoptosis ( Figure ) [104]. Other mechanisms underlying such effects of tacrolimus on SCI include attenuating invasion of pro‐inflammatory cells (e.g., macrophages) into the injured sites [105], decreasing glial fibrillary acidic protein (GFAP), COX‐2, and pro‐inflammatory cytokines (e.g., IL‐1β) levels [101], as well as inhibiting nuclear factor kappa B (NF‐kB) activation in microglia [90,93].…”

Section: Antibiotics With Therapeutic Effects In Scimentioning

confidence: 99%

Antibiotics with therapeutic effects on spinal cord injury: a review

Afshari

Roudsari

Lashgari

et al. 2020

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

Accumulating evidence indicates that a considerable number of antibiotics exert anti‐inflammatory and neuroprotective effects in different central and peripheral nervous system diseases including spinal cord injury (SCI). Both clinical and preclinical studies on SCI have found therapeutic effects of antibiotics from different families on SCI. These include macrolides, minocycline, β‐lactams, and dapsone, all of which have been found to improve SCI sequels and complications. These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI‐related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.

show abstract

Evaluation and Comparison of the Effects of Artesunate, Dexamethasone, and Tacrolimus on Sciatic Nerve Regeneration

Cited by 13 publications

References 50 publications

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Antibiotics with therapeutic effects on spinal cord injury: a review

Contact Info

Product

Resources

About